UniProtKB - O08717 (INHBE_MOUSE)
Protein
Inhibin beta E chain
Gene
Inhbe
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: GO_Central
GO - Biological processi
- cell development Source: GO_Central
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- regulation of apoptotic process Source: GO_Central
- regulation of MAPK cascade Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Growth factor, Hormone |
Enzyme and pathway databases
Reactomei | R-MMU-209822 Glycoprotein hormones |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibin beta E chainAlternative name(s): Activin beta-E chain |
Gene namesi | Name:Inhbe |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109269 Inhbe |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000033738 | 22 – 236 | Sequence analysisAdd BLAST | 215 | |
ChainiPRO_0000033739 | 237 – 350 | Inhibin beta E chainAdd BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 198 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 240 ↔ 248 | By similarity | ||
Disulfide bondi | 247 ↔ 315 | By similarity | ||
Disulfide bondi | 276 ↔ 347 | By similarity | ||
Disulfide bondi | 280 ↔ 349 | By similarity | ||
Disulfide bondi | 314 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MaxQBi | O08717 |
PaxDbi | O08717 |
PRIDEi | O08717 |
PTM databases
iPTMneti | O08717 |
PhosphoSitePlusi | O08717 |
Expressioni
Developmental stagei
First expression in embryonic liver is detected at 17.5 dpc.
Gene expression databases
Bgeei | ENSMUSG00000047492 Expressed in 50 organ(s), highest expression level in epididymal fat pad |
Genevisiblei | O08717 MM |
Interactioni
Subunit structurei
Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053977 |
Structurei
3D structure databases
ProteinModelPortali | O08717 |
SMRi | O08717 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900 Eukaryota ENOG410XT8Z LUCA |
GeneTreei | ENSGT00940000162107 |
HOGENOMi | HOG000220890 |
HOVERGENi | HBG105613 |
InParanoidi | O08717 |
KOi | K22689 |
OMAi | GYQLNYC |
OrthoDBi | 1385831at2759 |
TreeFami | TF318514 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001318 Inhibin_betaC IPR001839 TGF-b_C IPR015615 TGF-beta-rel IPR017948 TGFb_CS |
PANTHERi | PTHR11848 PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019 TGF_beta, 1 hit |
PRINTSi | PR00672 INHIBINBC |
SMARTi | View protein in SMART SM00204 TGFB, 1 hit |
SUPFAMi | SSF57501 SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O08717-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLPKAQLWL ILLWALVWVQ STRSACPSCG GPTLAPQGER ALVLELAKQQ
60 70 80 90 100
ILEGLHLTSR PRITRPLPQA ALTRALRRLQ PKSMVPGNRE KVISFATIID
110 120 130 140 150
KSTSTYRSML TFQLSPLWSH HLYHARLWLH VPPSFPGTLY LRIFRCGTTR
160 170 180 190 200
CRGFRTFLAE HQTTSSGWHA LTLPSSGLRS EDSGVVKLQL EFRPLDLNST
210 220 230 240 250
AAGLPRLLLD TAGQQRPFLE LKIRANEPGA GRARRRTPTC EPETPLCCRR
260 270 280 290 300
DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
310 320 330 340 350
LLKANNPWPA GSSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | T → R in AAB53801 (PubMed:8941337).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U96386 mRNA Translation: AAB53801.1 CH466578 Genomic DNA Translation: EDL24502.1 BC010404 mRNA Translation: AAH10404.1 |
CCDSi | CCDS24239.1 |
PIRi | JC5241 |
RefSeqi | NP_032408.2, NM_008382.3 |
UniGenei | Mm.3510 |
Genome annotation databases
Ensembli | ENSMUST00000059718; ENSMUSP00000053977; ENSMUSG00000047492 |
GeneIDi | 16326 |
KEGGi | mmu:16326 |
UCSCi | uc011xps.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U96386 mRNA Translation: AAB53801.1 CH466578 Genomic DNA Translation: EDL24502.1 BC010404 mRNA Translation: AAH10404.1 |
CCDSi | CCDS24239.1 |
PIRi | JC5241 |
RefSeqi | NP_032408.2, NM_008382.3 |
UniGenei | Mm.3510 |
3D structure databases
ProteinModelPortali | O08717 |
SMRi | O08717 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000053977 |
PTM databases
iPTMneti | O08717 |
PhosphoSitePlusi | O08717 |
Proteomic databases
MaxQBi | O08717 |
PaxDbi | O08717 |
PRIDEi | O08717 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000059718; ENSMUSP00000053977; ENSMUSG00000047492 |
GeneIDi | 16326 |
KEGGi | mmu:16326 |
UCSCi | uc011xps.1 mouse |
Organism-specific databases
CTDi | 83729 |
MGIi | MGI:109269 Inhbe |
Phylogenomic databases
eggNOGi | KOG3900 Eukaryota ENOG410XT8Z LUCA |
GeneTreei | ENSGT00940000162107 |
HOGENOMi | HOG000220890 |
HOVERGENi | HBG105613 |
InParanoidi | O08717 |
KOi | K22689 |
OMAi | GYQLNYC |
OrthoDBi | 1385831at2759 |
TreeFami | TF318514 |
Enzyme and pathway databases
Reactomei | R-MMU-209822 Glycoprotein hormones |
Miscellaneous databases
PROi | PR:O08717 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047492 Expressed in 50 organ(s), highest expression level in epididymal fat pad |
Genevisiblei | O08717 MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034 Cystine-knot_cytokine IPR001318 Inhibin_betaC IPR001839 TGF-b_C IPR015615 TGF-beta-rel IPR017948 TGFb_CS |
PANTHERi | PTHR11848 PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019 TGF_beta, 1 hit |
PRINTSi | PR00672 INHIBINBC |
SMARTi | View protein in SMART SM00204 TGFB, 1 hit |
SUPFAMi | SSF57501 SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | INHBE_MOUSE | |
Accessioni | O08717Primary (citable) accession number: O08717 Secondary accession number(s): Q91XH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 13, 2019 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot