Efna5

Functionⁱ

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.4 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance
Source: MGI
Inferred from direct assayⁱ
- 9614241
brain development Source: MGI
cellular response to follicle-stimulating hormone stimulus
Source: MGI
Inferred from direct assayⁱ
- 23242526
cellular response to forskolin
Source: MGI
Inferred from direct assayⁱ
- 23242526
collateral sprouting
Source: BHF-UCL
Inferred from direct assayⁱ
- 19036963
ephrin receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 17448994
- 9053851
negative regulation of substrate adhesion-dependent cell spreading
Source: MGI
Inferred from sequence orthologyⁱ
- 23242526
positive regulation of collateral sprouting
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19036963
positive regulation of peptidyl-tyrosine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 17448994
positive regulation of synapse assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 19036963
regulation of actin cytoskeleton organization
Source: UniProtKB
Inferred from direct assayⁱ
- 17448994
regulation of cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 11089974
regulation of cell morphogenesis
Source: MGI
Inferred from sequence orthologyⁱ
- 23242526
regulation of focal adhesion assembly Source: UniProtKB
regulation of GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17448994
regulation of insulin secretion involved in cellular response to glucose stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17448994
regulation of microtubule cytoskeleton organization Source: UniProtKB
retinal ganglion cell axon guidance
Source: MGI
Inferred from direct assayⁱ
- 15996548
synaptic membrane adhesion
Source: SynGO
Inferred from direct assayⁱ
- 22275477

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Neurogenesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2682334 EPH-Ephrin signaling R-MMU-3928663 EPHA-mediated growth cone collapse R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Reactomeⁱ

R-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ephrin-A5 Alternative name(s): AL-1 EPH-related receptor tyrosine kinase ligand 7 Short name: LERK-7
Gene namesⁱ	Name:Efna5 Synonyms:Epl7, Eplg7, Lerk7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:107444 Efna5

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice display cataract an opacification of the lens.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
ChainⁱPRO_0000008379	21 – 203	Ephrin-A5Add BLAST	183
PropeptideⁱPRO_0000008380	204 – 228	Removed in mature formSequence analysisAdd BLAST	25

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	37	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	62 ↔ 102	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	90 ↔ 151	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	162	N-linked (GlcNAc...) asparagine; atypical1 Publication	1
Lipidationⁱ	203	GPI-anchor amidated asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbⁱ	O08543
PRIDEⁱ	O08543

PTM databases

iPTMnetⁱ	O08543
PhosphoSitePlusⁱ	O08543

Expressionⁱ

Tissue specificityⁱ

Expressed in myogenic progenitor cells.1 Publication

Developmental stageⁱ

In myogenic progenitor cells, highly expressed at E11.5 and ceases its expression at the late fetal stage (E17.5).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000048915 Expressed in 289 organ(s), highest expression level in ear
CleanExⁱ	MM_EFNA5
Genevisibleⁱ	O08543 MM

Interactionⁱ

Subunit structureⁱ

Binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function (By similarity). Binds to EPHB2. Interacts with EPHA8; activates EPHA8.By similarity2 Publications

GO - Molecular functionⁱ

chemorepellent activity
Source: MGI
Inferred from direct assayⁱ
- 15996548
ephrin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11089974
- 9053851
neurotrophin TRKB receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19036963

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	O08543, 2 interactors
STRINGⁱ	10090.ENSMUSP00000076115

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 35	Combined sources	6
Helixⁱ	41 – 44	Combined sources	4
Beta strandⁱ	49 – 52	Combined sources	4
Beta strandⁱ	57 – 61	Combined sources	5
Beta strandⁱ	67 – 69	Combined sources	3
Beta strandⁱ	71 – 73	Combined sources	3
Beta strandⁱ	77 – 82	Combined sources	6
Helixⁱ	84 – 88	Combined sources	5
Beta strandⁱ	92 – 102	Combined sources	11
Beta strandⁱ	108 – 111	Combined sources	4
Beta strandⁱ	113 – 117	Combined sources	5
Beta strandⁱ	134 – 144	Combined sources	11
Beta strandⁱ	148 – 150	Combined sources	3
Beta strandⁱ	153 – 158	Combined sources	6
Turnⁱ	161 – 164	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	O08543
SMRⁱ	O08543
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O08543

