Esr2

Functionⁱ

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	149 – 214	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	66
Zinc fingerⁱ	149 – 169	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	185 – 209	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 9058381
drug binding Source: MGI
enzyme binding Source: MGI
estradiol binding Source: MGI
estrogen receptor activity Source: MGI
estrogen response element binding Source: MGI
hormone binding Source: MGI
identical protein binding Source: MGI
peroxisome proliferator activated receptor binding Source: MGI
promoter-specific chromatin binding Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding Source: MGI
sequence-specific DNA binding Source: MGI
steroid binding Source: UniProtKB
steroid hormone binding Source: MGI
steroid hormone receptor activity Source: MGI
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral fear response Source: MGI
brain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 12515851
cellular response to estradiol stimulus Source: MGI
epithelial cell maturation involved in prostate gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15187231
estrous cycle Source: MGI
hormone-mediated apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 15187231
intracellular estrogen receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 12370428
intracellular steroid hormone receptor signaling pathway Source: MGI
learning or memory Source: MGI
negative regulation of androgen receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 12370428
negative regulation of behavior Source: MGI
negative regulation of cell death Source: MGI
negative regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 18464259
negative regulation of epithelial cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12370428
- 15187231
negative regulation of feeding behavior Source: MGI
negative regulation of neuron death Source: MGI
negative regulation of reactive oxygen species metabolic process Source: MGI
negative regulation of smooth muscle cell proliferation Source: MGI
negative regulation of transcription by RNA polymerase II Source: MGI
neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 12515851
ovarian follicle development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10976058
- 9861029
positive regulation of apoptotic process Source: MGI
positive regulation of blood vessel diameter Source: MGI
positive regulation of DNA-binding transcription factor activity Source: UniProtKB
positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
positive regulation of ERK1 and ERK2 cascade Source: MGI
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: MGI
prostate gland epithelium morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 12370428
- 15187231
regulation of cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9697695
regulation of neuron apoptotic process Source: MGI
response to testosterone Source: MGI
Sertoli cell proliferation Source: MGI
uterus development
Source: MGI
Inferred from genetic interactionⁱ
- 10976058
vagina development
Source: MGI
Inferred from genetic interactionⁱ
- 10976058

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1257604 PIP3 activates AKT signaling R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8939211 ESR-mediated signaling

Reactomeⁱ

R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8939211 ESR-mediated signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Estrogen receptor beta Short name: ER-beta Alternative name(s): Nuclear receptor subfamily 3 group A member 2
Gene namesⁱ	Name:Esr2 Synonyms:Estrb, Nr3a2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:109392 Esr2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	105	S → A: Abolishes stimulatory effect of Ras. 1 Publication		1
Mutagenesisⁱ	139	S → A: No loss of the stimulatory effect of Ras. 1 Publication		1

Chemistry databases

ChEMBLⁱ	CHEMBL2995
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	621

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053644	1 – 530	Estrogen receptor betaAdd BLAST		530

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	61	Phosphoserine; alternate1 Publication	1
GlycosylationⁱCAR_000201	61	O-linked (GlcNAc) serine; alternate1 Publication	1
Modified residueⁱ	87	Phosphoserine; by MAPK1 Publication	1
Modified residueⁱ	105	Phosphoserine; by MAPK1 Publication	1

Post-translational modificationⁱ

Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.2 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	O08537
PRIDEⁱ	O08537

PTM databases

GlyConnectⁱ	146
iPTMnetⁱ	O08537
PhosphoSitePlusⁱ	O08537
UniCarbKBⁱ	O08537

Expressionⁱ

Tissue specificityⁱ

Expressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis.1 Publication

Inductionⁱ

Isoforms 1 and 2 are down-regulated by 17-beta-estradiol.1 Publication

Gene expression databases

CleanExⁱ	MM_ESR2
ExpressionAtlasⁱ	O08537 baseline and differential

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DNAAF4. Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Fos	P01101	2	EBI-2526214,EBI-4288185

With

Entry

#Exp.

