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UniProtKB - O08710 (THYG_MOUSE)

Entry version 172 (07 Oct 2020)
Sequence version 3 (27 Jul 2011)
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Protein

Thyroglobulin

Gene

Tg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). One dimer produces 7 thyroid hormone molecules (By similarity).By similarity1 Publication

Caution

The cholinesterase-like (ChEL) region lacks the Ser residue of the catalytic triad suggesting that it has no esterase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processThyroid hormones biosynthesis

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		mouse-thyro, Thyroglobulin

MEROPS protease database

More...MEROPSi		I31.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroglobulin
Short name:
Tg
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tg
Synonyms:Tgn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:98733, Tg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital goiter (cog) is caused by a hypertrophy of the thyroid gland (goiter). Mice have reduced growth rate, hypothyroidism due to reduced production of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), and lack colloid globules, a structure in the thyroid follicle lumen that is enriched in Tg/thyroglobulin.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2318G → R: Impairs secretion. 1 Publication1

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000863721 – 2766ThyroglobulinAdd BLAST2746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25Iodotyrosine; alternateBy similarity1
Modified residuei25Sulfotyrosine; alternateBy similarity1
Modified residuei25Thyroxine; alternateBy similarity1
Modified residuei25Triiodothyronine; alternateBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 53PROSITE-ProRule annotation
Disulfide bondi64 ↔ 71PROSITE-ProRule annotation
Disulfide bondi73 ↔ 93PROSITE-ProRule annotation
Disulfide bondi97 ↔ 121PROSITE-ProRule annotation
Modified residuei109IodotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 139PROSITE-ProRule annotation
Disulfide bondi141 ↔ 161PROSITE-ProRule annotation
Modified residuei150Diiodotyrosine; alternateBy similarity1
Modified residuei150Iodotyrosine; alternateBy similarity1
Disulfide bondi165 ↔ 184PROSITE-ProRule annotation
Disulfide bondi195 ↔ 236PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei235IodotyrosineBy similarity1
Modified residuei259IodotyrosineBy similarity1
Disulfide bondi302 ↔ 320PROSITE-ProRule annotation
Disulfide bondi331 ↔ 337PROSITE-ProRule annotation
Disulfide bondi339 ↔ 359PROSITE-ProRule annotation
Disulfide bondi365 ↔ 620By similarity
Disulfide bondi408 ↔ 608By similarity
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi631 ↔ 636PROSITE-ProRule annotation
Disulfide bondi638 ↔ 658PROSITE-ProRule annotation
Disulfide bondi662 ↔ 687PROSITE-ProRule annotation
Disulfide bondi698 ↔ 703PROSITE-ProRule annotation
Modified residuei704Diiodotyrosine; alternateBy similarity1
Modified residuei704Iodotyrosine; alternateBy similarity1
Modified residuei704Thyroxine; alternateBy similarity1
Modified residuei704Triiodothyronine; alternateBy similarity1
Disulfide bondi705 ↔ 726PROSITE-ProRule annotation
Disulfide bondi730 ↔ 763PROSITE-ProRule annotation
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi774 ↔ 899PROSITE-ProRule annotation
Modified residuei785IodotyrosineBy similarity1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei867Diiodotyrosine; alternateBy similarity1
Modified residuei867Iodotyrosine; alternateBy similarity1
Modified residuei884DiiodotyrosineBy similarity1
Disulfide bondi901 ↔ 922PROSITE-ProRule annotation
Disulfide bondi926 ↔ 1032By similarity
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei993Diiodotyrosine; alternateBy similarity1
Modified residuei993Iodotyrosine; alternateBy similarity1
Disulfide bondi1043 ↔ 1050PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1074PROSITE-ProRule annotation
Disulfide bondi1078 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1127 ↔ 1146PROSITE-ProRule annotation
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1150 ↔ 1170PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1189PROSITE-ProRule annotation
Disulfide bondi1191 ↔ 1211PROSITE-ProRule annotation
Disulfide bondi1216 ↔ 1265By similarity
Disulfide bondi1232 ↔ 1246By similarity
Disulfide bondi1306 ↔ 1356By similarity
Modified residuei1310IodotyrosineBy similarity1
Modified residuei1310ThyroxineBy similarity1
Disulfide bondi1331 ↔ 1347By similarity
