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Protein

Thyroglobulin

Gene

Tg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processThyroid hormones biosynthesis

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
mouse-thyro Thyroglobulin

MEROPS protease database

More...
MEROPSi
I31.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroglobulin
Short name:
Tg
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tg
Synonyms:Tgn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98733 Tg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Tg are the cause of some forms of goiter. Goiter is an enlargement of the thyroid gland. The variant Pro-2283 exhibits a defect in exit from the endoplasmic reticulum.

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000863721 – 2766ThyroglobulinAdd BLAST2746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25Iodotyrosine; alternateBy similarity1
Modified residuei25Sulfotyrosine; alternateBy similarity1
Modified residuei25Thyroxine; alternateBy similarity1
Modified residuei25Triiodothyronine; alternateBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 53PROSITE-ProRule annotation
Disulfide bondi64 ↔ 71PROSITE-ProRule annotation
Disulfide bondi73 ↔ 93PROSITE-ProRule annotation
Disulfide bondi97 ↔ 121PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 139PROSITE-ProRule annotation
Disulfide bondi141 ↔ 161PROSITE-ProRule annotation
Modified residuei150Diiodotyrosine; alternateBy similarity1
Modified residuei150Iodotyrosine; alternateBy similarity1
Disulfide bondi165 ↔ 184PROSITE-ProRule annotation
Disulfide bondi195 ↔ 236PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei259IodotyrosineBy similarity1
Disulfide bondi302 ↔ 320PROSITE-ProRule annotation
Disulfide bondi331 ↔ 337PROSITE-ProRule annotation
Disulfide bondi339 ↔ 359PROSITE-ProRule annotation
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi608 ↔ 620PROSITE-ProRule annotation
Disulfide bondi631 ↔ 636PROSITE-ProRule annotation
Disulfide bondi638 ↔ 658PROSITE-ProRule annotation
Disulfide bondi662 ↔ 687PROSITE-ProRule annotation
Disulfide bondi698 ↔ 703PROSITE-ProRule annotation
Modified residuei704Diiodotyrosine; alternateBy similarity1
Modified residuei704Iodotyrosine; alternateBy similarity1
Modified residuei704Thyroxine; alternateBy similarity1
Modified residuei704Triiodothyronine; alternateBy similarity1
Disulfide bondi705 ↔ 726PROSITE-ProRule annotation
Disulfide bondi730 ↔ 763PROSITE-ProRule annotation
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi774 ↔ 899PROSITE-ProRule annotation
Modified residuei785IodotyrosineBy similarity1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei867Diiodotyrosine; alternateBy similarity1
Modified residuei867Iodotyrosine; alternateBy similarity1
Modified residuei884DiiodotyrosineBy similarity1
Disulfide bondi901 ↔ 922PROSITE-ProRule annotation
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei993Diiodotyrosine; alternateBy similarity1
Modified residuei993Iodotyrosine; alternateBy similarity1
Disulfide bondi1043 ↔ 1050PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1074PROSITE-ProRule annotation
Disulfide bondi1078 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1127 ↔ 1146PROSITE-ProRule annotation
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1150 ↔ 1170PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1189PROSITE-ProRule annotation
Disulfide bondi1191 ↔ 1211PROSITE-ProRule annotation
Modified residuei1310IodotyrosineBy similarity1
Glycosylationi1349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1365N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1513 ↔ 1522PROSITE-ProRule annotation
Disulfide bondi1542 ↔ 1564PROSITE-ProRule annotation
Glycosylationi1715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1773N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1864N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1935N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2120N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2182IodotyrosineBy similarity1
Glycosylationi2249N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2263 ↔ 2280PROSITE-ProRule annotation
Glycosylationi2294N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2572Diiodotyrosine; alternateBy similarity1
Modified residuei2572Iodotyrosine; alternateBy similarity1
Modified residuei2572Thyroxine; alternateBy similarity1
Modified residuei2572Triiodothyronine; alternateBy similarity1
Glycosylationi2581N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2586IodotyrosineBy similarity1
Modified residuei2616IodotyrosineBy similarity1
Modified residuei2696DiiodotyrosineBy similarity1
Modified residuei2764Diiodotyrosine; alternateBy similarity1
Modified residuei2764Iodotyrosine; alternateBy similarity1
Modified residuei2764Thyroxine; alternateBy similarity1
Modified residuei2764Triiodothyronine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated tyrosines are desulfated during iodination.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Iodination, Sulfation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O08710

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O08710

PRoteomics IDEntifications database

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PRIDEi
O08710

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08710

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O08710

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Thyroid gland specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053469 Expressed in 41 organ(s), highest expression level in thyroid gland

