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Entry version 142 (02 Dec 2020)
Sequence version 1 (01 Jul 1997)
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Protein

Telomerase protein component 1

Gene

Tep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1181 – 1188ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomerase protein component 1
Short name:
rTLP1
Alternative name(s):
Telomerase-associated protein 1
Short name:
Telomerase protein 1
p230
p240
p80 telomerase homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tep1
Synonyms:Tlp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3869, Tep1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509841 – 2629Telomerase protein component 1Add BLAST2629

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08653

PRoteomics IDEntifications database

More...
PRIDEi
O08653

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
O08653

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08653

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08653

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associated component of the telomerase holoenzyme complex (By similarity).

Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000012235

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 30TEP1 N-terminal 1PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati31 – 60TEP1 N-terminal 2PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati61 – 90TEP1 N-terminal 3PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati91 – 120TEP1 N-terminal 4PROSITE-ProRule annotation1 PublicationAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini231 – 689TROVEPROSITE-ProRule annotationAdd BLAST459
Domaini1175 – 1582NACHTPROSITE-ProRule annotationAdd BLAST408
Repeati1424 – 1461WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati1685 – 1724WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1727 – 1765WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati1768 – 1807WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1809 – 1848WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1851 – 1890WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1893 – 1934WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST42
Repeati1936 – 1975WD 8PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1978 – 2016WD 9PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati2019 – 2058WD 10PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati2070 – 2109WD 11PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati2116 – 2154WD 12PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati2157 – 2194WD 13PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati2200 – 2244WD 14PROSITE-ProRule annotation1 PublicationAdd BLAST45
Repeati2247 – 2285WD 15PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati2288 – 2327WD 16PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati2329 – 2365WD 17PROSITE-ProRule annotation1 PublicationAdd BLAST37
Repeati2378 – 2427WD 18PROSITE-ProRule annotation1 PublicationAdd BLAST50
Repeati2470 – 2510WD 19PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati2555 – 2592WD 20PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati2594 – 2628WD 21PROSITE-ProRule annotation1 PublicationAdd BLAST35

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3602, Eukaryota
KOG4155, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08653

Database of Orthologous Groups

More...
OrthoDBi
29963at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O08653