IntAct

Notes

Fos

P01101

2

EBI-2526214,EBI-4288185

GO - Molecular functionⁱ

enzyme binding Source: MGI
identical protein binding Source: MGI
peroxisome proliferator activated receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199522, 3 interactors
IntActⁱ	O08537, 2 interactors
STRINGⁱ	10090.ENSMUSP00000098849

Chemistry databases

BindingDBⁱ

O08537

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08537
SMRⁱ	O08537
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	264 – 498	NR LBDPROSITE-ProRule annotationAdd BLAST		235

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 148	ModulatingAdd BLAST		148

Domainⁱ

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	149 – 169	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	185 – 209	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000233468
HOVERGENⁱ	HBG108344
InParanoidⁱ	O08537
KEGG Orthology (KO) More...KOⁱ	K08551
TreeFamⁱ	TF323751

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR028355 ER-beta/gamma IPR021064 Estrogen_rcpt_beta_N IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR024178 Oest_rcpt/oest-rel_rcp IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12497 ERbeta_N, 1 hit PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF500102 ER-b, 1 hit PIRSF002527 ER-like_NR, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 2 hits
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O08537-1) [UniParc]FASTA Add to basket

Also known as: Beta-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS 
        60         70         80         90        100
PAVMNYSVPS STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA 
       110        120        130        140        150
EPQKSPWCEA RSLEHTLPVN RETLKRKLGG SGCASPVTSP SAKRDAHFCA 
       160        170        180        190        200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS 
       210        220        230        240        250
CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH CLNKAKRTSG 
       260        270        280        290        300
HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 
       310        320        330        340        350
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH 
       360        370        380        390        400
PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTARFREL KLQHKEYLCV 
       410        420        430        440        450
KAMILLNSSM YPLATASQEA ESSRKLTHLL NAVTDALVWV ISKSGISSQQ 
       460        470        480        490        500
QSVRLANLLM LLSHVRHISN KGMEHLLSMK CKNVVPVYDL LLEMLNAHTL 
       510        520        530
RGYKSSISGS ECCSTEDSKS KEGSQNLQSQ

Length:530

Mass (Da):59,070

Last modified:March 21, 2012 - v3

Checksum:ⁱBEFA25F62650A8D4

GO

Isoform 2 (identifier: O08537-2) [UniParc]FASTA Add to basket

Also known as: Beta-2

The sequence of this isoform differs from the canonical sequence as follows:
364-364: R → RSSEDPHWHVAQTKSAVPR

« Hide

        10         20         30         40         50
MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS 
        60         70         80         90        100
PAVMNYSVPS STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA 
       110        120        130        140        150
EPQKSPWCEA RSLEHTLPVN RETLKRKLGG SGCASPVTSP SAKRDAHFCA 
       160        170        180        190        200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS 
       210        220        230        240        250
CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH CLNKAKRTSG 
       260        270        280        290        300
HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 
       310        320        330        340        350
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH 
       360        370        380        390        400
PGKLIFAPDL VLDRSSEDPH WHVAQTKSAV PRDEGKCVEG ILEIFDMLLA 
       410        420        430        440        450
TTARFRELKL QHKEYLCVKA MILLNSSMYP LATASQEAES SRKLTHLLNA 
       460        470        480        490        500
VTDALVWVIS KSGISSQQQS VRLANLLMLL SHVRHISNKG MEHLLSMKCK 
       510        520        530        540 
NVVPVYDLLL EMLNAHTLRG YKSSISGSEC CSTEDSKSKE GSQNLQSQ

Show »

Length:548

Mass (Da):61,084

Checksum:ⁱ5A3BFF5FCD158E7C

GO

Isoform 3 (identifier: O08537-4) [UniParc]FASTA Add to basket

Also known as: Beta-5A

The sequence of this isoform differs from the canonical sequence as follows:
319-409: Missing.

« Hide

        10         20         30         40         50
MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS 
        60         70         80         90        100
PAVMNYSVPS STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA 
       110        120        130        140        150
EPQKSPWCEA RSLEHTLPVN RETLKRKLGG SGCASPVTSP SAKRDAHFCA 
       160        170        180        190        200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS 
       210        220        230        240        250
CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH CLNKAKRTSG 
       260        270        280        290        300
HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 
       310        320        330        340        350
LADKELVHMI GWAKKIPGMY PLATASQEAE SSRKLTHLLN AVTDALVWVI 
       360        370        380        390        400
SKSGISSQQQ SVRLANLLML LSHVRHISNK GMEHLLSMKC KNVVPVYDLL 
       410        420        430 
LEMLNAHTLR GYKSSISGSE CCSTEDSKSK EGSQNLQSQ

Note: Corresponds to exons 5 and 6 deletion.1 Publication

Show »

Length:439

Mass (Da):48,550

Checksum:ⁱFCA85E5235E368D2

GO

Isoform 4 (identifier: O08537-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
319-343: FVELSLLDQVRLLESCWMEVLMVGL → MRGSAWKGFWKSLTCSWRRRHGSVS
344-530: Missing.

