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Protein

Caspase-6

Gene

Casp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity).By similarity

Catalytic activityi

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

Activity regulationi

Activation is suppressed by phosphorylation at Ser-239.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104By similarity1
Active sitei146By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Enzyme and pathway databases

BRENDAi3.4.22.59 3474
ReactomeiR-MMU-111465 Apoptotic cleavage of cellular proteins
R-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-352238 Breakdown of the nuclear lamina

Protein family/group databases

MEROPSiC14.005

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-6 (EC:3.4.22.59)
Short name:
CASP-6
Alternative name(s):
Apoptotic protease Mch-2
Cleaved into the following 2 chains:
Gene namesi
Name:Casp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1312921 Casp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000046121 – 5By similarity5
ChainiPRO_00000046136 – 162Caspase-6 subunit p18By similarityAdd BLAST157
PropeptideiPRO_0000004614163 – 176By similarityAdd BLAST14
ChainiPRO_0000004615177 – 276Caspase-6 subunit p11By similarityAdd BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei239Phosphoserine; by NUAK1By similarity1

Post-translational modificationi

Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.By similarity

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

EPDiO08738
PaxDbiO08738
PeptideAtlasiO08738
PRIDEiO08738

PTM databases

iPTMnetiO08738
PhosphoSitePlusiO08738
SwissPalmiO08738

Expressioni

Tissue specificityi

Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain.

Gene expression databases

BgeeiENSMUSG00000027997 Expressed in 253 organ(s), highest expression level in stomach
CleanExiMM_CASP6
ExpressionAtlasiO08738 baseline and differential
GenevisibleiO08738 MM

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198498, 3 interactors
STRINGi10090.ENSMUSP00000029626

Structurei

3D structure databases

ProteinModelPortaliO08738
SMRiO08738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
HOGENOMiHOG000231878
HOVERGENiHBG050802
InParanoidiO08738
KOiK04396
OMAiVVDHQTD
OrthoDBiEOG091G05YD
PhylomeDBiO08738
TreeFamiTF102023

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR037554 Caspase_6
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454 PTHR10454, 1 hit
PTHR10454:SF164 PTHR10454:SF164, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTETDGFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT
60 70 80 90 100
NADRDNLTRR FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV
110 120 130 140 150
FLSHGEGNHV YAYDAKIEIQ TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ
160 170 180 190 200
HDVPVVPLDM VDHQTDKLDN VTQVDAASVY TLPAGADFLM CYSVAEGYYS
210 220 230 240 250
HRETVNGSWY IQDLCEMLAR YGSSLEFTEL LTLVNRKVSQ RRVDFCKDPD
260 270
AIGKKQVPCF ASMLTKKLHF CPKPSK
Length:276
Mass (Da):31,595
Last modified:July 1, 1997 - v1
Checksum:i5965DE9321126B6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13087 mRNA Translation: CAA73529.1
CCDSiCCDS17838.1
RefSeqiNP_033941.3, NM_009811.4
UniGeneiMm.281379

Genome annotation databases

EnsembliENSMUST00000029626; ENSMUSP00000029626; ENSMUSG00000027997
GeneIDi12368
KEGGimmu:12368
UCSCiuc008riq.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13087 mRNA Translation: CAA73529.1
CCDSiCCDS17838.1
RefSeqiNP_033941.3, NM_009811.4
UniGeneiMm.281379

3D structure databases

ProteinModelPortaliO08738
SMRiO08738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198498, 3 interactors
STRINGi10090.ENSMUSP00000029626

Protein family/group databases

MEROPSiC14.005

PTM databases

iPTMnetiO08738
PhosphoSitePlusiO08738
SwissPalmiO08738

Proteomic databases

EPDiO08738
PaxDbiO08738
PeptideAtlasiO08738
PRIDEiO08738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029626; ENSMUSP00000029626; ENSMUSG00000027997
GeneIDi12368
KEGGimmu:12368
UCSCiuc008riq.3 mouse

Organism-specific databases

CTDi839
MGIiMGI:1312921 Casp6

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00760000118912
HOGENOMiHOG000231878
HOVERGENiHBG050802
InParanoidiO08738
KOiK04396
OMAiVVDHQTD
OrthoDBiEOG091G05YD
PhylomeDBiO08738
TreeFamiTF102023

Enzyme and pathway databases

BRENDAi3.4.22.59 3474
ReactomeiR-MMU-111465 Apoptotic cleavage of cellular proteins
R-MMU-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-MMU-352238 Breakdown of the nuclear lamina

Miscellaneous databases

ChiTaRSiCasp6 mouse
PROiPR:O08738
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027997 Expressed in 253 organ(s), highest expression level in stomach
CleanExiMM_CASP6
ExpressionAtlasiO08738 baseline and differential
GenevisibleiO08738 MM

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR037554 Caspase_6
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR002398 Pept_C14
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454 PTHR10454, 1 hit
PTHR10454:SF164 PTHR10454:SF164, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASP6_MOUSE
AccessioniPrimary (citable) accession number: O08738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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