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025139, DUF4062
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase
IPR008850, TEP1_N
IPR008858, TROVE_dom
IPR037214, TROVE_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13271, DUF4062, 1 hit
PF05729, NACHT, 1 hit
PF05386, TEP1_N, 4 hits
PF05731, TROVE, 1 hit
PF00400, WD40, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140864, SSF140864, 1 hit
SSF50978, SSF50978, 4 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50837, NACHT, 1 hit
PS51226, TEP1_N, 4 hits
PS50988, TROVE, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 7 hits
PS50294, WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLCGYVPV HPDILSLKNR CLTMLSDIQP LEKIHGQRSV NPDILSLENR
60 70 80 90 100
CLTLLPDLQP MEKIHGQRSV HPDILSSENR CLTLLPDLQS LEKLCGHMSS
110 120 130 140 150
HPDVLSLENR CLATLPTVKR TVSSGPLLQC LHRSHTAQAD LRDPNFRNCL
160 170 180 190 200
FPEPPTIEAP CFLKELDLPT GPRALKSMSA TARVQEVALG QRCVSEGKEL
210 220 230 240 250
QEEKESAEVP MPLYSLSLGG EEEEVVGAPV LKLTSGDSDS HPETTDQILQ
260 270 280 290 300
EKKMALLTLL CSAMASSVNV KDASDPTRAS IHEVCSALAP LEPEFILKAS
310 320 330 340 350
LYARQQLNLR DIANIVLAVA ALLPACRPHV RRYYSAIVHL PSDWIQVAEF
360 370 380 390 400
YQSLAEGDEK KLVPLPACLR AAMTDKFAQF DEYQLAKYNP RKHRSKTRSR
410 420 430 440 450
QPPRPQRTKP PFSESGKCFP KSVWPLKNEQ ISFEAAYNAV SEKKRLPRFT
460 470 480 490 500
LKKLVEQLHI HEPAQHVQAL LGYRYPSTLE LFSRSHLPGP WDSSRAGQRM
510 520 530 540 550
KLQRPETWER ELSLRGNRAS VWEELIDNGK LPFMAMLRNL CNLLRTGISA
560 570 580 590 600
HHHELVLQRL QHEKSVIHSR QFPFRFLNAH DSLDRLEAQL RSKASPFPSN
610 620 630 640 650
TTLMKRIMIR NSKKIKRPAN PRYLCTLTQR QLRAAMAIPV MYEHLKREKL
660 670 680 690 700
RLHKARQWTC DLELLERYRQ ALETAVNISV KHNLPPLPGR TLLVYLTDAN
710 720 730 740 750
ANRLCPKSHL QGPPLNYVLL LIGMMMARAE QTTVWLCGTG TVKTPVLTAD
760 770 780 790 800
EGILKTAIKL QAQVQELEEN DEWPLETFEK YLLSLAVRRT PIDRVILFGQ
810 820 830 840 850
RMDTELLNVA KQIIWQHVNS KCLFVSVLLR KMQYMSPNLN PNDVTLSGCT
860 870 880 890 900
DGILKFIAEH GASRLLEHVG QLDKIFKIPP PPGKTKVSPL RPLEENNPGP
910 920 930 940 950
FVPISQHGWR NIRLFISSTF RDMHGERDLL MRSVLPALQA RAFPHRISLH
960 970 980 990 1000
AIDLRWGITE EETRRNRQLE VCLGEVENSQ LFVGILGSRY GYTPPSYDLP
1010 1020 1030 1040 1050
DHPHFHWTQR YPSGRSVTEM EVMQFLNRGQ RSEPSDQALI YFRDPGFLSS
1060 1070 1080 1090 1100
VPDVWKPDFI SESEEAAHRV SELKRFLQEQ KEVTCRRYSC EWGGVAAGRP
1110 1120 1130 1140 1150
YTGGLEEFGQ LVLQDVWSVI QKRYLQPGAQ LEQPGSISEE DLIQASFQQL
1160 1170 1180 1190 1200
KSPPSPARPR LLQDTVQQLM LPHGRLSLVI GQAGQGKTAF LASLVSALKV
1210 1220 1230 1240 1250
PDQPNVAPFV FFHFSAARPD QCLAFNLLRR LCTHLHQKLG EPSALPSTYR
1260 1270 1280 1290 1300
GLVWELQQKL LLKSAQWLQP GQTLVLIIDG ADKLVDHNGQ LISDWIPKSL
1310 1320 1330 1340 1350
PRRVHLVLSV SSDSGLGETL QQSQSAYVVA LGSLVPSSRA QLVREELALY
1360 1370 1380 1390 1400
GKRLEESPFN NQMRLLLAKQ GSSLPLYLHL VTDYLRLFTL YEQVSERLRT
1410 1420 1430 1440 1450
LPATLPLLLQ HILSTLEQEH GHNVLPQALT ALEVTHSGLT VDQLHAVLST
1460 1470 1480 1490 1500
WLTLPKETKS WEEAVAASHS GNLYPLAPFA YLVQSLRSLL GEGPVERPGA
1510 1520 1530 1540 1550
RLCLSDGPLR TAVKRRYGKR LGLEKTAHVL IAAHLWKMCD PDASGTFRSC
1560 1570 1580 1590 1600
PPEALKDLPY HLLQSGNHGL LAKFLTNLHV VAAYLEVGLV PDLLEAYELY
1610 1620 1630 1640 1650
ASSKPEVNQK LPEADVAVFH NFLKQQASLL TQYPLLLLQQ AASQPEESPV
1660 1670 1680 1690 1700
CCQAPLLTQR WHNQCILKWI NKPQTLKGQQ SLSLPISSSP TAVAFSPNGQ
1710 1720 1730 1740 1750
RAAVGTAGGT IYLLNLRTWQ EEKALVSGCD GISSFAFLSD TALFLTTFDG
1760 1770 1780 1790 1800
LLELWDLQHG CWVFQTKAHQ YQITGCCLSP DRRLLATVCL GGYVKLWDTV
1810 1820 1830 1840 1850
QGQLAFQYTH PKSLNCITFH PEGQVVATGN WSGIVTFFQA DGLKVTKELG
1860 1870 1880 1890 1900
GPGPSVRTLA FSAPGKVVAL GRIDGTVELW AWQEGTRLAA FPAQCGGVST
1910 1920 1930 1940 1950
VLFLHAGGRF LTAGEDGKAQ LWSGFLGRPR GCLGSLYLSP ALSVALNPDG
1960 1970 1980 1990 2000
DQVAVGYRGD GIKIYRISSG PQEAQCQELN VAVSALVWLS PSVLVSGAED
2010 2020 2030 2040 2050
GSLHGWMLRR NSLQSLWLSS VCQKPVLGLA ASQEFLASAS EDFTVRLWPR
2060 2070 2080 2090 2100
QLLTQPHAVE ELPCAAELRG HEGPVCCCSF SPDGRILATA GRDRNLLCWD
2110 2120 2130 2140 2150
VKVAQAPLLI HTFSSCHRDW ITGCTWTKDN ILISCSSDGS VGLWNPEAGQ
2160 2170 2180 2190 2200
QLGQFPGHQS AVSAVVAVEE HIVSVSRDGT LKVWDRQGVE LTSIPAHSGP
2210 2220 2230 2240 2250
ISQCAAALEP RPAGQPGSEL MVVTVGLDGA TKLWHPLLVC QIHTLQGHSG
2260 2270 2280 2290 2300
PVTAAAASEA SGLLLTSDNS SVRLWQIPKE ADDTCKPRSS AVITAVAWAP
2310 2320 2330 2340 2350
DGSLVVSGNE AGELTLWQKA QAVATARAPG RVSDLIWCSA NAFFVLSANE
2360 2370 2380 2390 2400
NVSEWQVELR KGSTCTNFRL YLKRVLQEDL GVLTGMALAP DGQSLILMKE
2410 2420 2430 2440 2450
DVELLQMKPG STPSSICRRY AVHSSILCTS KDYGLFYLQQ GNSGSLSILE
2460 2470 2480 2490 2500
QEESGKFEKT LDFNLNLNNP NGSPVSITQA EPESGSSLLC ATSDGMLWNL
2510 2520 2530 2540 2550
SECTPEGEWV VDNIWQKKSR NPKSRTPGTD SSPGLFCMDS WVEPTHLKAR
2560 2570 2580 2590 2600
QCKKIHLGSV TALHVLPGLL VTASEDRDVK LWERPSMQLL GLFRCEGPVS
2610 2620
CLEPWMEPSS PLQLAVGDAQ GNLYFLSWE
Length:2,629
Mass (Da):291,708
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB90C3F72E5D4B6BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JT33A0A0G2JT33_RAT
Telomerase protein component 1
Tep1
2,641Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LPX8F1LPX8_RAT
Telomerase associated protein 1, is...
Tep1 rCG_61172
2,629Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U89282 mRNA Translation: AAB51690.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T32735