Glycosylationi1349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1365N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1441 ↔ 1458By similarity
Disulfide bondi1461 ↔ 1472By similarity
Disulfide bondi1475 ↔ 1489By similarity
Disulfide bondi1492 ↔ 1509By similarity
Disulfide bondi1513 ↔ 1522PROSITE-ProRule annotation
Disulfide bondi1542 ↔ 1564PROSITE-ProRule annotation
Disulfide bondi1602 ↔ 1626By similarity
Disulfide bondi1606 ↔ 1612By similarity
Disulfide bondi1638 ↔ 1661By similarity
Glycosylationi1715N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1723 ↔ 1748By similarity
Disulfide bondi1727 ↔ 1733By similarity
Glycosylationi1729N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1732 ↔ 1834By similarity
Disulfide bondi1759 ↔ 1776By similarity
Glycosylationi1773N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1864N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1890 ↔ 1916By similarity
Disulfide bondi1894 ↔ 1901By similarity
Disulfide bondi1925 ↔ 1936By similarity
Glycosylationi1935N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1993 ↔ 2021By similarity
Disulfide bondi1997 ↔ 2003By similarity
Disulfide bondi2002 ↔ 2073By similarity
Glycosylationi2010N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2032 ↔ 2045By similarity
Glycosylationi2120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2128 ↔ 2152By similarity
Disulfide bondi2132 ↔ 2138By similarity
Disulfide bondi2161 ↔ 2170By similarity
Modified residuei2182IodotyrosineBy similarity1
Glycosylationi2249N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2263 ↔ 2280PROSITE-ProRule annotation
Glycosylationi2294N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2441 ↔ 2452By similarity
Modified residuei2539ThyroxineBy similarity1
Modified residuei2572Diiodotyrosine; alternateBy similarity1
Modified residuei2572Iodotyrosine; alternateBy similarity1
Modified residuei2572Thyroxine; alternateBy similarity1
Modified residuei2572Triiodothyronine; alternateBy similarity1
Glycosylationi2581N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2586IodotyrosineBy similarity1
Disulfide bondi2590 ↔ 2714By similarity
Modified residuei2616IodotyrosineBy similarity1
Modified residuei2696DiiodotyrosineBy similarity1
Modified residuei2764Diiodotyrosine; alternateBy similarity1
Modified residuei2764Iodotyrosine; alternateBy similarity1
Modified residuei2764Thyroxine; alternateBy similarity1
Modified residuei2764Triiodothyronine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Iodinated on tyrosine residues by TPO (By similarity). There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-25 is coupled to donor Tyr-150 or Tyr-235, acceptor Tyr-2572 is coupled to donor Tyr-2539, acceptor Tyr-2764 in monomer 1 is coupled to donor Tyr-2764 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-109 in monomer 2 (By similarity).By similarity
Sulfated tyrosines are desulfated during iodination.By similarity
Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones (PubMed:12782676). In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL (PubMed:12782676). Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4 (PubMed:12782676). Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones (Probable).1 Publication1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Iodination, Sulfation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3953

Encyclopedia of Proteome Dynamics

More...EPDi		O08710

MaxQB - The MaxQuant DataBase

More...MaxQBi		O08710

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O08710

PRoteomics IDEntifications database

More...PRIDEi		O08710

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O08710, 20 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O08710

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O08710

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in the thyroid gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000053469, Expressed in thyroid gland and 71 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O08710, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O08710, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:12782676). Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus (PubMed:19276074, PubMed:12782676). Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen (By similarity).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		204170, 3 interactors

Protein interaction database and analysis system

More...IntActi		O08710, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000070239

