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Protein

Krueppel-like factor 6

Gene

Klf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri230 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 6
Alternative name(s):
Core promoter element-binding protein
Gene namesi
Name:Klf6
Synonyms:Copeb, Cpbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346318 Klf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471721 – 283Krueppel-like factor 6Add BLAST283

Proteomic databases

EPDiO08584
MaxQBiO08584
PaxDbiO08584
PRIDEiO08584

PTM databases

iPTMnetiO08584
PhosphoSitePlusiO08584

Expressioni

Tissue specificityi

Highly expressed in placenta.

Developmental stagei

Expression is lower in total embryos and in adult tissues.

Gene expression databases

CleanExiMM_KLF6

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000080

Structurei

3D structure databases

ProteinModelPortaliO08584
SMRiO08584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri230 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOVERGENiHBG000836
InParanoidiO08584
PhylomeDBiO08584

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV
60 70 80 90 100
SASEIKFDSQ EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE
110 120 130 140 150
TNSLNSDVSS ESSDSSEELS PTTKFTSDPI GEVLVNSGNL SSSVISTPPS
160 170 180 190 200
SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS GKSGDKGNGD ASPDGRRRVH
210 220 230 240 250
RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR FARSDELTRH
260 270 280
FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
Length:283
Mass (Da):31,877
Last modified:May 30, 2000 - v3
Checksum:i8ACF664A9C6697FC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BPQ2Q8BPQ2_MOUSE
Krueppel-like factor 6
Klf6 mCG_1722
318Annotation score:
A0A1Y7VLA9A0A1Y7VLA9_MOUSE
Krueppel-like factor 6
Klf6
86Annotation score:

Sequence cautioni

The sequence AAC99478 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072403 mRNA Translation: AAC99478.1 Different initiation.
AY027436 mRNA Translation: AAK11733.1
UniGeneiMm.275036

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072403 mRNA Translation: AAC99478.1 Different initiation.
AY027436 mRNA Translation: AAK11733.1
UniGeneiMm.275036

3D structure databases

ProteinModelPortaliO08584
SMRiO08584
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000080

PTM databases

iPTMnetiO08584
PhosphoSitePlusiO08584

Proteomic databases

EPDiO08584
MaxQBiO08584
PaxDbiO08584
PRIDEiO08584

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346318 Klf6

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOVERGENiHBG000836
InParanoidiO08584
PhylomeDBiO08584

Miscellaneous databases

ChiTaRSiKlf6 mouse
PROiPR:O08584
SOURCEiSearch...

Gene expression databases

CleanExiMM_KLF6

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF6_MOUSE
AccessioniPrimary (citable) accession number: O08584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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