CleanEx database of gene expression profiles

More...
CleanExi
MM_TG

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O08710 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O08710 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000070239

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 93Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini94 – 161Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini162 – 298Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST137
Domaini299 – 359Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini605 – 658Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini659 – 726Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST68
Domaini727 – 922Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST196
Domaini923 – 1074Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST152
Domaini1075 – 1146Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST72
Domaini1147 – 1211Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST65
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1455 – 1468Type IIAdd BLAST14
Repeati1469 – 1485Type IIAdd BLAST17
Repeati1486 – 1502Type IIAdd BLAST17
Domaini1510 – 1564Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST55
Repeati1602 – 1722Type IIIAAdd BLAST121
Repeati1723 – 1889Type IIIBAdd BLAST167
Repeati1890 – 1992Type IIIAAdd BLAST103
Repeati1993 – 2125Type IIIBAdd BLAST133
Repeati2126 – 2183Type IIIAAdd BLAST58

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG6K Eukaryota
COG2272 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159300

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000128427

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG017929

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O08710

KEGG Orthology (KO)

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KOi
K10809

Identification of Orthologs from Complete Genome Data

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OMAi
LRSCWCV

Database of Orthologous Groups

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OrthoDBi
754103at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351833

Family and domain databases

Conserved Domains Database

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CDDi
cd00191 TY, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1820, 1 hit
4.10.800.10, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 11 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001831 Thyroglobulin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit
SSF57610 SSF57610, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08710-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTALVLWVST LLSSVCLVAA NIFEYQVDAQ PLRPCELQRE KAFLKQAEYV
60 70 80 90 100
PQCSEDGSFQ TVQCQNDGQS CWCVDSDGRE VPGSRQLGRP TVCLSFCQLH
110 120 130 140 150
KQRILLGSYI NSTDALYLPQ CQDSGNYAPV QCDLQRVQCW CVDTEGMEVY
160 170 180 190 200
GTRQQGRPTR CPRSCEIRNR RLLHGVGDRS PPQCTADGEF MPVQCKFVNT
210 220 230 240 250
TDMMIFDLIH NYNRFPDAFV TFSSFRGRFP EVSGYCYCAD SQGRELAETG
260 270 280 290 300
LELLLDEIYD TIFAGLDQAS TFTQSTMYRI LQRRFLAIQL VISGRFRCPT
310 320 330 340 350
KCEVEQFAAT RFGHSYIPRC HRDGHYQTVQ CQTEGMCWCV DAQGREVPGT
360 370 380 390 400
RQQGQPPSCA ADQSCALERQ QALSRFYFET PDYFSPQDLL SSEDRLAPVS
410 420 430 440 450
GVRSDTSCPP RIKELFVDSG LLRSIAVEHY QRLSESRSLL REAIRAVFPS
460 470 480 490 500
RELAGLALQF TTNPKRLQQN LFGGTFLANA AQFNLSGALG TRSTFNFSQF
510 520 530 540 550
FQQFGLPGFL NRDRVTTLAK LLPVRLDSSS TPETLRVSEK TVAMNKRVVG
560 570 580 590 600
NFGFKVNLQE NQDALKFLVS LLELPEFLVF LQRAVSVPED IARDLGDVME
610 620 630 640 650
MVFSAQACKQ MPGKFFVPSC TAGGSYEDIQ CYAGECWCVD SRGKELDGSR
660 670 680 690 700
VRGGRPRCPT KCEKQRAQMQ SLASAQPAGS SFFVPTCTRE GYFLPVQCFN
710 720 730 740 750
SECYCVDTEG QVIPGTQSTV GEAKQCPSVC QLQAEQAFLG VVGVLLSNSS
760 770 780 790 800
MVPSISNVYI PQCSASGQWR HVQCDGPHEQ VFEWYERWKT QNGDGQELTP
810 820 830 840 850
AALLMKIVSY REVASRNFSL FLQSLYDAGQ QRIFPVLAQY PSLQDVPQVV
860 870 880 890 900
LEGATTPPGE NIFLDPYIFW QILNGQLSQY PGPYSDFNMP LEHFNLRSCW
910 920 930 940 950
CVDEAGQKLD GTQTKPGEIP ACPGPCEEVK LRVLKFIKET EEIVSASNAS
960 970 980 990 1000
SFPLGESFLV AKGIQLTSEE LDLPPQFPSR DAFSEKFLRG GEYAIRLAAQ
1010 1020 1030 1040 1050
STLTFYQSLR ASLGKSDGAA SLLWSGPYMP QCNMIGGWEP VQCHAGTGQC
1060 1070 1080 1090 1100
WCVDGRGEFI PGSLMSRSSQ MPQCPTNCEL SRASGLISAW KQAGPQRNPG
1110 1120 1130 1140 1150
PGDLFIPVCL QTGEYVRKQT SGTGTWCVDP ASGEGMPVNT NGSAQCPGLC
1160 1170 1180 1190 1200
DVLKSRALSR KVGLGYSPVC EALDGAFSPV QCDLAQGSCW CVLGSGEEVP
1210 1220 1230 1240 1250
GTRVVGTQPA CESPQCPLPF SGSDVADGVI FCETASSSGV TTVQQCQLLC
1260 1270 1280 1290 1300
RQGLRSAFSP GPLICSLESQ HWVTLPPPRA CQRPQLWQTM QTQAHFQLLL