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O08710, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O08710

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 93Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini94 – 161Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini162 – 298Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST137
Domaini299 – 359Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini605 – 658Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini659 – 726Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST68
Domaini727 – 922Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST196
Domaini923 – 1074Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST152
Domaini1075 – 1146Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST72
Domaini1147 – 1211Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST65
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1455 – 1468Type IIBy similarityAdd BLAST14
Repeati1469 – 1485Type IIBy similarityAdd BLAST17
Repeati1486 – 1502Type IIBy similarityAdd BLAST17
Domaini1510 – 1564Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST55
Repeati1602 – 1722Type IIIABy similarityAdd BLAST121
Repeati1723 – 1889Type IIIBBy similarityAdd BLAST167
Repeati1890 – 1992Type IIIABy similarityAdd BLAST103
Repeati1993 – 2125Type IIIBBy similarityAdd BLAST133
Repeati2126 – 2183Type IIIABy similarityAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2186 – 2766Cholinesterase-like (ChEL)1 PublicationAdd BLAST581

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cholinesterase-like (ChEL) region is required for dimerization and export from the endoplasmic reticulum.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1214, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159300

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000943_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O08710

KEGG Orthology (KO)

More...KOi		K10809

Identification of Orthologs from Complete Genome Data

More...OMAi		DEQCIPC

Database of Orthologous Groups

More...OrthoDBi		754103at2759

TreeFam database of animal gene trees

More...TreeFami		TF351833

Family and domain databases

Conserved Domains Database

More...CDDi		cd00191, TY, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit
4.10.800.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR016324, Thyroglobulin
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00135, COesterase, 1 hit
PF07699, Ephrin_rec_like, 1 hit
PF00086, Thyroglobulin_1, 10 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001831, Thyroglobulin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01411, Ephrin_rec_like, 1 hit
SM00211, TY, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit
SSF57610, SSF57610, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 9 hits
PS51162, THYROGLOBULIN_1_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08710-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTALVLWVST LLSSVCLVAA NIFEYQVDAQ PLRPCELQRE KAFLKQAEYV 
        60         70         80         90        100
PQCSEDGSFQ TVQCQNDGQS CWCVDSDGRE VPGSRQLGRP TVCLSFCQLH 
       110        120        130        140        150
KQRILLGSYI NSTDALYLPQ CQDSGNYAPV QCDLQRVQCW CVDTEGMEVY 
       160        170        180        190        200
GTRQQGRPTR CPRSCEIRNR RLLHGVGDRS PPQCTADGEF MPVQCKFVNT 
       210        220        230        240        250
TDMMIFDLIH NYNRFPDAFV TFSSFRGRFP EVSGYCYCAD SQGRELAETG 
       260        270        280        290        300
LELLLDEIYD TIFAGLDQAS TFTQSTMYRI LQRRFLAIQL VISGRFRCPT 
       310        320        330        340        350
KCEVEQFAAT RFGHSYIPRC HRDGHYQTVQ CQTEGMCWCV DAQGREVPGT 
       360        370        380        390        400
RQQGQPPSCA ADQSCALERQ QALSRFYFET PDYFSPQDLL SSEDRLAPVS 
