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Protein

Endonuclease G, mitochondrial

Gene

Endog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).By similarity

Miscellaneous

The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.By similarity

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138Proton acceptorPROSITE-ProRule annotation1
Metal bindingi169Magnesium or manganese; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease G, mitochondrial (EC:3.1.30.-)
Short name:
Endo G
Gene namesi
Name:Endog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1261433 Endog

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionBy similarityAdd BLAST44
ChainiPRO_000001991945 – 294Endonuclease G, mitochondrialAdd BLAST250

Proteomic databases

EPDiO08600
PaxDbiO08600
PeptideAtlasiO08600
PRIDEiO08600

PTM databases

iPTMnetiO08600
PhosphoSitePlusiO08600

Expressioni

Gene expression databases

BgeeiENSMUSG00000015337 Expressed in 247 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_ENDOG
ExpressionAtlasiO08600 baseline and differential
GenevisibleiO08600 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO08600, 2 interactors
MINTiO08600
STRINGi10090.ENSMUSP00000015481

Structurei

3D structure databases

ProteinModelPortaliO08600
SMRiO08600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3721 Eukaryota
COG1864 LUCA
GeneTreeiENSGT00530000063772
HOGENOMiHOG000214172
HOVERGENiHBG002851
InParanoidiO08600
KOiK01173
OMAiVPHWVFE
OrthoDBiEOG091G0BHG
PhylomeDBiO08600
TreeFamiTF105386

Family and domain databases

InterProiView protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
PROSITEiView protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALRAGLTL ALGAGLGAAA EHWRRREGKA PGLLGRVPLL PVVAADLPAL
60 70 80 90 100
PGGPAGGTGE LAKYGLPGVA QLRSRESYVL SYDPRTRGAL WVLEQLRPER
110 120 130 140 150
LRGDGDRSAC DFREDDSVHA YHRATNADYR GSGFDRGHLA AAANHRWSQR
160 170 180 190 200
AMDDTFYLSN VAPQVPHLNQ NAWNNLERYS RSLTRTYQNV YVCTGPLFLP
210 220 230 240 250
RTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAAGGQIE LRSYVMPNAP
260 270 280 290
VDETIPLERF LVPIESIERA SGLLFVPNIL ARAGNLKAIT AGSK
Length:294
Mass (Da):32,191
Last modified:July 1, 1997 - v1
Checksum:i9F01FB1BC28B95D3
GO

Sequence cautioni

The sequence CAA67768 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99395 Genomic DNA Translation: CAA67769.1
X99394 mRNA Translation: CAA67768.1 Different initiation.
AB012108 mRNA Translation: BAA28168.1
BC030177 mRNA Translation: AAH30177.1
CCDSiCCDS15872.1
RefSeqiNP_031957.1, NM_007931.1
UniGeneiMm.474473

Genome annotation databases

EnsembliENSMUST00000015481; ENSMUSP00000015481; ENSMUSG00000015337
GeneIDi13804
KEGGimmu:13804
UCSCiuc008jbk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99395 Genomic DNA Translation: CAA67769.1
X99394 mRNA Translation: CAA67768.1 Different initiation.
AB012108 mRNA Translation: BAA28168.1
BC030177 mRNA Translation: AAH30177.1
CCDSiCCDS15872.1
RefSeqiNP_031957.1, NM_007931.1
UniGeneiMm.474473

3D structure databases

ProteinModelPortaliO08600
SMRiO08600
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08600, 2 interactors
MINTiO08600
STRINGi10090.ENSMUSP00000015481

PTM databases

iPTMnetiO08600
PhosphoSitePlusiO08600

Proteomic databases

EPDiO08600
PaxDbiO08600
PeptideAtlasiO08600
PRIDEiO08600

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015481; ENSMUSP00000015481; ENSMUSG00000015337
GeneIDi13804
KEGGimmu:13804
UCSCiuc008jbk.1 mouse

Organism-specific databases

CTDi2021
MGIiMGI:1261433 Endog

Phylogenomic databases

eggNOGiKOG3721 Eukaryota
COG1864 LUCA
GeneTreeiENSGT00530000063772
HOGENOMiHOG000214172
HOVERGENiHBG002851
InParanoidiO08600
KOiK01173
OMAiVPHWVFE
OrthoDBiEOG091G0BHG
PhylomeDBiO08600
TreeFamiTF105386

Miscellaneous databases

ChiTaRSiEndog mouse
PROiPR:O08600
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015337 Expressed in 247 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_ENDOG
ExpressionAtlasiO08600 baseline and differential
GenevisibleiO08600 MM

Family and domain databases

InterProiView protein in InterPro
IPR018524 DNA/RNA_endonuclease_AS
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR020821 Extracellular_endonuc_su_A
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
PROSITEiView protein in PROSITE
PS01070 NUCLEASE_NON_SPEC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUCG_MOUSE
AccessioniPrimary (citable) accession number: O08600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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