UniProtKB - O08705 (NTCP_MOUSE)
Protein
Sodium/bile acid cotransporter
Gene
Slc10a1
Organism
Mus musculus (Mouse)
Status
Functioni
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
GO - Molecular functioni
- bile acid:sodium symporter activity Source: MGI
- bile acid transmembrane transporter activity Source: MGI
GO - Biological processi
- bile acid and bile salt transport Source: MGI
- bile acid signaling pathway Source: Ensembl
- cellular response to drug Source: Ensembl
- regulation of bile acid secretion Source: Ensembl
- regulation of gene expression Source: Ensembl
- response to 17alpha-ethynylestradiol Source: Ensembl
- response to ethanol Source: Ensembl
- response to nutrient levels Source: Ensembl
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-159418, Recycling of bile acids and salts |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/bile acid cotransporterAlternative name(s): Na(+)/bile acid cotransporter Na(+)/taurocholate transport protein Sodium/taurocholate cotransporting polypeptide Solute carrier family 10 member 1 |
Gene namesi | Name:Slc10a1 Synonyms:Ntcp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97379, Slc10a1 |
Subcellular locationi
Other locations
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 24 – 45 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 82 – 98 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 190 – 211 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 228 – 244 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 285 – 306 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052336 | 1 – 362 | Sodium/bile acid cotransporterAdd BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 271 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 330 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | O08705 |
MaxQBi | O08705 |
PaxDbi | O08705 |
PeptideAtlasi | O08705 |
PRIDEi | O08705 |
PTM databases
GlyGeni | O08705, 5 sites |
iPTMneti | O08705 |
PhosphoSitePlusi | O08705 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021135, Expressed in liver and 93 other tissues |
ExpressionAtlasi | O08705, baseline and differential |
Genevisiblei | O08705, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000093229 |
Miscellaneous databases
RNActi | O08705, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | O08705 |
OrthoDBi | 1148347at2759 |
PhylomeDBi | O08705 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030208, SLC10A1 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF40, PTHR10361:SF40, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O08705-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK
60 70 80 90 100
IKAHFWKPKG VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP
110 120 130 140 150
GGNLSNLFTL AMKGDMNLSI VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL
160 170 180 190 200
KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR PHYVPYVLKA GMIITFSLSV
210 220 230 240 250
AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL SALFRLNPSC
260 270 280 290 300
RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF
310 320 330 340 350
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL
360
SPNGLNSGQM AN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO35940 | O35940_MOUSE | Na/taurocholate cotransporting poly... | Slc10a1 Ntcp | 317 | Annotation score: | ||
A0A1W2P719 | A0A1W2P719_MOUSE | Sodium/bile acid cotransporter | Slc10a1 | 66 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB003303 mRNA Translation: BAA19846.1 U95131 mRNA Translation: AAB81023.1 BC021154 mRNA Translation: AAH21154.1 BC094023 mRNA Translation: AAH94023.1 |
CCDSi | CCDS49101.1 |
RefSeqi | NP_001171032.1, NM_001177561.1 XP_006515696.1, XM_006515633.3 |
Genome annotation databases
Ensembli | ENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135 ENSMUST00000218162; ENSMUSP00000151555; ENSMUSG00000021135 |
GeneIDi | 20493 |
KEGGi | mmu:20493 |
UCSCi | uc011yoj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB003303 mRNA Translation: BAA19846.1 U95131 mRNA Translation: AAB81023.1 BC021154 mRNA Translation: AAH21154.1 BC094023 mRNA Translation: AAH94023.1 |
CCDSi | CCDS49101.1 |
RefSeqi | NP_001171032.1, NM_001177561.1 XP_006515696.1, XM_006515633.3 |
3D structure databases
SMRi | O08705 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000093229 |
Chemistry databases
ChEMBLi | CHEMBL2073713 |
PTM databases
GlyGeni | O08705, 5 sites |
iPTMneti | O08705 |
PhosphoSitePlusi | O08705 |
Proteomic databases
jPOSTi | O08705 |
MaxQBi | O08705 |
PaxDbi | O08705 |
PeptideAtlasi | O08705 |
PRIDEi | O08705 |
Protocols and materials databases
Antibodypediai | 47330, 212 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135 ENSMUST00000218162; ENSMUSP00000151555; ENSMUSG00000021135 |
GeneIDi | 20493 |
KEGGi | mmu:20493 |
UCSCi | uc011yoj.1, mouse |
Organism-specific databases
CTDi | 6554 |
MGIi | MGI:97379, Slc10a1 |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | O08705 |
OrthoDBi | 1148347at2759 |
PhylomeDBi | O08705 |
TreeFami | TF315811 |
Enzyme and pathway databases
Reactomei | R-MMU-159418, Recycling of bile acids and salts |
Miscellaneous databases
BioGRID-ORCSi | 20493, 2 hits in 18 CRISPR screens |
ChiTaRSi | Slc10a1, mouse |
PROi | PR:O08705 |
RNActi | O08705, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021135, Expressed in liver and 93 other tissues |
ExpressionAtlasi | O08705, baseline and differential |
Genevisiblei | O08705, MM |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030208, SLC10A1 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF40, PTHR10361:SF40, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTCP_MOUSE | |
Accessioni | O08705Primary (citable) accession number: O08705 Secondary accession number(s): Q52L86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families