EvolutionaryTraceⁱ

O08543

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	29 – 162	Ephrin RBDPROSITE-ProRule annotationAdd BLAST		134

Sequence similaritiesⁱ

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3858 Eukaryota ENOG4111FMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015107
HOGENOMⁱ	HOG000234373
HOVERGENⁱ	HBG051447
InParanoidⁱ	O08543
KEGG Orthology (KO) More...KOⁱ	K05462
OMAⁱ	CVKTIGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IJF
PhylomeDBⁱ	O08543

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Dⁱ	2.60.40.420, 1 hit
InterProⁱ	View protein in InterPro IPR008972 Cupredoxin IPR031328 Ephrin IPR034252 Ephrin-A_Ecto IPR019765 Ephrin_CS IPR001799 Ephrin_RBD
PANTHERⁱ	PTHR11304 PTHR11304, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00812 Ephrin, 1 hit
PRINTSⁱ	PR01347 EPHRIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002533 Ephrin, 1 hit
SUPFAMⁱ	SSF49503 SSF49503, 1 hit
PROSITEⁱ	View protein in PROSITE PS01299 EPHRIN_RBD_1, 1 hit PS51551 EPHRIN_RBD_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform Long (identifier: O08543-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHVEMLTLL FLVLWMCVFS QDPGSKVVAD RYAVYWNSSN PRFQRGDYHI 
        60         70         80         90        100
DVCINDYLDV FCPHYEDSVP EDKTERYVLY MVNFDGYSAC DHTSKGFKRW 
       110        120        130        140        150
ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYFYIS SAIPDNGRRS 
       160        170        180        190        200
CLKLKVFVRP TNSCMKTIGV HDRVFDVNDK VENSLEPADD TVHESAEPSR 
       210        220 
GENAAQTPRI PSRLLAILLF LLAMLLTL

Length:228

Mass (Da):26,339

Last modified:July 1, 1997 - v1

Checksum:ⁱ85439F5337420022

GO

Isoform Short (identifier: O08543-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
163-189: Missing.

« Hide

        10         20         30         40         50
MLHVEMLTLL FLVLWMCVFS QDPGSKVVAD RYAVYWNSSN PRFQRGDYHI 
        60         70         80         90        100
DVCINDYLDV FCPHYEDSVP EDKTERYVLY MVNFDGYSAC DHTSKGFKRW 
       110        120        130        140        150
ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYFYIS SAIPDNGRRS 
       160        170        180        190        200
CLKLKVFVRP TNDTVHESAE PSRGENAAQT PRIPSRLLAI LLFLLAMLLT 

L

Show »

Length:201

Mass (Da):23,338

Checksum:ⁱC5F5E78FD6674316

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001449	163 – 189	Missing in isoform Short. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U90664 mRNA Translation: AAB50239.1 U90665 mRNA Translation: AAB50240.1 BC040218 mRNA Translation: AAH40218.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28934.1 [O08543-2] CCDS28935.1 [O08543-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_034239.1, NM_010109.3 [O08543-2] NP_997537.1, NM_207654.2 [O08543-1]
UniGeneⁱ	Mm.401670 Mm.7978

Genome annotation databases

Ensemblⁱ	ENSMUST00000076840; ENSMUSP00000076115; ENSMUSG00000048915 [O08543-1] ENSMUST00000078839; ENSMUSP00000077883; ENSMUSG00000048915 [O08543-2]
GeneIDⁱ	13640
KEGGⁱ	mmu:13640
UCSC genome browser More...UCSCⁱ	uc008dfg.2 mouse [O08543-1] uc008dfh.2 mouse [O08543-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08543	ephrin-A5 isoform X1		MESAU		228	UniRef100_O08543
Ephrin-A5 isoform a (Fragment)		MESAU		208
O08543-2	ephrin-A5 isoform X2		MESAU		201	UniRef100_O08543-2

Protein	Similar proteins		Species	Score	Length	Source
O08543	Ephrin-A5		RAT		228	UniRef90_O08543
Ephrin-A5	)	HUMAN		228
Ephrin-A5		CHICK		228
ephrin-A5 isoform X1		MESAU		228
Ephrin A5		MUSPF		260
+115
O08543-2	ephrin-A5 isoform X2		MESAU		201	UniRef90_O08543-2
Ephrin-A5		CASCN		201
ephrin-A5 isoform X2		DIPOR		201
Ephrin-A5		HUMAN		201
EFNA5 isoform 3		PANTR		201
+62