1310 1320 1330 1340 1350
PPGKMCSVDY SGLLQAFQVF ILDELIARGF CQIQVKTFGT LVSSTVCDNS
1360 1370 1380 1390 1400
SIQVGCLTAE RLGVNVTWKL QLEDISVGSL PDLYSIERAV TGQDLLGRFA
1410 1420 1430 1440 1450
DLIQSGRFQL HLDSKTFSAD TTLYFLNGDS FVTSPRTQLG CMEGFYRVPT
1460 1470 1480 1490 1500
TRQDALGCVK CPEGSFSQDG RCTPCPAGTY QEQAGSSACI PCPRGRTTIT
1510 1520 1530 1540 1550
TGAFSKTHCV TDCQKNEAGL QCDQNGQYQA SQKNRDSGEV FCVDSEGRKL
1560 1570 1580 1590 1600
QWLQTEAGLS ESQCLMIRKF DKAPESKVIF DANSPVIVKS SVPSADSPLV
1610 1620 1630 1640 1650
QCLTDCANDE ACSFLTVSTM ESEVSCDFYS WTRDNFACVT SDQEQDAMGS
1660 1670 1680 1690 1700
LKATSFGSLR CQVKVRNSGK DSLAVYVKKG YESTAAGQKS FEPTGFQNVL
1710 1720 1730 1740 1750
SGLYSPVVFS ASGANLTDTH TYCLLACDND SCCDGFIITQ VKGGPTICGL
1760 1770 1780 1790 1800
LSSPDILLCH INDWRDTSAT QANATCAGVT YDQGSRQMTL SLGGQEFLQG
1810 1820 1830 1840 1850
LALLEGTQDS FTSFQQVYLW KDSDMGSRPE SMGCERGMVP RSDFPGDMAT
1860 1870 1880 1890 1900
ELFSPVDITQ VIVNTSHSLP SQQYWLFTHL FSAEQANLWC LSRCAQEPIF
1910 1920 1930 1940 1950
CQLADITKSS SLYFTCFLYP EAQVCDNVME SNAKNCSQIL PHQPTALFRR
1960 1970 1980 1990 2000
KVVLNDRVKN FYTRLPFQKL TGISIRDKVP MSGKLISNGF FECERLCDRD
2010 2020 2030 2040 2050
PCCTGFGFLN VSQLQGGEVT CLTLNSMGIQ TCNEESGATW RILDCGSEDT
2060 2070 2080 2090 2100
EVHTYPFGWY QKPAVWSDTP SFCPSAALQS LTEEKVTSDS WQTLALSSVI
2110 2120 2130 2140 2150
VDPSIKHFDV AHISTAATSN FSMAQDFCLQ QCSRHQDCLV TTLQIQPGVV
2160 2170 2180 2190 2200
RCVFYPDIQN CIHSLRSHTC WLLLHEEATY IYRKSGIPLV QSDVTSTPSV
2210 2220 2230 2240 2250
RIDSFGQLQG GSQVIKVGTA WKQVYRFLGV PYAAPPLADN RFRAPEVLNW
2260 2270 2280 2290 2300
TGSWDATKPR ASCWQPGTRT PTPPQINEDC LYLNVFVPEN LVSNASVLVF
2310 2320 2330 2340 2350
FHNTMEMEGS GGQLTIDGSI LAAVGNFIVV TANYRLGVFG FLSSGSDEVA
2360 2370 2380 2390 2400
GNWGLLDQVA ALTWVQSHIG AFGGDPQRVT LAADRSGADV ASIHLLISRP
2410 2420 2430 2440 2450
TRLQLFRKAL LMGGSALSPA AIISPERAQQ QAAALAKEVG CPTSSIQEVV
2460 2470 2480 2490 2500
SCLRQKPANI LNDAQTKLLA VSGPFHYWGP VVDGQYLREL PSRRLKRPLP
2510 2520 2530 2540 2550
VKVDLLIGGS QDDGLINRAK AVKQFEESQG RTNSKTAFYQ ALQNSLGGED
2560 2570 2580 2590 2600
SDARILAAAV WYYSLEHSTD DYASFSRALE NATRDYFIIC PMVNMASLWA
2610 2620 2630 2640 2650
RRTRGNVFMY HVPESYGHGS LELLADVQYA FGLPFYSAYQ GQFSTEEQSL
2660 2670 2680 2690 2700
SLKVMQYFSN FIRSGNPNYP HEFSRKAAEF ATPWPDFIPG AGGESYKELS
2710 2720 2730 2740 2750
AQLPNRQGLK QADCSFWSKY IQTLKDADGA KDAQLTKSEE EDLEVGPGLE
2760
EDLSGSLEPV PKSYSK
Length:2,766
Mass (Da):304,473
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06227D4192AC1902
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6P7M8A6P7M8_MOUSE
Kidney thyroglobulin variant
Tg kTg
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XYF6F6XYF6_MOUSE
Thyroglobulin
Tg
1,147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80E → K in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti80E → K in AAC32269 (Ref. 3) Curated1
Sequence conflicti92V → I in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti92V → I in AAC32269 (Ref. 3) Curated1
Sequence conflicti1327A → T in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1427N → S in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1436 – 1442RTQLGCM → GLSLDVL in AAB53204 (PubMed:9344706).Curated7
Sequence conflicti1721T → I in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1813S → T in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1957 – 1959RVK → KVN in AAC32268 (PubMed:9707574).Curated3
Sequence conflicti1957 – 1959RVK → KVN in AAC32269 (Ref. 3) Curated3
Sequence conflicti2090S → SS in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti2407R → K in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2407R → K in AAC32269 (Ref. 3) Curated1
Sequence conflicti2414G → S in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2414G → S in AAC32269 (Ref. 3) Curated1
Sequence conflicti2427R → K in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2427R → K in AAC32269 (Ref. 3) Curated1
Sequence conflicti2434A → T in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2434A → T in AAC32269 (Ref. 3) Curated1
Sequence conflicti2443 – 2453TSSIQEVVSCL → NFIHPGSGIMF in AAC32268 (PubMed:9707574).CuratedAdd BLAST11
Sequence conflicti2443 – 2453TSSIQEVVSCL → NFIHPGSGIMF in AAC32269 (Ref. 3) CuratedAdd BLAST11
Sequence conflicti2728D → GN in AAB53204 (PubMed:9344706).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2283L → P in goiter. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U76389 mRNA Translation: AAB53204.1
AF076186 mRNA Translation: AAC32268.1
AF076187 mRNA Translation: AAC32269.1
CH466545 Genomic DNA Translation: EDL29374.1
BC111467 mRNA Translation: AAI11468.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37091.1

