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Protein

RUN domain-containing protein 3A

Gene

Rundc3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an effector of RAP2A in neuronal cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RUN domain-containing protein 3A
Alternative name(s):
Rap2-interacting protein 8
Short name:
RPIP-8
Gene namesi
Name:Rundc3a
Synonyms:Rap2ip, Rpip8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1858752 Rundc3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241561 – 446RUN domain-containing protein 3AAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215PhosphothreonineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO08576
PaxDbiO08576
PeptideAtlasiO08576
PRIDEiO08576

PTM databases

iPTMnetiO08576
PhosphoSitePlusiO08576
SwissPalmiO08576

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000006575 Expressed in 183 organ(s), highest expression level in cerebellum
CleanExiMM_RUNDC3A
GenevisibleiO08576 MM

Interactioni

Subunit structurei

Interacts with the GTP-bound form of RAP2A.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006750

Structurei

3D structure databases

ProteinModelPortaliO08576
SMRiO08576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 189RUNPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 298Interaction with RAP2A1 PublicationAdd BLAST298

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili267 – 322Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the RUNDC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4381 Eukaryota
ENOG410XRAX LUCA
GeneTreeiENSGT00550000074558
HOGENOMiHOG000143407
HOVERGENiHBG052747
InParanoidiO08576
OMAiTRDEEPW
OrthoDBiEOG091G06Y5
PhylomeDBiO08576
TreeFamiTF323904

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O08576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASFVQTTM ALGLPSKKAS SRNVIVERRN LITVCRFSVK TLLEKYTAEP
60 70 80 90 100
IDDSSEEFVN FAAILEQILS HRFKACAPAG PASWFSSDGQ RGFWDYIRLA
110 120 130 140 150
CSKVPNNCVS SIENMENIST ARAKGRAWIR VALMEKRMSE YITTALRDNR
160 170 180 190 200
TTRRFYDSGA IMLREEATVL TGMLIGLSAI DFSFCLKGEV LDGKTPVVID
210 220 230 240 250
YTPYLKFTQS YDYLTDEEER HSAESSTSED NSPEHPYLPL VTDEDSWYNK
260 270 280 290 300
WHKMEQKFRI VYAQKGYLEE LVRLRESQLK DLEAENRRLQ LQLEEAAAQN
310 320 330 340 350
QREKRELEGV ILELQEQLTG LIPGDHAPLA QGSKELTTSL VNQWPSLSTL
360 370 380 390 400
HRPEGASNSK LYRRHSFMST EPLSAEASLS SDSQRLGEAK RDEEPWGPIG
410 420 430 440
KDPTPSMLGL CGSLASIPSC KSLASFKSNE CLVSDSPEGS PALSPS
Length:446
Mass (Da):50,018
Last modified:July 1, 1997 - v1
Checksum:i5D9D73127A216483
GO
Isoform 2 (identifier: O08576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-79: Missing.
     401-405: KDPTP → SSEPN
     406-446: Missing.

Show »
Length:400
Mass (Da):45,540
Checksum:i59A34711FCEA1F71
GO
Isoform 3 (identifier: O08576-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-405: KDPTP → SSEPN
     406-446: Missing.

Show »
Length:405
Mass (Da):45,954
Checksum:i286777727CD2908E
GO
Isoform 4 (identifier: O08576-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-318: L → LPDPPPPPR
     401-405: KDPTP → SSEPN
     406-446: Missing.

Show »
Length:413
Mass (Da):46,808
Checksum:i0E7062746540D539
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03215775 – 79Missing in isoform 2. Curated5
Alternative sequenceiVSP_032158318L → LPDPPPPPR in isoform 4. 1 Publication1
Alternative sequenceiVSP_032159401 – 405KDPTP → SSEPN in isoform 2, isoform 3 and isoform 4. 1 Publication5
Alternative sequenceiVSP_032160406 – 446Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73941 mRNA Translation: AAB51123.1
AL596258 Genomic DNA No translation available.
BC046319 mRNA Translation: AAH46319.1
CCDSiCCDS25497.1 [O08576-1]
CCDS56812.1 [O08576-4]
RefSeqiNP_001239276.1, NM_001252347.1 [O08576-4]
NP_058039.1, NM_016759.4 [O08576-1]
XP_006533756.1, XM_006533693.2 [O08576-3]
XP_006533757.1, XM_006533694.2 [O08576-2]
UniGeneiMm.2560

Genome annotation databases

EnsembliENSMUST00000006750; ENSMUSP00000006750; ENSMUSG00000006575 [O08576-1]
ENSMUST00000107102; ENSMUSP00000102719; ENSMUSG00000006575 [O08576-3]
ENSMUST00000107103; ENSMUSP00000102720; ENSMUSG00000006575 [O08576-2]
ENSMUST00000107105; ENSMUSP00000102722; ENSMUSG00000006575 [O08576-4]
GeneIDi51799
KEGGimmu:51799
UCSCiuc007lrq.3 mouse [O08576-4]
uc007lrr.3 mouse [O08576-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73941 mRNA Translation: AAB51123.1
AL596258 Genomic DNA No translation available.
BC046319 mRNA Translation: AAH46319.1
CCDSiCCDS25497.1 [O08576-1]
CCDS56812.1 [O08576-4]
RefSeqiNP_001239276.1, NM_001252347.1 [O08576-4]
NP_058039.1, NM_016759.4 [O08576-1]
XP_006533756.1, XM_006533693.2 [O08576-3]
XP_006533757.1, XM_006533694.2 [O08576-2]
UniGeneiMm.2560

3D structure databases

ProteinModelPortaliO08576
SMRiO08576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006750

PTM databases

iPTMnetiO08576
PhosphoSitePlusiO08576
SwissPalmiO08576

Proteomic databases

MaxQBiO08576
PaxDbiO08576
PeptideAtlasiO08576
PRIDEiO08576

Protocols and materials databases

DNASUi51799
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006750; ENSMUSP00000006750; ENSMUSG00000006575 [O08576-1]
ENSMUST00000107102; ENSMUSP00000102719; ENSMUSG00000006575 [O08576-3]
ENSMUST00000107103; ENSMUSP00000102720; ENSMUSG00000006575 [O08576-2]
ENSMUST00000107105; ENSMUSP00000102722; ENSMUSG00000006575 [O08576-4]
GeneIDi51799
KEGGimmu:51799
UCSCiuc007lrq.3 mouse [O08576-4]
uc007lrr.3 mouse [O08576-1]

Organism-specific databases

CTDi10900
MGIiMGI:1858752 Rundc3a

Phylogenomic databases

eggNOGiKOG4381 Eukaryota
ENOG410XRAX LUCA
GeneTreeiENSGT00550000074558
HOGENOMiHOG000143407
HOVERGENiHBG052747
InParanoidiO08576
OMAiTRDEEPW
OrthoDBiEOG091G06Y5
PhylomeDBiO08576
TreeFamiTF323904

Miscellaneous databases

ChiTaRSiRundc3a mouse
PROiPR:O08576
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006575 Expressed in 183 organ(s), highest expression level in cerebellum
CleanExiMM_RUNDC3A
GenevisibleiO08576 MM

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRUN3A_MOUSE
AccessioniPrimary (citable) accession number: O08576
Secondary accession number(s): A2A693, A2A694, Q80Y95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 1, 1997
Last modified: October 10, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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