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Protein

Proteinase-activated receptor 3

Gene

F2rl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • thrombin-activated receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase-activated receptor 3
Short name:
PAR-3
Alternative name(s):
Coagulation factor II receptor-like 2
Thrombin receptor-like 2
Gene namesi
Name:F2rl2
Synonyms:Par3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298208 F2rl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 93ExtracellularSequence analysisAdd BLAST56
Transmembranei94 – 119Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini120 – 127CytoplasmicSequence analysis8
Transmembranei128 – 147Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini148 – 166ExtracellularSequence analysisAdd BLAST19
Transmembranei167 – 188Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini189 – 205CytoplasmicSequence analysisAdd BLAST17
Transmembranei206 – 229Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini230 – 259ExtracellularSequence analysisAdd BLAST30
Transmembranei260 – 279Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini280 – 296CytoplasmicSequence analysisAdd BLAST17
Transmembranei297 – 321Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini322 – 335ExtracellularSequence analysisAdd BLAST14
Transmembranei336 – 360Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini361 – 369CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001275820 – 37Removed for receptor activationBy similarityAdd BLAST18
ChainiPRO_000001275938 – 369Proteinase-activated receptor 3Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 244PROSITE-ProRule annotation

Post-translational modificationi

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37 – 38Cleavage; by thrombinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO08675
PaxDbiO08675
PRIDEiO08675

PTM databases

iPTMnetiO08675
PhosphoSitePlusiO08675

Expressioni

Gene expression databases

BgeeiENSMUSG00000021675 Expressed in 69 organ(s), highest expression level in blood
CleanExiMM_F2RL2
GenevisibleiO08675 MM

Interactioni

Subunit structurei

Interacts with INSC/inscuteable and GPSM2.1 Publication

Protein-protein interaction databases

DIPiDIP-41474N
IntActiO08675, 1 interactor
MINTiO08675
STRINGi10090.ENSMUSP00000022182

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO08675
SMRiO08675
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08675

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJUX Eukaryota
ENOG4111GWA LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000116291
HOVERGENiHBG105658
InParanoidiO08675
KOiK04235
OMAiSAIEGWT
OrthoDBiEOG091G0C2F
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003943 Prot_act_rcpt_3
IPR003912 Protea_act_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR00237 GPCRRHODOPSN
PR01428 PROTEASEAR
PR01429 PROTEASEAR3
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08675-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILILVAAG LLFLPVTVCQ SGINVSDNSA KPTLTIKSFN GGPQNTFEEF
60 70 80 90 100
PLSDIEGWTG ATTTIKAECP EDSISTLHVN NATIGYLRSS LSTQVIPAIY
110 120 130 140 150
ILLFVVGVPA NIVTLWKLSL RTKSISLVIF HTNLAIADLL FCVTLPFKIA
160 170 180 190 200
YHLNGNNWVF GEVTCRITTV VFYGNMYCAI LILTCMGINR YLATAHPFTY
210 220 230 240 250
QKLPKRSFSM LMCGMVWVMV FLYMLPFVIL KQEYHLVHSE ITTCHDVVDA
260 270 280 290 300
CESPSSFRFY YFVSLAFFGF LIPFVIIIFC YTTLIHKLKS KDRIWLGYIK
310 320 330 340 350
AVLLILVIFT ICFAPTNIIL VIHHANYYYH NTDSLYFMYL IALCLGSLNS
360
CLDPFLYFVM SKVVDQLNP
Length:369
Mass (Da):41,697
Last modified:July 27, 2011 - v2
Checksum:iC8E6B0097F0BF90F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110A → S in AAC53137 (PubMed:9087410).Curated1
Sequence conflicti110A → S in AAI40986 (PubMed:15489334).Curated1
Sequence conflicti164T → M in AAC53137 (PubMed:9087410).Curated1
Sequence conflicti164T → M in AAI40986 (PubMed:15489334).Curated1
Sequence conflicti210M → L in AAC53137 (PubMed:9087410).Curated1
Sequence conflicti210M → L in AAI40986 (PubMed:15489334).Curated1
Sequence conflicti215M → I in AAC53137 (PubMed:9087410).Curated1
Sequence conflicti215M → I in AAI40986 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92972 mRNA Translation: AAC53137.1
AK135212 mRNA Translation: BAE22460.1
BC140985 mRNA Translation: AAI40986.1
CCDSiCCDS26702.1
RefSeqiNP_034300.3, NM_010170.4
UniGeneiMm.440952

Genome annotation databases

EnsembliENSMUST00000022182; ENSMUSP00000022182; ENSMUSG00000021675
GeneIDi14064
KEGGimmu:14064
UCSCiuc007rmq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92972 mRNA Translation: AAC53137.1
AK135212 mRNA Translation: BAE22460.1
BC140985 mRNA Translation: AAI40986.1
CCDSiCCDS26702.1
RefSeqiNP_034300.3, NM_010170.4
UniGeneiMm.440952

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PUXX-ray2.00C44-56[»]
ProteinModelPortaliO08675
SMRiO08675
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-41474N
IntActiO08675, 1 interactor
MINTiO08675
STRINGi10090.ENSMUSP00000022182

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO08675
PhosphoSitePlusiO08675

Proteomic databases

MaxQBiO08675
PaxDbiO08675
PRIDEiO08675

Protocols and materials databases

DNASUi14064
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022182; ENSMUSP00000022182; ENSMUSG00000021675
GeneIDi14064
KEGGimmu:14064
UCSCiuc007rmq.1 mouse

Organism-specific databases

CTDi2151
MGIiMGI:1298208 F2rl2

Phylogenomic databases

eggNOGiENOG410IJUX Eukaryota
ENOG4111GWA LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000116291
HOVERGENiHBG105658
InParanoidiO08675
KOiK04235
OMAiSAIEGWT
OrthoDBiEOG091G0C2F
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)

Miscellaneous databases

EvolutionaryTraceiO08675
PROiPR:O08675
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021675 Expressed in 69 organ(s), highest expression level in blood
CleanExiMM_F2RL2
GenevisibleiO08675 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003943 Prot_act_rcpt_3
IPR003912 Protea_act_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR00237 GPCRRHODOPSN
PR01428 PROTEASEAR
PR01429 PROTEASEAR3
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAR3_MOUSE
AccessioniPrimary (citable) accession number: O08675
Secondary accession number(s): B9EIT2, Q3UXV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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