NCBI Reference Sequences

More...
RefSeqi
NP_033401.2, NM_009375.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.441333

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000065916; ENSMUSP00000070239; ENSMUSG00000053469

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
21819

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21819

UCSC genome browser

More...
UCSCi
uc007wap.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76389 mRNA Translation: AAB53204.1
AF076186 mRNA Translation: AAC32268.1
AF076187 mRNA Translation: AAC32269.1
CH466545 Genomic DNA Translation: EDL29374.1
BC111467 mRNA Translation: AAI11468.1
CCDSiCCDS37091.1
RefSeqiNP_033401.2, NM_009375.2
UniGeneiMm.441333

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070239

Protein family/group databases

ESTHERimouse-thyro Thyroglobulin
MEROPSiI31.950

PTM databases

iPTMnetiO08710
PhosphoSitePlusiO08710

Proteomic databases

MaxQBiO08710
PaxDbiO08710
PRIDEiO08710

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065916; ENSMUSP00000070239; ENSMUSG00000053469
GeneIDi21819
KEGGimmu:21819
UCSCiuc007wap.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7038
MGIiMGI:98733 Tg

Phylogenomic databases

eggNOGiENOG410IG6K Eukaryota
COG2272 LUCA
GeneTreeiENSGT00940000159300
HOGENOMiHOG000128427
HOVERGENiHBG017929
InParanoidiO08710
KOiK10809
OMAiLRSCWCV
OrthoDBi754103at2759
TreeFamiTF351833

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tg mouse

Protein Ontology

More...
PROi
PR:O08710

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053469 Expressed in 41 organ(s), highest expression level in thyroid gland
CleanExiMM_TG
ExpressionAtlasiO08710 baseline and differential
GenevisibleiO08710 MM

Family and domain databases

CDDicd00191 TY, 7 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 7 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 11 hits
PIRSFiPIRSF001831 Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits
SUPFAMiSSF53474 SSF53474, 1 hit
SSF57610 SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHYG_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08710
Secondary accession number(s): O88590, Q2NKY1, Q9QWY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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