UniProtKB - O08705 (NTCP_MOUSE)

BLAST

>sp|O08705|NTCP_MOUSE Sodium/bile acid cotransporter OS=Mus musculus OX=10090 GN=Slc10a1 PE=1 SV=1
MEAHNVSAPFNFSLPPGFGHRATDTALSVILVVMLLLIMLSLGCTMEFSKIKAHFWKPKG
VIIAIVAQYGIMPLSAFLLGKVFHLTSIEALAILICGCSPGGNLSNLFTLAMKGDMNLSI
VMTTCSSFTALGMMPLLLYIYSKGIYDGDLKDKVPYKGIMLSLVMVLIPCAIGIFLKSKR
PHYVPYVLKAGMIITFSLSVAVTVLSVINVGNSIMFVMTPHLLATSSLMPFTGFLMGYIL
SALFRLNPSCRRTISMETGFQNVQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLF
IIIFRCYLKIKPQKDQTKITYKAAATEDATPAALEKGTHNGNNPPTQPGLSPNGLNSGQM
AN

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History
Entry version 138 (07 Nov 2018)
Sequence version 1 (01 Jul 1997)
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Protein

Sodium/bile acid cotransporter

Gene

Slc10a1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

GO - Molecular functionⁱ

bile acid:sodium symporter activity Source: MGI
bile acid transmembrane transporter activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bile acid and bile salt transport Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Sodium transport, Symport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-159418 Recycling of bile acids and salts

Reactomeⁱ

R-MMU-159418 Recycling of bile acids and salts

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium/bile acid cotransporter Alternative name(s): Na(+)/bile acid cotransporter Na(+)/taurocholate transport protein Sodium/taurocholate cotransporting polypeptide Solute carrier family 10 member 1
Gene namesⁱ	Name:Slc10a1 Synonyms:Ntcp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:97379 Slc10a1

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	24 – 45	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	82 – 98	HelicalSequence analysisAdd BLAST	17
Transmembraneⁱ	158 – 178	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	190 – 211	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	228 – 244	HelicalSequence analysisAdd BLAST	17
Transmembraneⁱ	285 – 306	HelicalSequence analysisAdd BLAST	22

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2073713

ChEMBLⁱ

CHEMBL2073713

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000052336	1 – 362	Sodium/bile acid cotransporterAdd BLAST		362

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	271	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	330	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O08705
PaxDbⁱ	O08705
PeptideAtlas More...PeptideAtlasⁱ	O08705
PRIDEⁱ	O08705

PTM databases

iPTMnetⁱ	O08705
PhosphoSitePlusⁱ	O08705

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021135 Expressed in 62 organ(s), highest expression level in liver
ExpressionAtlasⁱ	O08705 baseline and differential
Genevisibleⁱ	O08705 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000093229

STRINGⁱ

10090.ENSMUSP00000093229

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08705
SMRⁱ	O08705
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2718 Eukaryota COG0385 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074505
HOGENOMⁱ	HOG000234524
HOVERGENⁱ	HBG101123
InParanoidⁱ	O08705
KEGG Orthology (KO) More...KOⁱ	K14341
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GT5
PhylomeDBⁱ	O08705
TreeFamⁱ	TF315811

Family and domain databases

Gene3Dⁱ	1.20.1530.20, 1 hit
InterProⁱ	View protein in InterPro IPR002657 BilAc:Na_symport/Acr3 IPR004710 Bilac:Na_transpt IPR038770 Na+/solute_symporter_sf IPR030208 SLC10A1
PANTHERⁱ	PTHR10361 PTHR10361, 1 hit PTHR10361:SF40 PTHR10361:SF40, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01758 SBF, 1 hit
TIGRFAMsⁱ	TIGR00841 bass, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O08705-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK 
        60         70         80         90        100
IKAHFWKPKG VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP 
       110        120        130        140        150
GGNLSNLFTL AMKGDMNLSI VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL 
       160        170        180        190        200
KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR PHYVPYVLKA GMIITFSLSV 
       210        220        230        240        250
AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL SALFRLNPSC 
       260        270        280        290        300
RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF 
       310        320        330        340        350
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL 
       360 
SPNGLNSGQM AN

