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Protein

Histone-lysine N-methyltransferase 2B

Gene

Kmt2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.By similarity1 Publication

Caution

The human ortholog, KMT2B/MLL4, was first named MLL2 (see AC Q9UMN6). Thus, mouse Kmt2b/Mll4 is also often referred to as Mll2 and vice versa in the literature.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2583S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei2585S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei2627S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2653ZincBy similarity1
Metal bindingi2701ZincBy similarity1
Binding sitei2702S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi2703ZincBy similarity1
Metal bindingi2708ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi37 – 44A.T hook 18
DNA bindingi110 – 117A.T hook 28
DNA bindingi357 – 365A.T hook 39
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri964 – 1011CXXC-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1207 – 1258PHD-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri1255 – 1309PHD-type 2PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri1341 – 1402PHD-type 3PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1584 – 1624C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1645 – 1692PHD-type 4PROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase 2B (EC:2.1.1.43)
Short name:
Lysine N-methyltransferase 2B
Alternative name(s):
Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog
Trithorax homolog 2
WW domain-binding protein 7
Short name:
WBP-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kmt2b
Synonyms:Mll2, Trx2, Wbp7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109565 Kmt2b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Females are infertile due to anovulation and follicle loss. Oocytes show reduced H3K4me3 but not H3K4me1, abnormal expression of pro-apoptotic genes and Iap elements (which may contribute to oocyte death and, ultimately, follicle loss) and fail to establish transcriptional repression.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001248822 – 2713Histone-lysine N-methyltransferase 2BAdd BLAST2712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki810Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei826PhosphoserineBy similarity1
Modified residuei849PhosphoserineBy similarity1
Modified residuei866PhosphoserineBy similarity1
Modified residuei941PhosphoserineBy similarity1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1101PhosphoserineCombined sources1
Cross-linki1142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1926PhosphoserineBy similarity1
Modified residuei1932PhosphoserineBy similarity1
Modified residuei2064PhosphothreonineCombined sources1
Modified residuei2079PhosphothreonineBy similarity1
Modified residuei2286PhosphoserineBy similarity1
Modified residuei2346PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O08550

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O08550

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O08550

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08550

PRoteomics IDEntifications database

More...
PRIDEi
O08550

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08550

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08550

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000006307 Expressed in 245 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
MM_WBP7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O08550 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O08550 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the menin-associated histone methyltransferase complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, DPY30, MEN1; the complex interacts with POLR2A and POLR2B via MEN1. Interacts with NFE2. Interacts with KDM6B.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
217461, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O08550

Protein interaction database and analysis system

More...
IntActi
O08550, 1 interactor

Molecular INTeraction database

More...
MINTi
O08550

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000103789

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O08550

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08550

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1733 – 1789FYR N-terminalPROSITE-ProRule annotationAdd BLAST57
Domaini2409 – 2490FYR C-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini2573 – 2689SETPROSITE-ProRule annotationAdd BLAST117
Domaini2697 – 2713Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2650 – 2651S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 106Gly-richAdd BLAST101
Compositional biasi272 – 300Gly-richAdd BLAST29
Compositional biasi347 – 410Glu-richAdd BLAST64
Compositional biasi414 – 776Pro-richAdd BLAST363
Compositional biasi1814 – 2296Pro-richAdd BLAST483

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri964 – 1011CXXC-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1207 – 1258PHD-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri1255 – 1309PHD-type 2PROSITE-ProRule annotationAdd BLAST55
Zinc fingeri1341 – 1402PHD-type 3PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1584 – 1624C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1645 – 1692PHD-type 4PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1084 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161496

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015326

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100043

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08550

KEGG Orthology (KO)

