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Protein

Ephrin-A4

Gene

Efna4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: GO_Central
  • bone remodeling Source: GO_Central
  • ephrin receptor signaling pathway Source: GO_Central
  • osteoclast differentiation Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A4
Alternative name(s):
EPH-related receptor tyrosine kinase ligand 4
Short name:
LERK-4
Gene namesi
Name:Efna4
Synonyms:Epl4, Eplg4, Lerk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106643 Efna4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000837526 – 175Ephrin-A4Add BLAST150
PropeptideiPRO_0000008376176 – 206Removed in mature formSequence analysisAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi58 ↔ 99PROSITE-ProRule annotation
Disulfide bondi86 ↔ 147PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi175GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO08542
PRIDEiO08542

PTM databases

PhosphoSitePlusiO08542

Expressioni

Tissue specificityi

Expressed in myogenic progenitor cells.1 Publication

Developmental stagei

In myogenic progenitor cells, highly expressed at E11.5 and ceases its expression at the late fetal stage (E17.5).1 Publication

Gene expression databases

BgeeiENSMUSG00000028040 Expressed in 142 organ(s), highest expression level in spinal cord
CleanExiMM_EFNA4
ExpressionAtlasiO08542 baseline and differential
GenevisibleiO08542 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08542, 2 interactors
MINTiO08542
STRINGi10090.ENSMUSP00000029674

Structurei

3D structure databases

ProteinModelPortaliO08542
SMRiO08542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 158Ephrin RBDPROSITE-ProRule annotationAdd BLAST133

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 43Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiO08542
KOiK05462
OMAiVCCKESR
OrthoDBiEOG091G0K52
PhylomeDBiO08542

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08542-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLPLLRTV LWAALLGSRL PGCSSLRHPI YWNSSNPRLL RGDAVVELGF
60 70 80 90 100
NDYLDIFCPH YESPGPPEGP ETFALYMVDW SGYEACTAEG ANAFQRWNCS
110 120 130 140 150
MPFAPFSPVR FSEKIQRYTP FPLGFEFLPG ETYYYISVPT PESPGRCLRL
160 170 180 190 200
QVSVCCKESG SSHESAHPVG SPGESGTSGW RGGHAPSPLC LLLLLLLPIL

RLLRVL
Length:206
Mass (Da):22,861
Last modified:July 15, 1999 - v2
Checksum:i43501971DD1C6EA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 4MRLL → MLLRLGLIYPPTRPPAPPGP LV (PubMed:8903354).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90663 mRNA Translation: AAB50238.1
U92890, U92889 Genomic DNA Translation: AAC39962.1
CCDSiCCDS38489.1
RefSeqiNP_031936.2, NM_007910.2
UniGeneiMm.16332

Genome annotation databases

EnsembliENSMUST00000029674; ENSMUSP00000029674; ENSMUSG00000028040
GeneIDi13639
KEGGimmu:13639
UCSCiuc008pys.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90663 mRNA Translation: AAB50238.1
U92890, U92889 Genomic DNA Translation: AAC39962.1
CCDSiCCDS38489.1
RefSeqiNP_031936.2, NM_007910.2
UniGeneiMm.16332

3D structure databases

ProteinModelPortaliO08542
SMRiO08542
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08542, 2 interactors
MINTiO08542
STRINGi10090.ENSMUSP00000029674

PTM databases

PhosphoSitePlusiO08542

Proteomic databases

PaxDbiO08542
PRIDEiO08542

Protocols and materials databases

DNASUi13639
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029674; ENSMUSP00000029674; ENSMUSG00000028040
GeneIDi13639
KEGGimmu:13639
UCSCiuc008pys.1 mouse

Organism-specific databases

CTDi1945
MGIiMGI:106643 Efna4

Phylogenomic databases

eggNOGiKOG3858 Eukaryota
ENOG4111FMJ LUCA
GeneTreeiENSGT00390000015107
HOGENOMiHOG000234373
HOVERGENiHBG051447
InParanoidiO08542
KOiK05462
OMAiVCCKESR
OrthoDBiEOG091G0K52
PhylomeDBiO08542

Enzyme and pathway databases

ReactomeiR-MMU-2682334 EPH-Ephrin signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

PROiPR:O08542
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028040 Expressed in 142 organ(s), highest expression level in spinal cord
CleanExiMM_EFNA4
ExpressionAtlasiO08542 baseline and differential
GenevisibleiO08542 MM

Family and domain databases

CDDicd10425 Ephrin-A_Ectodomain, 1 hit
Gene3Di2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR031328 Ephrin
IPR034252 Ephrin-A_Ecto
IPR019765 Ephrin_CS
IPR001799 Ephrin_RBD
PANTHERiPTHR11304 PTHR11304, 1 hit
PfamiView protein in Pfam
PF00812 Ephrin, 1 hit
PRINTSiPR01347 EPHRIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002533 Ephrin, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
PROSITEiView protein in PROSITE
PS01299 EPHRIN_RBD_1, 1 hit
PS51551 EPHRIN_RBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFNA4_MOUSE
AccessioniPrimary (citable) accession number: O08542
Secondary accession number(s): O55218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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