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Protein

Ornithine decarboxylase antizyme 2

Gene

Oaz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338).4 Publications

GO - Molecular functioni

  • ornithine decarboxylase inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Biological processPolyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 2
Short name:
AZ2
Short name:
ODC-Az 2
Alternative name(s):
Seizure-related protein 15
Gene namesi
Name:Oaz2
Synonyms:Sez15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109492 Oaz2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208581 – 189Ornithine decarboxylase antizyme 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO08608
PaxDbiO08608
PRIDEiO08608

PTM databases

iPTMnetiO08608
PhosphoSitePlusiO08608

Expressioni

Gene expression databases

BgeeiENSMUSG00000040652 Expressed in 33 organ(s), highest expression level in lung
CleanExiMM_OAZ2
ExpressionAtlasiO08608 baseline and differential
GenevisibleiO08608 MM

Interactioni

Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:16916800).By similarity1 Publication

Protein-protein interaction databases

IntActiO08608, 1 interactor
STRINGi10090.ENSMUSP00000136914

Structurei

3D structure databases

ProteinModelPortaliO08608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387 Eukaryota
ENOG4112791 LUCA
GeneTreeiENSGT00390000009476
HOVERGENiHBG007857
InParanoidiO08608
KOiK16613
OMAiFICFRKS
OrthoDBiEOG091G0SR0
TreeFamiTF314741

Family and domain databases

Gene3Di3.40.630.60, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029916 ODC-AZ_2
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf
PANTHERiPTHR10279 PTHR10279, 1 hit
PTHR10279:SF6 PTHR10279:SF6, 1 hit
PfamiView protein in Pfam
PF02100 ODC_AZ, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS01337 ODC_AZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket
Note: A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O08608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MINTQDSSIL PLSKCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD
60 70 80 90 100
PSLSALIYKD EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ
110 120 130 140 150
SLFVEIPDGL LADGSKEGLL ALLEFAEEKM KVNYVFICFR KGREDRAPLL
160 170 180
KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP LDQNLSDED
Length:189
Mass (Da):21,025
Last modified:May 30, 2000 - v2
Checksum:i7B8C08843686163B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QNN0J3QNN0_MOUSE
Ornithine decarboxylase antizyme 2
Oaz2
188Annotation score:
J3QJW9J3QJW9_MOUSE
Ornithine decarboxylase antizyme 2
Oaz2
130Annotation score:
J3QPT5J3QPT5_MOUSE
Ornithine decarboxylase antizyme 2
Oaz2
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057298 mRNA Translation: AAD03266.1
D78643 mRNA Translation: BAA19569.1
CCDSiCCDS57683.1 [O08608-1]
RefSeqiNP_035082.1, NM_010952.3 [O08608-1]
UniGeneiMm.116749

Genome annotation databases

EnsembliENSMUST00000153700; ENSMUSP00000136914; ENSMUSG00000040652 [O08608-1]
GeneIDi18247
KEGGimmu:18247
UCSCiuc009qdu.2 mouse [O08608-1]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057298 mRNA Translation: AAD03266.1
D78643 mRNA Translation: BAA19569.1
CCDSiCCDS57683.1 [O08608-1]
RefSeqiNP_035082.1, NM_010952.3 [O08608-1]
UniGeneiMm.116749

3D structure databases

ProteinModelPortaliO08608
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08608, 1 interactor
STRINGi10090.ENSMUSP00000136914

PTM databases

iPTMnetiO08608
PhosphoSitePlusiO08608

Proteomic databases

MaxQBiO08608
PaxDbiO08608
PRIDEiO08608

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000153700; ENSMUSP00000136914; ENSMUSG00000040652 [O08608-1]
GeneIDi18247
KEGGimmu:18247
UCSCiuc009qdu.2 mouse [O08608-1]

Organism-specific databases

CTDi4947
MGIiMGI:109492 Oaz2

Phylogenomic databases

eggNOGiKOG4387 Eukaryota
ENOG4112791 LUCA
GeneTreeiENSGT00390000009476
HOVERGENiHBG007857
InParanoidiO08608
KOiK16613
OMAiFICFRKS
OrthoDBiEOG091G0SR0
TreeFamiTF314741

Enzyme and pathway databases

ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)

Miscellaneous databases

PROiPR:O08608
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040652 Expressed in 33 organ(s), highest expression level in lung
CleanExiMM_OAZ2
ExpressionAtlasiO08608 baseline and differential
GenevisibleiO08608 MM

Family and domain databases

Gene3Di3.40.630.60, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029916 ODC-AZ_2
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf
PANTHERiPTHR10279 PTHR10279, 1 hit
PTHR10279:SF6 PTHR10279:SF6, 1 hit
PfamiView protein in Pfam
PF02100 ODC_AZ, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS01337 ODC_AZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOAZ2_MOUSE
AccessioniPrimary (citable) accession number: O08608
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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