Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein 1

Gene

Gtpbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 174GTPSequence analysis8
Nucleotide bindingi252 – 256GTPSequence analysis5
Nucleotide bindingi308 – 311GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • translation elongation factor activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Short name:
G-protein 1
Short name:
GP-1
Short name:
GP1
Gene namesi
Name:Gtpbp1
Synonyms:Gtpbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109443 Gtpbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian ratio, develop normally and are fertile. They exhibit increased stability of some mRNA species.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224701 – 668GTP-binding protein 1Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei69PhosphoserineBy similarity1
Modified residuei580PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08582
MaxQBiO08582
PaxDbiO08582
PeptideAtlasiO08582
PRIDEiO08582

PTM databases

iPTMnetiO08582
PhosphoSitePlusiO08582

Expressioni

Tissue specificityi

Detected in some neurons in the brain cortex. Detected in small arteries, dendritic cells and macrophages in the thymus. Detected in lung bronchi, in bronchial epithelial cells and in bronchial smooth muscle cells. Detected in smooth muscle cells in a broad range of organs (at protein level). Expressed in brain, thymus, lung, and kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000042535 Expressed in 277 organ(s), highest expression level in retina
CleanExiMM_GTPBP1
GenevisibleiO08582 MM

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).By similarity

Protein-protein interaction databases

IntActiO08582, 1 interactor
MINTiO08582
STRINGi10090.ENSMUSP00000043575

Structurei

3D structure databases

ProteinModelPortaliO08582
SMRiO08582
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08582

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 389tr-type GPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 174G1PROSITE-ProRule annotation8
Regioni206 – 210G2PROSITE-ProRule annotation5
Regioni252 – 255G3PROSITE-ProRule annotation4
Regioni308 – 311G4PROSITE-ProRule annotation4
Regioni366 – 368G5PROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 36Poly-Ala9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0463 Eukaryota
COG5258 LUCA
GeneTreeiENSGT00730000110829
HOGENOMiHOG000176635
HOVERGENiHBG004471
InParanoidiO08582
OMAiYLRKGMV
OrthoDBiEOG091G06LY
PhylomeDBiO08582
TreeFamiTF350446

Family and domain databases

CDDicd04165 GTPBP1_like, 1 hit
InterProiView protein in InterPro
IPR039263 GTPB1
IPR035531 GTPBP1-like
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PANTHERiPTHR43721:SF14 PTHR43721:SF14, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O08582-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAERSRSPV DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG
60 70 80 90 100
EALNGEPELD LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG
110 120 130 140 150
SDGTEYGLSE ADMEASYATV KSMAEQIEAD VILLRERQEA GGRVRDYLVR
160 170 180 190 200
KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL THGELDNGRG FARQKLFRHK
210 220 230 240 250
HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI CEKSSKVITF
260 270 280 290 300
IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
310 320 330 340 350
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT
360 370 380 390 400
ASNFSSERMC PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID
410 420 430 440 450
DTYSVPGVGT VVSGTTLRGL IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM
460 470 480 490 500
PVKEVRGGQT ASFALKKIKR SSIRKGMVMV SPRLNPQASW EFEAEILVLH
510 520 530 540 550
HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV HFRFIKTPEY
560 570 580 590 600
LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLS
610 620 630 640 650
KREEGGPCGV PAAGGPPTGD EASSLGTAQA ASTSGLQPQP KPSSGGRRRG
660
GQRHKVKSGA CVTPASGC
Length:668
Mass (Da):72,301
Last modified:September 5, 2006 - v2
Checksum:iE77C2148D6B237F8
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VI47A0A2R8VI47_MOUSE
GTP-binding protein 1
Gtpbp1
174Annotation score:
A0A2R8VKJ2A0A2R8VKJ2_MOUSE
GTP-binding protein 1
Gtpbp1
137Annotation score:
A0A2R8VHC2A0A2R8VHC2_MOUSE
GTP-binding protein 1
Gtpbp1
201Annotation score:
A0A2R8W725A0A2R8W725_MOUSE
GTP-binding protein 1
Gtpbp1
196Annotation score:
A0A2R8W6Z1A0A2R8W6Z1_MOUSE
GTP-binding protein 1
Gtpbp1
145Annotation score:
A0A2R8W6M4A0A2R8W6M4_MOUSE
GTP-binding protein 1
Gtpbp1
80Annotation score:

Sequence cautioni

The sequence AAB51274 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB23409 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE28091 differs from that shown. Reason: Frameshift at position 631.Curated
The sequence BAE29280 differs from that shown. Reason: Frameshift at position 666.Curated
The sequence BAE29365 differs from that shown. Reason: Frameshift at position 666.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121K → E in BAE28091 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004612 mRNA Translation: BAB23409.1 Different initiation.
AK147717 mRNA Translation: BAE28091.1 Frameshift.
AK150068 mRNA Translation: BAE29280.1 Frameshift.
AK150185 mRNA Translation: BAE29365.1 Frameshift.
AK170091 mRNA Translation: BAE41557.1
BC046228 mRNA Translation: AAH46228.1
U87965 mRNA Translation: AAB51274.1 Different initiation.
CCDSiCCDS27648.1
PIRiJC5292
RefSeqiNP_038846.2, NM_013818.2
UniGeneiMm.19080

Genome annotation databases

EnsembliENSMUST00000046463; ENSMUSP00000043575; ENSMUSG00000042535
GeneIDi14904
KEGGimmu:14904
UCSCiuc007wuf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004612 mRNA Translation: BAB23409.1 Different initiation.
AK147717 mRNA Translation: BAE28091.1 Frameshift.
AK150068 mRNA Translation: BAE29280.1 Frameshift.
AK150185 mRNA Translation: BAE29365.1 Frameshift.
AK170091 mRNA Translation: BAE41557.1
BC046228 mRNA Translation: AAH46228.1
U87965 mRNA Translation: AAB51274.1 Different initiation.
CCDSiCCDS27648.1
PIRiJC5292
RefSeqiNP_038846.2, NM_013818.2
UniGeneiMm.19080

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJ2X-ray2.71P/Q246-253[»]
1KJ3X-ray2.30P/Q246-253[»]
ProteinModelPortaliO08582
SMRiO08582
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08582, 1 interactor
MINTiO08582
STRINGi10090.ENSMUSP00000043575

PTM databases

iPTMnetiO08582
PhosphoSitePlusiO08582

Proteomic databases

EPDiO08582
MaxQBiO08582
PaxDbiO08582
PeptideAtlasiO08582
PRIDEiO08582

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046463; ENSMUSP00000043575; ENSMUSG00000042535
GeneIDi14904
KEGGimmu:14904
UCSCiuc007wuf.1 mouse

Organism-specific databases

CTDi9567
MGIiMGI:109443 Gtpbp1

Phylogenomic databases

eggNOGiKOG0463 Eukaryota
COG5258 LUCA
GeneTreeiENSGT00730000110829
HOGENOMiHOG000176635
HOVERGENiHBG004471
InParanoidiO08582
OMAiYLRKGMV
OrthoDBiEOG091G06LY
PhylomeDBiO08582
TreeFamiTF350446

Miscellaneous databases

ChiTaRSiGtpbp1 mouse
EvolutionaryTraceiO08582
PROiPR:O08582
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042535 Expressed in 277 organ(s), highest expression level in retina
CleanExiMM_GTPBP1
GenevisibleiO08582 MM

Family and domain databases

CDDicd04165 GTPBP1_like, 1 hit
InterProiView protein in InterPro
IPR039263 GTPB1
IPR035531 GTPBP1-like
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PANTHERiPTHR43721:SF14 PTHR43721:SF14, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB1_MOUSE
AccessioniPrimary (citable) accession number: O08582
Secondary accession number(s): Q3UD96
, Q3UGW6, Q545R1, Q80ZY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again