Protein	Similar proteins		Species	Score	Length	Source
O08543	Ephrin-A5		RAT		228	UniRef50_O08543
Ephrin-A5		CHICK		228
Ephrin-A5	)	HUMAN		228
ephrin-A5 isoform X1		MESAU		228
Ephrin A5		MUSPF		260
+236
O08543-2	ephrin-A5 isoform X2		MESAU		201	UniRef50_O08543-2
Ephrin-A5		HUMAN		201
EFNA5 isoform 3		PANTR		201
Ephrin A5		SAIBB		201
Uncharacterized protein		PROCO		201
+95

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U90664 mRNA Translation: AAB50239.1 U90665 mRNA Translation: AAB50240.1 BC040218 mRNA Translation: AAH40218.1
CCDSⁱ	CCDS28934.1 [O08543-2] CCDS28935.1 [O08543-1]
RefSeqⁱ	NP_034239.1, NM_010109.3 [O08543-2] NP_997537.1, NM_207654.2 [O08543-1]
UniGeneⁱ	Mm.401670 Mm.7978

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SHW	X-ray	2.20	A	28-164	[»]
	1SHX	X-ray	2.10	A/B	28-164	[»]
ProteinModelPortalⁱ	O08543
SMRⁱ	O08543
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O08543, 2 interactors
STRINGⁱ	10090.ENSMUSP00000076115

PTM databases

iPTMnetⁱ	O08543
PhosphoSitePlusⁱ	O08543

Proteomic databases

PaxDbⁱ	O08543
PRIDEⁱ	O08543

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000076840; ENSMUSP00000076115; ENSMUSG00000048915 [O08543-1] ENSMUST00000078839; ENSMUSP00000077883; ENSMUSG00000048915 [O08543-2]
GeneIDⁱ	13640
KEGGⁱ	mmu:13640
UCSCⁱ	uc008dfg.2 mouse [O08543-1] uc008dfh.2 mouse [O08543-2]

Organism-specific databases

CTDⁱ	1946
MGIⁱ	MGI:107444 Efna5

Phylogenomic databases

eggNOGⁱ	KOG3858 Eukaryota ENOG4111FMJ LUCA
GeneTreeⁱ	ENSGT00390000015107
HOGENOMⁱ	HOG000234373
HOVERGENⁱ	HBG051447
InParanoidⁱ	O08543
KOⁱ	K05462
OMAⁱ	CVKTIGV
OrthoDBⁱ	EOG091G0IJF
PhylomeDBⁱ	O08543

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2682334 EPH-Ephrin signaling R-MMU-3928663 EPHA-mediated growth cone collapse R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Reactomeⁱ

R-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

ChiTaRSⁱ	Efna5 mouse
EvolutionaryTraceⁱ	O08543
Protein Ontology More...PROⁱ	PR:O08543
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000048915 Expressed in 289 organ(s), highest expression level in ear
CleanExⁱ	MM_EFNA5
Genevisibleⁱ	O08543 MM

Family and domain databases

CDDⁱ	cd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Dⁱ	2.60.40.420, 1 hit
InterProⁱ	View protein in InterPro IPR008972 Cupredoxin IPR031328 Ephrin IPR034252 Ephrin-A_Ecto IPR019765 Ephrin_CS IPR001799 Ephrin_RBD
PANTHERⁱ	PTHR11304 PTHR11304, 1 hit
Pfamⁱ	View protein in Pfam PF00812 Ephrin, 1 hit
PRINTSⁱ	PR01347 EPHRIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002533 Ephrin, 1 hit
SUPFAMⁱ	SSF49503 SSF49503, 1 hit
PROSITEⁱ	View protein in PROSITE PS01299 EPHRIN_RBD_1, 1 hit PS51551 EPHRIN_RBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EFNA5_MOUSE
Accessionⁱ	O08543Primary (citable) accession number: O08543 Secondary accession number(s): O08544
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniRef

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Supporting data

UniProtKB - O08543 (EFNA5_MOUSE)

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Ephrin-A5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