       410        420        430        440        450
GVRSDTSCPP RIKELFVDSG LLRSIAVEHY QRLSESRSLL REAIRAVFPS 
       460        470        480        490        500
RELAGLALQF TTNPKRLQQN LFGGTFLANA AQFNLSGALG TRSTFNFSQF 
       510        520        530        540        550
FQQFGLPGFL NRDRVTTLAK LLPVRLDSSS TPETLRVSEK TVAMNKRVVG 
       560        570        580        590        600
NFGFKVNLQE NQDALKFLVS LLELPEFLVF LQRAVSVPED IARDLGDVME 
       610        620        630        640        650
MVFSAQACKQ MPGKFFVPSC TAGGSYEDIQ CYAGECWCVD SRGKELDGSR 
       660        670        680        690        700
VRGGRPRCPT KCEKQRAQMQ SLASAQPAGS SFFVPTCTRE GYFLPVQCFN 
       710        720        730        740        750
SECYCVDTEG QVIPGTQSTV GEAKQCPSVC QLQAEQAFLG VVGVLLSNSS 
       760        770        780        790        800
MVPSISNVYI PQCSASGQWR HVQCDGPHEQ VFEWYERWKT QNGDGQELTP 
       810        820        830        840        850
AALLMKIVSY REVASRNFSL FLQSLYDAGQ QRIFPVLAQY PSLQDVPQVV 
       860        870        880        890        900
LEGATTPPGE NIFLDPYIFW QILNGQLSQY PGPYSDFNMP LEHFNLRSCW 
       910        920        930        940        950
CVDEAGQKLD GTQTKPGEIP ACPGPCEEVK LRVLKFIKET EEIVSASNAS 
       960        970        980        990       1000
SFPLGESFLV AKGIQLTSEE LDLPPQFPSR DAFSEKFLRG GEYAIRLAAQ 
      1010       1020       1030       1040       1050
STLTFYQSLR ASLGKSDGAA SLLWSGPYMP QCNMIGGWEP VQCHAGTGQC 
      1060       1070       1080       1090       1100
WCVDGRGEFI PGSLMSRSSQ MPQCPTNCEL SRASGLISAW KQAGPQRNPG 
      1110       1120       1130       1140       1150
PGDLFIPVCL QTGEYVRKQT SGTGTWCVDP ASGEGMPVNT NGSAQCPGLC 
      1160       1170       1180       1190       1200
DVLKSRALSR KVGLGYSPVC EALDGAFSPV QCDLAQGSCW CVLGSGEEVP 
      1210       1220       1230       1240       1250
GTRVVGTQPA CESPQCPLPF SGSDVADGVI FCETASSSGV TTVQQCQLLC 
      1260       1270       1280       1290       1300
RQGLRSAFSP GPLICSLESQ HWVTLPPPRA CQRPQLWQTM QTQAHFQLLL 
      1310       1320       1330       1340       1350
PPGKMCSVDY SGLLQAFQVF ILDELIARGF CQIQVKTFGT LVSSTVCDNS 
      1360       1370       1380       1390       1400
SIQVGCLTAE RLGVNVTWKL QLEDISVGSL PDLYSIERAV TGQDLLGRFA 
      1410       1420       1430       1440       1450
DLIQSGRFQL HLDSKTFSAD TTLYFLNGDS FVTSPRTQLG CMEGFYRVPT 
      1460       1470       1480       1490       1500
TRQDALGCVK CPEGSFSQDG RCTPCPAGTY QEQAGSSACI PCPRGRTTIT 
      1510       1520       1530       1540       1550
TGAFSKTHCV TDCQKNEAGL QCDQNGQYQA SQKNRDSGEV FCVDSEGRKL 
      1560       1570       1580       1590       1600
QWLQTEAGLS ESQCLMIRKF DKAPESKVIF DANSPVIVKS SVPSADSPLV 
      1610       1620       1630       1640       1650
QCLTDCANDE ACSFLTVSTM ESEVSCDFYS WTRDNFACVT SDQEQDAMGS 
      1660       1670       1680       1690       1700
LKATSFGSLR CQVKVRNSGK DSLAVYVKKG YESTAAGQKS FEPTGFQNVL 
      1710       1720       1730       1740       1750
SGLYSPVVFS ASGANLTDTH TYCLLACDND SCCDGFIITQ VKGGPTICGL 
      1760       1770       1780       1790       1800
LSSPDILLCH INDWRDTSAT QANATCAGVT YDQGSRQMTL SLGGQEFLQG 
      1810       1820       1830       1840       1850
LALLEGTQDS FTSFQQVYLW KDSDMGSRPE SMGCERGMVP RSDFPGDMAT 
      1860       1870       1880       1890       1900
ELFSPVDITQ VIVNTSHSLP SQQYWLFTHL FSAEQANLWC LSRCAQEPIF 
      1910       1920       1930       1940       1950
CQLADITKSS SLYFTCFLYP EAQVCDNVME SNAKNCSQIL PHQPTALFRR 
      1960       1970       1980       1990       2000
KVVLNDRVKN FYTRLPFQKL TGISIRDKVP MSGKLISNGF FECERLCDRD 
      2010       2020       2030       2040       2050
PCCTGFGFLN VSQLQGGEVT CLTLNSMGIQ TCNEESGATW RILDCGSEDT 
      2060       2070       2080       2090       2100
EVHTYPFGWY QKPAVWSDTP SFCPSAALQS LTEEKVTSDS WQTLALSSVI 
