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Protein

Sodium/bile acid cotransporter

Gene

Slc10a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:Slc10a1
Synonyms:Ntcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:97379 Slc10a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 45HelicalSequence analysisAdd BLAST22
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei82 – 98HelicalSequence analysisAdd BLAST17
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei190 – 211HelicalSequence analysisAdd BLAST22
Transmembranei228 – 244HelicalSequence analysisAdd BLAST17
Transmembranei285 – 306HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523361 – 362Sodium/bile acid cotransporterAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei330PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO08705
PaxDbiO08705
PeptideAtlasiO08705
PRIDEiO08705

PTM databases

iPTMnetiO08705
PhosphoSitePlusiO08705

Expressioni

Gene expression databases

BgeeiENSMUSG00000021135 Expressed in 62 organ(s), highest expression level in liver
ExpressionAtlasiO08705 baseline and differential
GenevisibleiO08705 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093229

Structurei

3D structure databases

ProteinModelPortaliO08705
SMRiO08705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG101123
InParanoidiO08705
KOiK14341
OrthoDBiEOG091G0GT5
PhylomeDBiO08705
TreeFamiTF315811

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030208 SLC10A1
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF40 PTHR10361:SF40, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08705-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK
60 70 80 90 100
IKAHFWKPKG VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP
110 120 130 140 150
GGNLSNLFTL AMKGDMNLSI VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL
160 170 180 190 200
KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR PHYVPYVLKA GMIITFSLSV
210 220 230 240 250
AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL SALFRLNPSC
260 270 280 290 300
RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF
310 320 330 340 350
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL
360
SPNGLNSGQM AN
Length:362
Mass (Da):39,413
Last modified:July 1, 1997 - v1
Checksum:i7A70493E1804280F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O35940O35940_MOUSE
Na/taurocholate cotransporting poly...
Slc10a1 Ntcp, mCG_7625
317Annotation score:
A0A1W2P719A0A1W2P719_MOUSE
Sodium/bile acid cotransporter
Slc10a1
66Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003303 mRNA Translation: BAA19846.1
U95131 mRNA Translation: AAB81023.1
BC021154 mRNA Translation: AAH21154.1
BC094023 mRNA Translation: AAH94023.1
CCDSiCCDS49101.1
RefSeqiNP_001171032.1, NM_001177561.1
XP_006515696.1, XM_006515633.3
UniGeneiMm.486361

Genome annotation databases

EnsembliENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135
ENSMUST00000218162; ENSMUSP00000151555; ENSMUSG00000021135
GeneIDi20493
KEGGimmu:20493
UCSCiuc011yoj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003303 mRNA Translation: BAA19846.1
U95131 mRNA Translation: AAB81023.1
BC021154 mRNA Translation: AAH21154.1
BC094023 mRNA Translation: AAH94023.1
CCDSiCCDS49101.1
RefSeqiNP_001171032.1, NM_001177561.1
XP_006515696.1, XM_006515633.3
UniGeneiMm.486361

3D structure databases

ProteinModelPortaliO08705
SMRiO08705
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093229

Chemistry databases

ChEMBLiCHEMBL2073713

PTM databases

iPTMnetiO08705
PhosphoSitePlusiO08705

Proteomic databases

MaxQBiO08705
PaxDbiO08705
PeptideAtlasiO08705
PRIDEiO08705

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135
ENSMUST00000218162; ENSMUSP00000151555; ENSMUSG00000021135
GeneIDi20493
KEGGimmu:20493
UCSCiuc011yoj.1 mouse

Organism-specific databases

CTDi6554
MGIiMGI:97379 Slc10a1

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG101123
InParanoidiO08705
KOiK14341
OrthoDBiEOG091G0GT5
PhylomeDBiO08705
TreeFamiTF315811

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts

Miscellaneous databases

ChiTaRSiSlc10a1 mouse
PROiPR:O08705
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021135 Expressed in 62 organ(s), highest expression level in liver
ExpressionAtlasiO08705 baseline and differential
GenevisibleiO08705 MM

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030208 SLC10A1
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF40 PTHR10361:SF40, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP_MOUSE
AccessioniPrimary (citable) accession number: O08705
Secondary accession number(s): Q52L86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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