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Protein

Ephrin-A3

Gene

Efna3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.1 Publication

GO - Molecular functioni

  • ephrin receptor binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A3
Alternative name(s):
EHK1 ligand
Short name:
EHK1-L
EPH-related receptor tyrosine kinase ligand 3
Short name:
LERK-3
Gene namesi
Name:Efna3
Synonyms:Epl3, Eplg3, Lerk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106644 Efna3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000837123 – 206Ephrin-A3Add BLAST184
PropeptideiPRO_0000008372207 – 230Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi63 ↔ 102PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 150PROSITE-ProRule annotation
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi206GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO08545
PaxDbiO08545
PRIDEiO08545

PTM databases

iPTMnetiO08545
PhosphoSitePlusiO08545

Expressioni

Tissue specificityi

Expressed in myogenic progenitor cells.1 Publication

Developmental stagei

In myogenic progenitor cells, highly expressed at E11.5 and ceases its expression at the late fetal stage (E17.5).1 Publication

Gene expression databases

BgeeiENSMUSG00000028039 Expressed in 255 organ(s), highest expression level in olfactory epithelium
CleanExiMM_EFNA3
ExpressionAtlasiO08545 baseline and differential
GenevisibleiO08545 MM

Interactioni

Subunit structurei

Interacts with EPHA8; activates EPHA8.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029673

Structurei

3D structure databases

ProteinModelPortaliO08545
SMRiO08545
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 161Ephrin RBDPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiO08545
KOiK05462
OrthoDBiEOG091G0XCP
PhylomeDBiO08545

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08545-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT
60 70 80 90 100
VQVNVNDYLD IYCPHYNSSG PGGGAEQYVL YMVNLSGYRT CNASQGSKRW
110 120 130 140 150
ECNRQHASHS PIKFSEKFQR YSAFSLGYEF HAGQEYYYIS TPTHNLHWKC
160 170 180 190 200
LRMKVFVCCA STSHSGEKPV PTLPQFTMGP NVKINVLEDF EGENPQVPKL
210 220 230
EKSISGTSPK REHLPLAVGI AFFLMTLLAS
Length:230
Mass (Da):25,632
Last modified:January 9, 2007 - v4
Checksum:iC08AAA0D84B0D795
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGE9A0A0G2JGE9_MOUSE
Ephrin-A3
Efna3
204Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62Y → I in AAB50241 (PubMed:8903354).Curated1
Sequence conflicti76 – 77EQ → DR in AAB50241 (PubMed:8903354).Curated2
Sequence conflicti89 – 90RT → QP in AAB50241 (PubMed:8903354).Curated2
Sequence conflicti121Y → W in AAB50241 (PubMed:8903354).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107002 mRNA Translation: AAI07003.1
BC125003 mRNA Translation: AAI25004.1
U92885 Genomic DNA Translation: AAC39961.1
U90666 mRNA Translation: AAB50241.1
CCDSiCCDS38488.1
RefSeqiNP_034238.1, NM_010108.1
UniGeneiMm.331159

Genome annotation databases

EnsembliENSMUST00000029673; ENSMUSP00000029673; ENSMUSG00000028039
GeneIDi13638
KEGGimmu:13638
UCSCiuc008pyq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107002 mRNA Translation: AAI07003.1
BC125003 mRNA Translation: AAI25004.1
U92885 Genomic DNA Translation: AAC39961.1
U90666 mRNA Translation: AAB50241.1
CCDSiCCDS38488.1
RefSeqiNP_034238.1, NM_010108.1
UniGeneiMm.331159

3D structure databases

ProteinModelPortaliO08545
SMRiO08545
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029673

PTM databases

iPTMnetiO08545
PhosphoSitePlusiO08545

Proteomic databases

MaxQBiO08545
PaxDbiO08545
PRIDEiO08545

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029673; ENSMUSP00000029673; ENSMUSG00000028039
GeneIDi13638
KEGGimmu:13638
UCSCiuc008pyq.1 mouse

Organism-specific databases

CTDi1944
MGIiMGI:106644 Efna3

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiO08545
KOiK05462
OrthoDBiEOG091G0XCP
PhylomeDBiO08545

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

PROiPR:O08545
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028039 Expressed in 255 organ(s), highest expression level in olfactory epithelium
CleanExiMM_EFNA3
ExpressionAtlasiO08545 baseline and differential
GenevisibleiO08545 MM

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFNA3_MOUSE
AccessioniPrimary (citable) accession number: O08545
Secondary accession number(s): O55217, Q08AV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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