      2110       2120       2130       2140       2150
VDPSIKHFDV AHISTAATSN FSMAQDFCLQ QCSRHQDCLV TTLQIQPGVV 
      2160       2170       2180       2190       2200
RCVFYPDIQN CIHSLRSHTC WLLLHEEATY IYRKSGIPLV QSDVTSTPSV 
      2210       2220       2230       2240       2250
RIDSFGQLQG GSQVIKVGTA WKQVYRFLGV PYAAPPLADN RFRAPEVLNW 
      2260       2270       2280       2290       2300
TGSWDATKPR ASCWQPGTRT PTPPQINEDC LYLNVFVPEN LVSNASVLVF 
      2310       2320       2330       2340       2350
FHNTMEMEGS GGQLTIDGSI LAAVGNFIVV TANYRLGVFG FLSSGSDEVA 
      2360       2370       2380       2390       2400
GNWGLLDQVA ALTWVQSHIG AFGGDPQRVT LAADRSGADV ASIHLLISRP 
      2410       2420       2430       2440       2450
TRLQLFRKAL LMGGSALSPA AIISPERAQQ QAAALAKEVG CPTSSIQEVV 
      2460       2470       2480       2490       2500
SCLRQKPANI LNDAQTKLLA VSGPFHYWGP VVDGQYLREL PSRRLKRPLP 
      2510       2520       2530       2540       2550
VKVDLLIGGS QDDGLINRAK AVKQFEESQG RTNSKTAFYQ ALQNSLGGED 
      2560       2570       2580       2590       2600
SDARILAAAV WYYSLEHSTD DYASFSRALE NATRDYFIIC PMVNMASLWA 
      2610       2620       2630       2640       2650
RRTRGNVFMY HVPESYGHGS LELLADVQYA FGLPFYSAYQ GQFSTEEQSL 
      2660       2670       2680       2690       2700
SLKVMQYFSN FIRSGNPNYP HEFSRKAAEF ATPWPDFIPG AGGESYKELS 
      2710       2720       2730       2740       2750
AQLPNRQGLK QADCSFWSKY IQTLKDADGA KDAQLTKSEE EDLEVGPGLE 
      2760 
EDLSGSLEPV PKSYSK
Length:2,766
Mass (Da):304,473
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06227D4192AC1902
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6P7M8A6P7M8_MOUSE
Kidney thyroglobulin variant
Tg kTg
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XYF6F6XYF6_MOUSE
Thyroglobulin
Tg
1,147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80E → K in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti80E → K in AAC32269 (Ref. 3) Curated1
Sequence conflicti92V → I in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti92V → I in AAC32269 (Ref. 3) Curated1
Sequence conflicti1327A → T in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1427N → S in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1436 – 1442RTQLGCM → GLSLDVL in AAB53204 (PubMed:9344706).Curated7
Sequence conflicti1721T → I in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1813S → T in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti1957 – 1959RVK → KVN in AAC32268 (PubMed:9707574).Curated3
Sequence conflicti1957 – 1959RVK → KVN in AAC32269 (Ref. 3) Curated3
Sequence conflicti2090S → SS in AAB53204 (PubMed:9344706).Curated1
Sequence conflicti2407R → K in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2407R → K in AAC32269 (Ref. 3) Curated1
Sequence conflicti2414G → S in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2414G → S in AAC32269 (Ref. 3) Curated1
Sequence conflicti2427R → K in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2427R → K in AAC32269 (Ref. 3) Curated1
Sequence conflicti2434A → T in AAC32268 (PubMed:9707574).Curated1
Sequence conflicti2434A → T in AAC32269 (Ref. 3) Curated1
Sequence conflicti2443 – 2453TSSIQEVVSCL → NFIHPGSGIMF in AAC32268 (PubMed:9707574).CuratedAdd BLAST11
Sequence conflicti2443 – 2453TSSIQEVVSCL → NFIHPGSGIMF in AAC32269 (Ref. 3) CuratedAdd BLAST11
Sequence conflicti2728D → GN in AAB53204 (PubMed:9344706).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2283L → P in cog; impairs secretion due to ER retention. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U76389 mRNA Translation: AAB53204.1
AF076186 mRNA Translation: AAC32268.1
AF076187 mRNA Translation: AAC32269.1
CH466545 Genomic DNA Translation: EDL29374.1
BC111467 mRNA Translation: AAI11468.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37091.1