More...
KOi
K14959

Database of Orthologous Groups

More...
OrthoDBi
738155at2759

TreeFam database of animal gene trees

More...
TreeFami
TF319820

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036427 Bromodomain-like_sf
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354 Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 3 hits
PS50016 ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGNGA ERVRVALRRG
60 70 80 90 100
GGAAGPGGAE PGEDTALLRL LGLRRGLRRL RRLWAGARVQ RGRGRGRGRG
110 120 130 140 150
WGPNRGCMPE EESSDGESEE EEFQGFHSDE DVAPSSLRSA LRSQRGRAPR
160 170 180 190 200
GRGRKHKTTP LPPRLADVTP VPPKAPTRKR GEEGTERMVQ ALTELLRRSQ
210 220 230 240 250
APQPPRSRAR AREPSTPRRS RGRPPGRPAG PCRKKQQAVV LAEAAVTIPK
260 270 280 290 300
PEPPPPVVPV KNKAGSWKCK EGPGPGPGTP KRGGQPGRGG RGGRGRGRGG
310 320 330 340 350
LPLMIKFVSK AKKVKMGQLS QELESGQGHG QRGESWQDAP QRKDGDEPER
360 370 380 390 400
GSCRKKQEQK LEEEEEEEEK EGEEKEEKDD NEDNNKQEEE EETERAVAEE
410 420 430 440 450
EAMLAKEKEE AKLPSPPLTP PVPSPPPPLP PPSTSPPPPA SPLPPPVSPP
460 470 480 490 500
PPLSPPPYPA PEKQEESPPL VPATCSRKRG RPPLTPSQRA EREAARSGPE
510 520 530 540 550
GTLSPTPNPS TTTGSPLEDS PTVVPKSTTF LKNIRQFIMP VVSARSSRVI
560 570 580 590 600
KTPRRFMDED PPKPPKVEAS IVRPPVATSP PAPQEPVPVS SPPRVPTPPS
610 620 630 640 650
TPVPLPEKRR SILREPTFRW TSLTRELPPP PPAPPPAPSP PPAPATPSRR
660 670 680 690 700
PLLLRAPQFT PSEAHLKIYE SVLTPPPLGA LETPEPELPP ADDSPAEPEP
710 720 730 740 750
RAVGRTNHLS LPRFVPVVTS PVKVEVPPHG APALSEGQQL QLQQPPQALQ
760 770 780 790 800
TQLLPQALPP QQPQAQPPPS PQHTPPLEKA RVASLGSLPL SGVEEKMFSL
810 820 830 840 850
LKRAKVQLFK IDQQQQQKVA ASMPLSPAVQ TEEAVGTVKQ TPDRGCVRSE
860 870 880 890 900
DESMEAKRDR ASGPESPLQG PRIKHVCRHA AVALGQARAM VPEDVPRLSA
910 920 930 940 950
LPLRDRQDLA TEDTSSASET ESVPSRSQRE KVESAGPGGD SEPTGSTGAL
960 970 980 990 1000
AHTPRRSLPS HHGKKMRMAR CGHCRGCLRV QDCGSCVNCL DKPKFGGPNT
1010 1020 1030 1040 1050
KKQCCVYRKC DKIEARKMER LAKKGRTIVK TLLPWDSDES PEASPGPPGP
1060 1070 1080 1090 1100
RRGAGAGGSR EEVGATPGPE EQDSLLLQRK SARRCVKQRP SYDVFEDSDD
1110 1120 1130 1140 1150
SEPGGPPAPR RRTPREHELP VLEPEEQSRP RKPTLQPVLQ LKARRRLDKD
1160 1170 1180 1190 1200
ALAPGPFASF PNGWTGKQKS PDGVHRVRVD FKEDCDLENV WLMGGLSVLT
1210 1220 1230 1240 1250
SVPGGPPMVC LLCASKGLHE LVFCQVCCDP FHPFCLEEAE RPSPQHRDTW
1260 1270 1280 1290 1300
CCRRCKFCHV CGRKGRGSKH LLECERCRHA YHPACLGPSY PTRATRRRRH
1310 1320 1330 1340 1350
WICSACVRCK SCGATPGKNW DVEWSGDYSL CPRCTELYEK GNYCPICTRC
1360 1370 1380 1390 1400
YEDNDYESKM MQCAQCDHWV HAKCEGLSDE DYEILSGLPD SVLYTCGPCA
1410 1420 1430 1440 1450
GATQPRWREA LSGALQGGLR QVLQGLLSSK VAGPLLLCTQ CGQDGKQLHP
1460 1470 1480 1490 1500
GPCDLQAVGK RFEEGLYKSV HSFMEDVVAI LMRHSEEGET PERRAGSQMK
1510 1520 1530 1540 1550
GLLLKLLESA FCWFDAHDPK YWRRSTRLPN GVLPNAVLPP SLDHVYAQWR
1560 1570 1580 1590 1600
QQESETPESG QPPGDPSAAF QSKDPAAFSH LDDPRQCALC LKYGDADSKE
1610 1620 1630 1640 1650
AGRLLYIGQN EWTHVNCAIW SAEVFEENDG SLKNVHAAVA RGRQMRCELC
1660 1670 1680 1690 1700
LKPGATVGCC LSSCLSNFHF MCARASYCIF QDDKKVFCQK HTDLLDGKEI
1710 1720 1730 1740 1750
VTPDGFDVLR RVYVDFEGIN FKRKFLTGLE PDVINVLIGS IRINSLGTLS
1760 1770 1780 1790 1800
DLSDCEGRLF PIGYQCSRLY WSTVDARRRC WYRCRILEYR PWGPREEPVH
1810 1820 1830 1840 1850
LEAAEENQTI VHSPTPSSDT DSLIPGDPVH HSPIQNLDPP LRTDSSNGPP
1860 1870 1880 1890 1900
PTPRSFSGAR IKVPNYSPSR RPLGGVSFGP LPSPGSPSSL THHIPTVGDS
1910 1920 1930 1940 1950
DFPAPPRRSR RPSPLATRPP PSRRTSSPLR TSPQLRVPLS TSVTALTPTS
1960 1970 1980 1990 2000
GELAPPDLAP SPLPPSEDLG PDFEDMEVVS GLSAADLDFA ASLLGTEPFQ
2010 2020 2030 2040 2050
EEIVAAGAVG SSQGGPGDSS EEEASPTTHY VHFPVTVVSG PALAPSSLAG
2060 2070 2080 2090 2100
APRIEQLDGV DDGTDSEAEA VQQPRGQGTP PSGPGVGRGG VLGAAGDRAQ
2110 2120 2130 2140 2150
PPEDLPSEIV DFVLKNLGGP GEGAAGPRED SLPSAPPLAN GSQPPQSLST
2160 2170 2180 2190 2200
SPADPTRTFA WLPGAPGVRV LSLGPAPEPP KPATSKIILV NKLGQVFVKM
2210 2220 2230 2240 2250
AGEGEPVAPP VKQPPLPPII PPTAPTSWTL PPGPLLSVLP VVGVGVVRPA
2260 2270 2280 2290 2300
PPPPPPPLTL VFSSGPPSPP RQAIRVKRVS TFSGRSPPVP PPNKTPRLDE
2310 2320 2330 2340 2350
DGESLEDAHH VPGISGSGFS RVRMKTPTVR GVLDLNNPGE QPEEESPGRP
2360 2370 2380 2390 2400
QDRCPLLPLA EAPSQALDGS SDLLFESQWH HYSAGEASSS EEEPPSPEDK
2410 2420 2430 2440 2450
ENQVPKRVGP HLRFEISSDD GFSVEAESLE VAWRTLIEKV QEARGHARLR
2460 2470 2480 2490 2500
HLSFSGMSGA RLLGIHHDAV IFLAEQLPGA QRCQHYKFRY HQQGEGQEEP
2510 2520 2530 2540 2550
PLNPHGAARA EVYLRKCTFD MFNFLASQHR VLPEGATCDE EEDEVQLRST
2560 2570 2580 2590 2600
RRATSLELPM AMRFRHLKKT SKEAVGVYRS AIHGRGLFCK RNIDAGEMVI
2610 2620 2630 2640 2650
EYSGIVIRSV LTDKREKFYD GKGIGCYMFR MDDFDVVDAT MHGNAARFIN
2660 2670 2680 2690 2700
HSCEPNCFSR VIHVEGQKHI VIFALRRILR GEELTYDYKF PIEDASNKLP
2710
CNCGAKRCRR FLN
Length:2,713
Mass (Da):294,821
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AD4343C5C081933
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WJ40F8WJ40_MOUSE
Histone-lysine N-methyltransferase
Kmt2b Wbp7
2,721Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W623F6W623_MOUSE
Histone-lysine N-methyltransferase ...
Kmt2b Wbp7
2,014Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC53192 differs from that shown. Possible contaminating sequence. The N-terminal 3 residues and C-terminal 8 residues do not match the underlying genomic sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18G → V in BAD81031 (Ref. 1) Curated1
Sequence conflicti25 – 27RGS → LGC in BAD81031 (Ref. 1) Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB182318 mRNA Translation: BAD81031.1
AC167970 Genomic DNA No translation available.
U92455 mRNA Translation: AAC53192.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21101.1