Length:362

Mass (Da):39,413

Last modified:July 1, 1997 - v1

Checksum:ⁱ7A70493E1804280F

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

O35940	O35940_MOUSE	Na/taurocholate cotransporting poly... Na/taurocholate cotransporting polypeptide 2 (Sodium/bile acid cotransporter) (Solute carrier family 10 (Sodium/bile acid cotransporter family), member 1, isoform CRA_d)	Slc10a1 Ntcp, mCG_7625	317	Annotation score:
A0A1W2P719	A0A1W2P719_MOUSE	Sodium/bile acid cotransporter Sodium/bile acid cotransporter	Slc10a1	66	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB003303 mRNA Translation: BAA19846.1 U95131 mRNA Translation: AAB81023.1 BC021154 mRNA Translation: AAH21154.1 BC094023 mRNA Translation: AAH94023.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49101.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001171032.1, NM_001177561.1 XP_006515696.1, XM_006515633.3
UniGeneⁱ	Mm.486361

Genome annotation databases

Ensemblⁱ	ENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135 ENSMUST00000218162; ENSMUSP00000151555; ENSMUSG00000021135
GeneIDⁱ	20493
KEGGⁱ	mmu:20493
UCSC genome browser More...UCSCⁱ	uc011yoj.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08705	Sodium/bile acid cotransporter		RAT		362	UniRef90_P26435
UPI000A3119A9		MUSPA		362
UPI000A31B09D		MUSCR		362
Sodium-dependent bile acid cotransporter (Fragment)		RAT		82

Protein	Similar proteins		Species	Score	Length	Source
O08705	Sodium/bile acid cotransporter		RAT		362	UniRef50_P26435
Uncharacterized protein		NEOLE		318
Na/taurocholate cotransporting polypeptide 2		MOUSE		317
Sodium/bile acid cotransporter		Bengalese finch		344
Sodium/bile acid cotransporter		Patagioenas fasciata monilis		356
+90

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB003303 mRNA Translation: BAA19846.1 U95131 mRNA Translation: AAB81023.1 BC021154 mRNA Translation: AAH21154.1 BC094023 mRNA Translation: AAH94023.1
CCDSⁱ	CCDS49101.1
RefSeqⁱ	NP_001171032.1, NM_001177561.1 XP_006515696.1, XM_006515633.3
UniGeneⁱ	Mm.486361

3D structure databases

ProteinModelPortalⁱ	O08705
SMRⁱ	O08705
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000093229

STRINGⁱ

10090.ENSMUSP00000093229

Chemistry databases

ChEMBLⁱ	CHEMBL2073713

ChEMBLⁱ

CHEMBL2073713

PTM databases

iPTMnetⁱ	O08705
PhosphoSitePlusⁱ	O08705

Proteomic databases

MaxQBⁱ	O08705
PaxDbⁱ	O08705
PeptideAtlasⁱ	O08705
PRIDEⁱ	O08705

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135 ENSMUST00000218162; ENSMUSP00000151555; ENSMUSG00000021135
GeneIDⁱ	20493
KEGGⁱ	mmu:20493
UCSCⁱ	uc011yoj.1 mouse

Organism-specific databases

CTDⁱ	6554
MGIⁱ	MGI:97379 Slc10a1

Phylogenomic databases

eggNOGⁱ	KOG2718 Eukaryota COG0385 LUCA
GeneTreeⁱ	ENSGT00550000074505
HOGENOMⁱ	HOG000234524
HOVERGENⁱ	HBG101123
InParanoidⁱ	O08705
KOⁱ	K14341
OrthoDBⁱ	EOG091G0GT5
PhylomeDBⁱ	O08705
TreeFamⁱ	TF315811

Enzyme and pathway databases

Reactomeⁱ	R-MMU-159418 Recycling of bile acids and salts

Reactomeⁱ

R-MMU-159418 Recycling of bile acids and salts

Miscellaneous databases

ChiTaRSⁱ	Slc10a1 mouse
Protein Ontology More...PROⁱ	PR:O08705
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021135 Expressed in 62 organ(s), highest expression level in liver
ExpressionAtlasⁱ	O08705 baseline and differential
Genevisibleⁱ	O08705 MM

Family and domain databases

Gene3Dⁱ	1.20.1530.20, 1 hit
InterProⁱ	View protein in InterPro IPR002657 BilAc:Na_symport/Acr3 IPR004710 Bilac:Na_transpt IPR038770 Na+/solute_symporter_sf IPR030208 SLC10A1
PANTHERⁱ	PTHR10361 PTHR10361, 1 hit PTHR10361:SF40 PTHR10361:SF40, 1 hit
Pfamⁱ	View protein in Pfam PF01758 SBF, 1 hit
TIGRFAMsⁱ	TIGR00841 bass, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NTCP_MOUSE
Accessionⁱ	O08705Primary (citable) accession number: O08705 Secondary accession number(s): Q52L86
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniProtKB - O08705 (NTCP_MOUSE)

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Sodium/bile acid cotransporter

Slc10a1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