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Protein

SH3 domain-containing YSC84-like protein 1

Gene

Sh3yl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: MGI
  • regulation of ruffle assembly Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing YSC84-like protein 1
Gene namesi
Name:Sh3yl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1346118 Sh3yl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415611 – 340SH3 domain-containing YSC84-like protein 1Add BLAST340

Proteomic databases

PaxDbiO08641
PeptideAtlasiO08641
PRIDEiO08641

PTM databases

PhosphoSitePlusiO08641

Expressioni

Tissue specificityi

Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle.1 Publication

Developmental stagei

In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases.1 Publication

Gene expression databases

BgeeiENSMUSG00000020669 Expressed in 252 organ(s), highest expression level in cornea
GenevisibleiO08641 MM

Interactioni

Subunit structurei

Interacts with SH3D19.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sh3d19Q91X433EBI-2024519,EBI-2024543

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08641, 2 interactors
STRINGi10090.ENSMUSP00000020997

Structurei

3D structure databases

ProteinModelPortaliO08641
SMRiO08641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 340SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1843 Eukaryota
COG2930 LUCA
GeneTreeiENSGT00510000048137
HOGENOMiHOG000215564
HOVERGENiHBG108487
InParanoidiO08641
KOiK20523
OMAiCTVAVGP
OrthoDBiEOG091G0E6Y
PhylomeDBiO08641
TreeFamiTF331022

Family and domain databases

CDDicd11841 SH3_SH3YL1_like, 1 hit
cd11525 SYLF_SH3YL1_like, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035511 SH3YL1_SH3
IPR033643 SYLF_SH3YL1-like
IPR007461 Ysc84_actin-binding
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF04366 Ysc84, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O08641-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL
60 70 80 90 100
SVIKAGFLVT ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD
110 120 130 140 150
LVIILNYDRA VEAFAKGGNL TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF
160 170 180 190 200
TYCKSRGLFA GISLEGSCLI ERKETNRKFY CQDIRAYDIL FGDVPQPAQA
210 220 230 240 250
EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP SSRPQPAHPP
260 270 280 290 300
VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL
310 320 330 340
NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN
Length:340
Mass (Da):37,028
Last modified:July 1, 1997 - v1
Checksum:i3FE12C0A8530C74E
GO
Isoform 2 (identifier: O08641-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-76: AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK → E

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,320
Checksum:iF3D2AA03ACC883CD
GO
Isoform 3 (identifier: O08641-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-340: AKELPPKPSS...IFPANYVTMN → VLWPGFTSLSVNMRGSVLAQL

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):27,215
Checksum:i9B545B95D3E011ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200A → T in AAH61488 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03433638 – 76AHVIA…LPDGK → E in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_034337233 – 340AKELP…YVTMN → VLWPGFTSLSVNMRGSVLAQ L in isoform 3. CuratedAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85926 mRNA Translation: BAA19679.1
AK141199 mRNA Translation: BAE24582.1
BC010296 mRNA Translation: AAH10296.1
BC058557 mRNA Translation: AAH58557.1
BC061488 mRNA Translation: AAH61488.1
BC110043 mRNA Translation: AAI10044.1
CCDSiCCDS25859.1 [O08641-1]
CCDS79110.1 [O08641-2]
RefSeqiNP_001276409.1, NM_001289480.1 [O08641-2]
NP_038737.1, NM_013709.5 [O08641-1]
UniGeneiMm.218624

Genome annotation databases

EnsembliENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669 [O08641-1]
ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669 [O08641-2]
GeneIDi24057
KEGGimmu:24057
UCSCiuc007ngz.2 mouse [O08641-1]
uc011ylg.2 mouse [O08641-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85926 mRNA Translation: BAA19679.1
AK141199 mRNA Translation: BAE24582.1
BC010296 mRNA Translation: AAH10296.1
BC058557 mRNA Translation: AAH58557.1
BC061488 mRNA Translation: AAH61488.1
BC110043 mRNA Translation: AAI10044.1
CCDSiCCDS25859.1 [O08641-1]
CCDS79110.1 [O08641-2]
RefSeqiNP_001276409.1, NM_001289480.1 [O08641-2]
NP_038737.1, NM_013709.5 [O08641-1]
UniGeneiMm.218624

3D structure databases

ProteinModelPortaliO08641
SMRiO08641
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08641, 2 interactors
STRINGi10090.ENSMUSP00000020997

PTM databases

PhosphoSitePlusiO08641

Proteomic databases

PaxDbiO08641
PeptideAtlasiO08641
PRIDEiO08641

Protocols and materials databases

DNASUi24057
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669 [O08641-1]
ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669 [O08641-2]
GeneIDi24057
KEGGimmu:24057
UCSCiuc007ngz.2 mouse [O08641-1]
uc011ylg.2 mouse [O08641-2]

Organism-specific databases

CTDi26751
MGIiMGI:1346118 Sh3yl1

Phylogenomic databases

eggNOGiKOG1843 Eukaryota
COG2930 LUCA
GeneTreeiENSGT00510000048137
HOGENOMiHOG000215564
HOVERGENiHBG108487
InParanoidiO08641
KOiK20523
OMAiCTVAVGP
OrthoDBiEOG091G0E6Y
PhylomeDBiO08641
TreeFamiTF331022

Miscellaneous databases

PROiPR:O08641
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020669 Expressed in 252 organ(s), highest expression level in cornea
GenevisibleiO08641 MM

Family and domain databases

CDDicd11841 SH3_SH3YL1_like, 1 hit
cd11525 SYLF_SH3YL1_like, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035511 SH3YL1_SH3
IPR033643 SYLF_SH3YL1-like
IPR007461 Ysc84_actin-binding
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF04366 Ysc84, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSH3Y1_MOUSE
AccessioniPrimary (citable) accession number: O08641
Secondary accession number(s): Q6P7V3, Q6PDR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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