Forkhead box protein M1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain."
    Yao K.-M., Sha M., Lu Z., Wong G.G.
    J. Biol. Chem. 272:19827-19836(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation."
    Luscher-Firzlaff J.M., Westendorf J.M., Zwicker J., Burkhardt H., Henriksson M., Muller R., Pirollet F., Luscher B.
    Oncogene 18:5620-5630(1999) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: MGI
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGI
• transcription regulatory region sequence-specific DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression."
    Malin D., Kim I.M., Boetticher E., Kalin T.V., Ramakrishna S., Meliton L., Ustiyan V., Zhu X., Kalinichenko V.V.
    Mol Cell Biol 27:2486-2498(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.2

    "Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
    Tan Y., Raychaudhuri P., Costa R.H.
    Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN DNA REPAIR.
• DNA repair Source: UniProtKB-KW
• G2/M transition of mitotic cell cycle Source: UniProtKB
• liver development Source: MGIInferred from mutant phenotypeⁱ
  • "The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis."
    Krupczak-Hollis K., Wang X., Kalinichenko V.V., Gusarova G.A., Wang I.C., Dennewitz M.B., Yoder H.M., Kiyokawa H., Kaestner K.H., Costa R.H.
    Dev Biol 276:74-88(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell aging Source: MGI
• negative regulation of stress-activated MAPK cascade Source: MGI
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature."
    Kim I.M., Ramakrishna S., Gusarova G.A., Yoder H.M., Costa R.H., Kalinichenko V.V.
    J Biol Chem 280:22278-22286(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of double-strand break repair Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.2

    "Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
    Tan Y., Raychaudhuri P., Costa R.H.
    Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN DNA REPAIR.
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.2

    "Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
    Tan Y., Raychaudhuri P., Costa R.H.
    Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN DNA REPAIR.
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature."
    Kim I.M., Ramakrishna S., Gusarova G.A., Yoder H.M., Costa R.H., Kalinichenko V.V.
    J Biol Chem 280:22278-22286(2005) [PubMed] [Europe PMC] [Abstract]
  • "Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression."
    Malin D., Kim I.M., Boetticher E., Kalin T.V., Ramakrishna S., Meliton L., Ustiyan V., Zhu X., Kalinichenko V.V.
    Mol Cell Biol 27:2486-2498(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle arrest Source: MGI
• regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis."
    Krupczak-Hollis K., Wang X., Kalinichenko V.V., Gusarova G.A., Wang I.C., Dennewitz M.B., Yoder H.M., Kiyokawa H., Kaestner K.H., Costa R.H.
    Dev Biol 276:74-88(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of Ras protein signal transduction Source: MGI
• regulation of reactive oxygen species metabolic process Source: MGI
• vasculogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature."
    Kim I.M., Ramakrishna S., Gusarova G.A., Yoder H.M., Costa R.H., Kalinichenko V.V.
    J Biol Chem 280:22278-22286(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRTSPRRPLI LKRRRLPLPV QNAPSETSEE EAKRSPAQPE PAPAQASQEV 
        60         70         80         90        100
AESSSCKFPA GIKIINHPTT PNTQVVAIPS NADIQSIITA LTAKGKESGT 
       110        120        130        140        150
SGPNRFILIS SGGPSSHPSQ PQAHSSRDSK RAEVITETLG PKPAAKGVPV 
       160        170        180        190        200
PKPPGAPPRQ RQESYAGGEA AGCTLDNSLT NIQWLGKMSS DGLGPCSVKQ 
       210        220        230        240        250
ELEEKENCHL EQNRVKVEEP SGVSTSWQDS VSERPPYSYM AMIQFAINST 
       260        270        280        290        300
ERKRMTLKDI YTWIEDHFPY FKHIAKPGWK NSIRHNLSLH DMFVRETSAN 
       310        320        330        340        350
GKVSFWTIHP SANRHLTLDQ VFKPLEPGSP QSPEHLESQQ KRPNPELHRN 
       360        370        380        390        400
VTIKTEIPLG ARRKMKPLLP RVSSYLEPIQ FPVNQSLVLQ PSVKVPFRLA 
       410        420        430        440        450
ASLMSSELAR HSKRVRIAPK VLLSSEGIAP LPATEPPKEE KPLLGGEGLL 
       460        470        480        490        500
PLLPIQSIKE EEMQPEEDIA HLERPIKVES PPLEEWPSPC ASLKEELSNS 
       510        520        530        540        550
WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV SRSRRKQHLQ 
       560        570        580        590        600
PPCLDEPDLF FPEDSSTFRP AVELLAESSE PAPHLSCPQE EGGPFKTPIK 
       610        620        630        640        650
ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGLLPDS 
       660        670        680        690        700
LGLMELNTTP LKSGPLFDSP RELLNSEPFD LASDPFGSPP PPHVEGPKPG 
       710        720        730        740        750
SPELQIPSLS ANRSLTEGLV LDTMNDSLSK ILLDISFPGL EEDPLGPDNI 
       760
NWSQFIPELR                                             

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot