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Protein

Syntaxin-binding protein 1

Gene

Stxbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 1
Alternative name(s):
Protein unc-18 homolog 1
Short name:
Unc18-1
Protein unc-18 homolog A
Short name:
Unc-18A
Gene namesi
Name:Stxbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107363 Stxbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062781 – 594Syntaxin-binding protein 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei476PhosphoserineBy similarity1
Modified residuei509PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei593PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08599
MaxQBiO08599
PaxDbiO08599
PeptideAtlasiO08599
PRIDEiO08599

PTM databases

iPTMnetiO08599
PhosphoSitePlusiO08599
SwissPalmiO08599

Expressioni

Gene expression databases

BgeeiENSMUSG00000026797 Expressed in 261 organ(s), highest expression level in retina
CleanExiMM_STXBP1
ExpressionAtlasiO08599 baseline and differential
GenevisibleiO08599 MM

Interactioni

Subunit structurei

Binds SYTL4. Interacts with STX1A.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Grm4P314232EBI-15809216,EBI-7974891From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203564, 12 interactors
DIPiDIP-31951N
IntActiO08599, 20 interactors
MINTiO08599
STRINGi10090.ENSMUSP00000089051

Structurei

3D structure databases

ProteinModelPortaliO08599
SMRiO08599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1300 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00390000005206
HOGENOMiHOG000232146
HOVERGENiHBG052710
InParanoidiO08599
KOiK15292
OMAiMHMREAI
OrthoDBiEOG091G0WUI
PhylomeDBiO08599
TreeFamiTF313242

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O08599-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI
60 70 80 90 100
MTEGITIVED INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR
110 120 130 140 150
AAHVFFTDSC PDALFNELVK SRAAKVIKTL TEINIAFLPY ESQVYSLDSA
160 170 180 190 200
DSFQSFYSPH KAQMKNPILE RLAEQIATLC ATLKEYPAVR YRGEYKDNAL
210 220 230 240 250
LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS SPVLHELTFQ
260 270 280 290 300
AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS
310 320 330 340 350
QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL
360 370 380 390 400
AEDCMKHYQG TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS
410 420 430 440 450
TYDKIRIILL YIFLKNGITE ENLNKLIQHA QIPPEDSEII TNMAHLGVPI
460 470 480 490 500
VTDSTLRRRS KPERKERISE QTYQLSRWTP IIKDIMEDTI EDKLDTKHYP
510 520 530 540 550
YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF ILGGVSLNEM
560 570 580 590
RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS
Length:594
Mass (Da):67,569
Last modified:June 7, 2004 - v2
Checksum:i2DD0715F875CE0F3
GO
Isoform 2 (identifier: O08599-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-594: QKLLDTLKKLNKTDEEISS → TKFLMDLRHPDFRESSRVSFEDQAPTME

Show »
Length:603
Mass (Da):68,736
Checksum:i73D8337768259493
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHJ4A0A140LHJ4_MOUSE
Syntaxin-binding protein 1
Stxbp1
100Annotation score:

Sequence cautioni

The sequence CAM20726 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101A → R in BAA19479 (PubMed:8824310).Curated1
Sequence conflicti367R → H in BAA32486 (PubMed:9705297).Curated1
Sequence conflicti537L → F in BAA19479 (PubMed:8824310).Curated1
Sequence conflicti561G → A in BAA19479 (PubMed:8824310).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti216D → N in strain: DBA/2J. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010496576 – 594QKLLD…EEISS → TKFLMDLRHPDFRESSRVSF EDQAPTME in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45903 mRNA Translation: BAA19479.1
AB012697 Genomic DNA Translation: BAA32486.1
AF326545 mRNA Translation: AAL37391.1
AF326563 mRNA Translation: AAL37409.1
AL845471 Genomic DNA Translation: CAM20726.1 Sequence problems.
AL845471 Genomic DNA Translation: CAM20727.1
AL845471 Genomic DNA Translation: CAM20728.1
BC031728 mRNA Translation: AAH31728.1
CCDSiCCDS15933.1 [O08599-1]
CCDS50572.1 [O08599-2]
RefSeqiNP_001107041.1, NM_001113569.1 [O08599-2]
NP_033321.2, NM_009295.2 [O08599-1]
UniGeneiMm.278865

Genome annotation databases

EnsembliENSMUST00000050000; ENSMUSP00000052440; ENSMUSG00000026797 [O08599-1]
ENSMUST00000077458; ENSMUSP00000089051; ENSMUSG00000026797 [O08599-2]
GeneIDi20910
KEGGimmu:20910
UCSCiuc008jha.2 mouse [O08599-1]
uc008jhb.2 mouse [O08599-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45903 mRNA Translation: BAA19479.1
AB012697 Genomic DNA Translation: BAA32486.1
AF326545 mRNA Translation: AAL37391.1
AF326563 mRNA Translation: AAL37409.1
AL845471 Genomic DNA Translation: CAM20726.1 Sequence problems.
AL845471 Genomic DNA Translation: CAM20727.1
AL845471 Genomic DNA Translation: CAM20728.1
BC031728 mRNA Translation: AAH31728.1
CCDSiCCDS15933.1 [O08599-1]
CCDS50572.1 [O08599-2]
RefSeqiNP_001107041.1, NM_001113569.1 [O08599-2]
NP_033321.2, NM_009295.2 [O08599-1]
UniGeneiMm.278865

3D structure databases

ProteinModelPortaliO08599
SMRiO08599
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203564, 12 interactors
DIPiDIP-31951N
IntActiO08599, 20 interactors
MINTiO08599
STRINGi10090.ENSMUSP00000089051

PTM databases

iPTMnetiO08599
PhosphoSitePlusiO08599
SwissPalmiO08599

Proteomic databases

EPDiO08599
MaxQBiO08599
PaxDbiO08599
PeptideAtlasiO08599
PRIDEiO08599

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050000; ENSMUSP00000052440; ENSMUSG00000026797 [O08599-1]
ENSMUST00000077458; ENSMUSP00000089051; ENSMUSG00000026797 [O08599-2]
GeneIDi20910
KEGGimmu:20910
UCSCiuc008jha.2 mouse [O08599-1]
uc008jhb.2 mouse [O08599-2]

Organism-specific databases

CTDi6812
MGIiMGI:107363 Stxbp1

Phylogenomic databases

eggNOGiKOG1300 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00390000005206
HOGENOMiHOG000232146
HOVERGENiHBG052710
InParanoidiO08599
KOiK15292
OMAiMHMREAI
OrthoDBiEOG091G0WUI
PhylomeDBiO08599
TreeFamiTF313242

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

ChiTaRSiStxbp1 mouse
PROiPR:O08599
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026797 Expressed in 261 organ(s), highest expression level in retina
CleanExiMM_STXBP1
ExpressionAtlasiO08599 baseline and differential
GenevisibleiO08599 MM

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB1_MOUSE
AccessioniPrimary (citable) accession number: O08599
Secondary accession number(s): A2ARS2
, A2ARS3, A2ARS4, Q5WAC6, Q8VD51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2004
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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