NCBI Reference Sequences

More...
RefSeqi
NP_072113.1, NM_022591.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:64523

UCSC genome browser

More...
UCSCi
RGD:3869, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89282 mRNA Translation: AAB51690.1
PIRiT32735
RefSeqiNP_072113.1, NM_022591.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012235

PTM databases

CarbonylDBiO08653
iPTMnetiO08653
PhosphoSitePlusiO08653

Proteomic databases

PaxDbiO08653
PRIDEiO08653

Genome annotation databases

GeneIDi64523
KEGGirno:64523
UCSCiRGD:3869, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7011
RGDi3869, Tep1

Phylogenomic databases

eggNOGiKOG3602, Eukaryota
KOG4155, Eukaryota
InParanoidiO08653
OrthoDBi29963at2759
PhylomeDBiO08653

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O08653

Family and domain databases

Gene3Di2.130.10.10, 6 hits
InterProiView protein in InterPro
IPR025139, DUF4062
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase
IPR008850, TEP1_N
IPR008858, TROVE_dom
IPR037214, TROVE_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF13271, DUF4062, 1 hit
PF05729, NACHT, 1 hit
PF05386, TEP1_N, 4 hits
PF05731, TROVE, 1 hit
PF00400, WD40, 5 hits
SMARTiView protein in SMART
SM00320, WD40, 16 hits
SUPFAMiSSF140864, SSF140864, 1 hit
SSF50978, SSF50978, 4 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50837, NACHT, 1 hit
PS51226, TEP1_N, 4 hits
PS50988, TROVE, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 7 hits
PS50294, WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEP1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08653
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 1, 1997
Last modified: December 2, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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