UniProtKB - O08615 (OXLA_MUSSP)
L-amino-acid oxidase
Il4i1
Functioni
Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity. Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4+ T-cells into FOXP3+ regulatory T-cells (Treg) and regulates the development and function of B-cells (By similarity).
Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity).
Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2 (By similarity).
By similarityCatalytic activityi
- EC:1.4.3.2By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- EC:1.4.3.25By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
: L-tryptophan degradation via pyruvate pathway Pathwayi
This protein is involved in the pathway L-tryptophan degradation via pyruvate pathway, which is part of Amino-acid degradation.By similarityView all proteins of this organism that are known to be involved in the pathway L-tryptophan degradation via pyruvate pathway and in Amino-acid degradation.
GO - Molecular functioni
- L-amino-acid oxidase activity Source: UniProtKB
- L-phenylalaine oxidase activity Source: RHEA
- oxidoreductase activity Source: GO_Central
- polyamine oxidase activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cellular amino acid catabolic process Source: GO_Central
- L-phenylalanine catabolic process Source: UniProtKB
- negative regulation of T cell activation Source: UniProtKB
- negative regulation of T cell mediated immune response to tumor cell Source: UniProtKB
- negative regulation of T cell proliferation Source: UniProtKB
- positive regulation of regulatory T cell differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of adaptive immune response Source: UniProtKB
- regulation of B cell differentiation Source: UniProtKB
- tryptophan catabolic process Source: UniProtKB
- tryptophan catabolic process to indole-3-acetate Source: UniProtKB
- tyrosine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Adaptive immunity, Immunity |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
UniPathwayi | UPA00332 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Mus spretus (Western Mediterranean mouse) (Algerian mouse) |
Taxonomic identifieri | 10096 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:109552, Il4i1 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- immunological synapse Source: UniProtKB
Other locations
- acrosomal vesicle Source: UniProtKB
- sperm midpiece Source: UniProtKB
Keywords - Cellular componenti
Cytoplasmic vesicle, Lysosome, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099873 | ‹1 – ›46 | L-amino-acid oxidaseAdd BLAST | ›46 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinExpressioni
Inductioni
Family & Domainsi
Sequence similaritiesi
i Sequence
Sequence statusi: Fragment.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 46 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U80211 Genomic DNA Translation: AAB51360.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U80211 Genomic DNA Translation: AAB51360.1 |
3D structure databases
AlphaFoldDBi | O08615 |
SMRi | O08615 |
ModBasei | Search... |
Organism-specific databases
MGIi | MGI:109552, Il4i1 |
Enzyme and pathway databases
UniPathwayi | UPA00332 |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | OXLA_MUSSP | |
Accessioni | O08615Primary (citable) accession number: O08615 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2002 |
Last sequence update: | July 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families