NCBI Reference Sequences

More...RefSeqi		NP_033401.2, NM_009375.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000065916; ENSMUSP00000070239; ENSMUSG00000053469

Database of genes from NCBI RefSeq genomes

More...GeneIDi		21819

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:21819

UCSC genome browser

More...UCSCi		uc007wap.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76389 mRNA Translation: AAB53204.1
AF076186 mRNA Translation: AAC32268.1
AF076187 mRNA Translation: AAC32269.1
CH466545 Genomic DNA Translation: EDL29374.1
BC111467 mRNA Translation: AAI11468.1
CCDSiCCDS37091.1
RefSeqiNP_033401.2, NM_009375.2

3D structure databases

SMRiO08710
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204170, 3 interactors
IntActiO08710, 1 interactor
STRINGi10090.ENSMUSP00000070239

Protein family/group databases

ESTHERimouse-thyro, Thyroglobulin
MEROPSiI31.950

PTM databases

GlyGeniO08710, 20 sites
iPTMnetiO08710
PhosphoSitePlusiO08710

Proteomic databases

CPTACinon-CPTAC-3953
EPDiO08710
MaxQBiO08710
PaxDbiO08710
PRIDEiO08710

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O08710, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		860, 1762 antibodies

Genome annotation databases

EnsembliENSMUST00000065916; ENSMUSP00000070239; ENSMUSG00000053469
GeneIDi21819
KEGGimmu:21819
UCSCiuc007wap.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7038
MGIiMGI:98733, Tg

Phylogenomic databases

eggNOGiKOG1214, Eukaryota
GeneTreeiENSGT00940000159300
HOGENOMiCLU_000943_0_0_1
InParanoidiO08710
KOiK10809
OMAiDEQCIPC
OrthoDBi754103at2759
TreeFamiTF351833

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		21819, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tg, mouse

Protein Ontology

More...PROi		PR:O08710
RNActiO08710, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000053469, Expressed in thyroid gland and 71 other tissues
ExpressionAtlasiO08710, baseline and differential
GenevisibleiO08710, MM

Family and domain databases

CDDicd00191, TY, 7 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 7 hits
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR016324, Thyroglobulin
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135, COesterase, 1 hit
PF07699, Ephrin_rec_like, 1 hit
PF00086, Thyroglobulin_1, 10 hits
PIRSFiPIRSF001831, Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411, Ephrin_rec_like, 1 hit
SM00211, TY, 10 hits
SUPFAMiSSF53474, SSF53474, 1 hit
SSF57610, SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 9 hits
PS51162, THYROGLOBULIN_1_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHYG_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08710
Secondary accession number(s): O88590, Q2NKY1, Q9QWY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 7, 2020
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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