NCBI Reference Sequences

More...
RefSeqi
NP_083550.2, NM_029274.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.168688

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108154; ENSMUSP00000103789; ENSMUSG00000006307

Database of genes from NCBI RefSeq genomes

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GeneIDi
75410

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:75410

UCSC genome browser

More...
UCSCi
uc009gfg.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182318 mRNA Translation: BAD81031.1
AC167970 Genomic DNA No translation available.
U92455 mRNA Translation: AAC53192.1 Sequence problems.
CCDSiCCDS21101.1
RefSeqiNP_083550.2, NM_029274.2
UniGeneiMm.168688

3D structure databases

ProteinModelPortaliO08550
SMRiO08550
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217461, 3 interactors
CORUMiO08550
IntActiO08550, 1 interactor
MINTiO08550
STRINGi10090.ENSMUSP00000103789

PTM databases

iPTMnetiO08550
PhosphoSitePlusiO08550

Proteomic databases

EPDiO08550
jPOSTiO08550
MaxQBiO08550
PaxDbiO08550
PRIDEiO08550

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108154; ENSMUSP00000103789; ENSMUSG00000006307
GeneIDi75410
KEGGimmu:75410
UCSCiuc009gfg.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9757
MGIiMGI:109565 Kmt2b

Phylogenomic databases

eggNOGiKOG1084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000161496
HOGENOMiHOG000015326
HOVERGENiHBG100043
InParanoidiO08550
KOiK14959
OrthoDBi738155at2759
TreeFamiTF319820

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O08550

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000006307 Expressed in 245 organ(s), highest expression level in secondary oocyte
CleanExiMM_WBP7
ExpressionAtlasiO08550 baseline and differential
GenevisibleiO08550 MM

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR036427 Bromodomain-like_sf
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit
PIRSFiPIRSF010354 Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 3 hits
PS50016 ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKMT2B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08550
Secondary accession number(s): E9QKF4, Q5NU09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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