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Entry version 129 (02 Dec 2020)
Sequence version 1 (01 Jul 1997)
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Protein

Nuclear pore complex protein Nup88

Gene

Nup88

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of nuclear pore complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-159227, Transport of the SLBP independent Mature mRNA
R-RNO-159230, Transport of the SLBP Dependant Mature mRNA
R-RNO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859, snRNP Assembly
R-RNO-3108214, SUMOylation of DNA damage response and repair proteins
R-RNO-3232142, SUMOylation of ubiquitinylation proteins
R-RNO-3301854, Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453, Regulation of HSF1-mediated heat shock response
R-RNO-4085377, SUMOylation of SUMOylation proteins
R-RNO-4551638, SUMOylation of chromatin organization proteins
R-RNO-4570464, SUMOylation of RNA binding proteins
R-RNO-4615885, SUMOylation of DNA replication proteins
R-RNO-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup84
Nucleoporin Nup88
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup88
Synonyms:Nup84
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
620182, Nup88

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048892 – 742Nuclear pore complex protein Nup88Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei518PhosphoserineCombined sources1
Modified residuei541PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O08658

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08658

PRoteomics IDEntifications database

More...
PRIDEi
O08658

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08658

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08658

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000006126, Expressed in testis and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O08658, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NUP214/CAN.

Interacts with NUP62 and NUP98 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O08658

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009015

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08658

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili597 – 652Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4460, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017144_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08658

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCSIMCL

Database of Orthologous Groups

More...
OrthoDBi
1149034at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O08658

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019321, Nucleoporin_Nup88
IPR037700, NUP88/NUP82

The PANTHER Classification System

More...
PANTHERi
PTHR13257, PTHR13257, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10168, Nup88, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O08658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAGPVGD GELWQSWLPN HVVFLRLREG LKNQSPAEAD KPATSTSPSC
60 70 80 90 100
PPLPPHLPTR NLVFGLGGEL FLWDAEGSAF LVVRLRGPSG GSVEPPLSQY
110 120 130 140 150
QRLLCINPPL FEIHQVLLSP TQHHVALIGT KGLMALELPQ RWGKDSEFEG
160 170 180 190 200
GKATVNCSTI PIAERFFTSS TSLTLKHAAW YPSEMLDPHI VLLTSDNVIR
210 220 230 240 250
IYSLREPQTP TKVIVLSEAE EESLILNKGR AYTASLGETA VAFDFGPLVT
260 270 280 290 300
VSKNMFEQKD REAVAYPLYI LYENGETFLT YVSLLHSPGN IGKLLGPLPM
310 320 330 340 350
HPAAEDNYGY DACAILCLPC VPNILVIATE SGMLYHCVVL EGEEDDDQTL
360 370 380 390 400
EKSWDPRADL IPSLYVFECV ELELALKLAS AEDDPFASDF SCPIKLHRDP
410 420 430 440 450
KCPSRYHCSH EAGVHSVGLT WIHKLHKFLG SDEEDKDSLQ ELTAEQKCFV
460 470 480 490 500
EHILCTKPLP CRQPAPIRGF WIVPDILGPT MICITSTYEC LIRPLLSTVH
510 520 530 540 550
PASPPLLCTR EDAGVAESPL RILAEAPDSF EKHIKRILQR SAANPALLKS
560 570 580 590 600
SEKDLAPPPE ECLQLISRAT QVFREQYILK QDLAKEEIQR RVKLLCDQKR
610 620 630 640 650
KQLEDLNYCR EERKSLREMA ERLADKYEEA KEKQEDIMNR MKKVLHSFHT
660 670 680 690 700
QLPVLSDSER DMKKELQLIP DQLRHLGNAI KQVTMKKDYQ QRKMEKVLSP
710 720 730 740
QKPTITLSAY QRKCIQSILK EEGEHIREMV KQINDIRNHV NF
Length:742
Mass (Da):83,585
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2C38D0DCEFFB3D8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U93692 mRNA Translation: AAB52419.1
BC072524 mRNA Translation: AAH72524.1

NCBI Reference Sequences

More...
RefSeqi
NP_446068.1, NM_053616.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000009015; ENSRNOP00000009015; ENSRNOG00000006126

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113929

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:113929

UCSC genome browser

More...
UCSCi
RGD:620182, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93692 mRNA Translation: AAB52419.1
BC072524 mRNA Translation: AAH72524.1
RefSeqiNP_446068.1, NM_053616.1

3D structure databases

SMRiO08658
ModBaseiSearch...

Protein-protein interaction databases

CORUMiO08658
STRINGi10116.ENSRNOP00000009015

PTM databases

iPTMnetiO08658
PhosphoSitePlusiO08658

Proteomic databases

jPOSTiO08658
PaxDbiO08658
PRIDEiO08658

Genome annotation databases

EnsembliENSRNOT00000009015; ENSRNOP00000009015; ENSRNOG00000006126
GeneIDi113929
KEGGirno:113929
UCSCiRGD:620182, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4927
RGDi620182, Nup88

Phylogenomic databases

eggNOGiKOG4460, Eukaryota
GeneTreeiENSGT00390000015063
HOGENOMiCLU_017144_0_0_1
InParanoidiO08658
OMAiSCSIMCL
OrthoDBi1149034at2759
PhylomeDBiO08658

Enzyme and pathway databases

ReactomeiR-RNO-159227, Transport of the SLBP independent Mature mRNA
R-RNO-159230, Transport of the SLBP Dependant Mature mRNA
R-RNO-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-RNO-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-RNO-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-RNO-191859, snRNP Assembly
R-RNO-3108214, SUMOylation of DNA damage response and repair proteins
R-RNO-3232142, SUMOylation of ubiquitinylation proteins
R-RNO-3301854, Nuclear Pore Complex (NPC) Disassembly
R-RNO-3371453, Regulation of HSF1-mediated heat shock response
R-RNO-4085377, SUMOylation of SUMOylation proteins
R-RNO-4551638, SUMOylation of chromatin organization proteins
R-RNO-4570464, SUMOylation of RNA binding proteins
R-RNO-4615885, SUMOylation of DNA replication proteins
R-RNO-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O08658

Gene expression databases

BgeeiENSRNOG00000006126, Expressed in testis and 21 other tissues
GenevisibleiO08658, RN

Family and domain databases

InterProiView protein in InterPro
IPR019321, Nucleoporin_Nup88
IPR037700, NUP88/NUP82
PANTHERiPTHR13257, PTHR13257, 1 hit
PfamiView protein in Pfam
PF10168, Nup88, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP88_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08658
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 1, 1997
Last modified: December 2, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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