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Protein

Emerin

Gene

Emd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-4419969 Depolymerisation of the Nuclear Lamina

Names & Taxonomyi

Protein namesi
Recommended name:
Emerin
Gene namesi
Name:Emd
Synonyms:Sta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:108117 Emd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061411 – 259EmerinAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei29PhosphoserineBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei161PhosphotyrosineCombined sources1
Modified residuei171PhosphoserineBy similarity1
Modified residuei174PhosphoserineBy similarity1
Modified residuei176PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO08579
PaxDbiO08579
PeptideAtlasiO08579
PRIDEiO08579
TopDownProteomicsiO08579

PTM databases

iPTMnetiO08579
PhosphoSitePlusiO08579

Miscellaneous databases

PMAP-CutDBiO08579

Expressioni

Tissue specificityi

Detected in embryonic fibroblasts, skeletal muscle, heart muscle and tongue epithelium (at protein level). Widely expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000001964 Expressed in 263 organ(s), highest expression level in thymus
CleanExiMM_EMD
ExpressionAtlasiO08579 baseline and differential
GenevisibleiO08579 MM

Interactioni

Subunit structurei

Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the inner nuclear membrane. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin (By similarity). Interacts with SUN1 and SUN2. Interacts with TMEM201.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199436, 4 interactors
IntActiO08579, 5 interactors
MINTiO08579
STRINGi10090.ENSMUSP00000002029

Structurei

3D structure databases

ProteinModelPortaliO08579
SMRiO08579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 45LEMPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 223Interaction with F-actinBy similarityAdd BLAST178
Regioni168 – 187Interaction with CTNNB1By similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 59Poly-Ser7
Compositional biasi186 – 200Poly-SerAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ10 Eukaryota
ENOG410ZEWX LUCA
GeneTreeiENSGT00390000002034
HOGENOMiHOG000081509
HOVERGENiHBG001099
InParanoidiO08579
KOiK12569
OMAiHYRPVSN
OrthoDBiEOG091G0M7U
PhylomeDBiO08579
TreeFamiTF337236

Family and domain databases

CDDicd12939 LEM_emerin, 1 hit
Gene3Di1.10.720.40, 1 hit
InterProiView protein in InterPro
IPR035004 Emerin
IPR011015 LEM/LEM-like_dom_sf
IPR003887 LEM_dom
IPR034989 LEM_emerin
PANTHERiPTHR15171 PTHR15171, 1 hit
PfamiView protein in Pfam
PF03020 LEM, 1 hit
SMARTiView protein in SMART
SM00540 LEM, 1 hit
SUPFAMiSSF63451 SSF63451, 1 hit
PROSITEiView protein in PROSITE
PS50954 LEM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O08579-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDYAVLSDT ELAAVLRQYN IPHGPIVGST RKLYEKKIFE YETQRRRLLP
60 70 80 90 100
PNSSSSSFSY QFSDLDSAAV DSDMYDLPKK EDALLYQSKD YNDDYYEESY
110 120 130 140 150
LTTKTYGEPE SVGMSKSFRQ PGTSLVDADT FHHQVRDDIF SSLEEEGKDR
160 170 180 190 200
ERLIYGQDSA YQSIAHYRPI SNVSRSSLGL SYYPTSSTSS VSSSSSSPSS
210 220 230 240 250
WLTRRAIRPE KQAPAAALGQ DRQVPLWGQL LLFLVFAAFL LFVYYSIQAE

EGNPFWMDP
Length:259
Mass (Da):29,436
Last modified:July 1, 1997 - v1
Checksum:i645B021541063502
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFS0D6RFS0_MOUSE
Emerin
Emd
65Annotation score:
I7HJS1I7HJS1_MOUSE
Emerin
Emd RP23-436K3.2-005
223Annotation score:
Q3THM8Q3THM8_MOUSE
Emerin
Emd RP23-436K3.2-002
158Annotation score:
B7FAU5B7FAU5_MOUSE
Emerin
Emd RP23-436K3.2-004
170Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96Y → C in BAE39870 (PubMed:16141072).Curated1
Sequence conflicti254P → H in BAE39870 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79753 Genomic DNA Translation: AAB51239.1
U73902 mRNA Translation: AAD00238.1
AK146361 mRNA Translation: BAE27112.1
AK167852 mRNA Translation: BAE39870.1
CH466650 Genomic DNA Translation: EDL29837.1
BC132131 mRNA Translation: AAI32132.1
BC132133 mRNA Translation: AAI32134.1
CCDSiCCDS30222.1
RefSeqiNP_031953.1, NM_007927.3
UniGeneiMm.18892

Genome annotation databases

EnsembliENSMUST00000002029; ENSMUSP00000002029; ENSMUSG00000001964
GeneIDi13726
KEGGimmu:13726
UCSCiuc009toa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79753 Genomic DNA Translation: AAB51239.1
U73902 mRNA Translation: AAD00238.1
AK146361 mRNA Translation: BAE27112.1
AK167852 mRNA Translation: BAE39870.1
CH466650 Genomic DNA Translation: EDL29837.1
BC132131 mRNA Translation: AAI32132.1
BC132133 mRNA Translation: AAI32134.1
CCDSiCCDS30222.1
RefSeqiNP_031953.1, NM_007927.3
UniGeneiMm.18892

3D structure databases

ProteinModelPortaliO08579
SMRiO08579
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199436, 4 interactors
IntActiO08579, 5 interactors
MINTiO08579
STRINGi10090.ENSMUSP00000002029

PTM databases

iPTMnetiO08579
PhosphoSitePlusiO08579

Proteomic databases

EPDiO08579
PaxDbiO08579
PeptideAtlasiO08579
PRIDEiO08579
TopDownProteomicsiO08579

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002029; ENSMUSP00000002029; ENSMUSG00000001964
GeneIDi13726
KEGGimmu:13726
UCSCiuc009toa.2 mouse

Organism-specific databases

CTDi2010
MGIiMGI:108117 Emd

Phylogenomic databases

eggNOGiENOG410IJ10 Eukaryota
ENOG410ZEWX LUCA
GeneTreeiENSGT00390000002034
HOGENOMiHOG000081509
HOVERGENiHBG001099
InParanoidiO08579
KOiK12569
OMAiHYRPVSN
OrthoDBiEOG091G0M7U
PhylomeDBiO08579
TreeFamiTF337236

Enzyme and pathway databases

ReactomeiR-MMU-4419969 Depolymerisation of the Nuclear Lamina

Miscellaneous databases

ChiTaRSiEmd mouse
PMAP-CutDBiO08579
PROiPR:O08579
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001964 Expressed in 263 organ(s), highest expression level in thymus
CleanExiMM_EMD
ExpressionAtlasiO08579 baseline and differential
GenevisibleiO08579 MM

Family and domain databases

CDDicd12939 LEM_emerin, 1 hit
Gene3Di1.10.720.40, 1 hit
InterProiView protein in InterPro
IPR035004 Emerin
IPR011015 LEM/LEM-like_dom_sf
IPR003887 LEM_dom
IPR034989 LEM_emerin
PANTHERiPTHR15171 PTHR15171, 1 hit
PfamiView protein in Pfam
PF03020 LEM, 1 hit
SMARTiView protein in SMART
SM00540 LEM, 1 hit
SUPFAMiSSF63451 SSF63451, 1 hit
PROSITEiView protein in PROSITE
PS50954 LEM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMD_MOUSE
AccessioniPrimary (citable) accession number: O08579
Secondary accession number(s): Q3TIH6, Q3UJP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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