« Hide

        10         20         30         40         50
MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS 
        60         70         80         90        100
PAVMNYSVPS STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA 
       110        120        130        140        150
EPQKSPWCEA RSLEHTLPVN RETLKRKLGG SGCASPVTSP SAKRDAHFCA 
       160        170        180        190        200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS 
       210        220        230        240        250
CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH CLNKAKRTSG 
       260        270        280        290        300
HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 
       310        320        330        340 
LADKELVHMI GWAKKIPGMR GSAWKGFWKS LTCSWRRRHG SVS

Note: Corresponds to exon 5 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.1 Publication

Show »

Length:343

Mass (Da):38,185

Checksum:ⁱ0073C2E153F493D3

GO

Isoform 5 (identifier: O08537-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
365-377: DEGKCVEGILEIF → YVPLGYRKPGSRE
378-530: Missing.

« Hide

        10         20         30         40         50
MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS 
        60         70         80         90        100
PAVMNYSVPS STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA 
       110        120        130        140        150
EPQKSPWCEA RSLEHTLPVN RETLKRKLGG SGCASPVTSP SAKRDAHFCA 
       160        170        180        190        200
VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS 
       210        220        230        240        250
CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH CLNKAKRTSG 
       260        270        280        290        300
HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 
       310        320        330        340        350
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH 
       360        370 
PGKLIFAPDL VLDRYVPLGY RKPGSRE

Note: Corresponds to exon 6 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.1 Publication

Show »

Length:377

Mass (Da):42,107

Checksum:ⁱ59314206E084E413

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W2P736	A0A1W2P736_MOUSE	Estrogen receptor beta Estrogen receptor beta	Esr2	567	Annotation score:
A0A0R4J0Y6	A0A0R4J0Y6_MOUSE	Estrogen receptor beta Estrogen receptor beta	Esr2	549	Annotation score:
A0A0R4J191	A0A0R4J191_MOUSE	Estrogen receptor beta Estrogen receptor beta	Esr2	548	Annotation score:
A0A0R4J1F1	A0A0R4J1F1_MOUSE	Estrogen receptor beta Estrogen receptor beta	Esr2	530	Annotation score:
S4R2G7	S4R2G7_MOUSE	Estrogen receptor beta Estrogen receptor beta	Esr2	343	Annotation score:

Sequence cautionⁱ

The sequence AAC17919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAI41076 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAI45330 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAL15175 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAC35719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAC35770 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	47	T → A in CAA03949 (PubMed:9280064).Curated	1
Sequence conflictⁱ	142	A → T in CAA03949 (PubMed:9280064).Curated	1
Sequence conflictⁱ	200	S → N in CAA03949 (PubMed:9280064).Curated	1
Sequence conflictⁱ	378	D → G in AAB51132 (PubMed:16141072).Curated	1
Sequence conflictⁱ	378	D → G in AAL15175 (PubMed:11878304).Curated	1
Sequence conflictⁱ	412	P → H in CAA03949 (PubMed:9280064).Curated	1
Sequence conflictⁱ	445	G → R in CAA03949 (PubMed:9280064).Curated	1
Sequence conflictⁱ	511	E → G in CAA03949 (PubMed:9280064).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_003696	319 – 409	Missing in isoform 3. CuratedAdd BLAST	91
Alternative sequenceⁱVSP_042429	319 – 343	FVELS…LMVGL → MRGSAWKGFWKSLTCSWRRR HGSVS in isoform 4. CuratedAdd BLAST	25
Alternative sequenceⁱVSP_042430	344 – 530	Missing in isoform 4. CuratedAdd BLAST	187
Alternative sequenceⁱVSP_003693	364	R → RSSEDPHWHVAQTKSAVPR in isoform 2. 2 Publications	1
Alternative sequenceⁱVSP_042431	365 – 377	DEGKC…ILEIF → YVPLGYRKPGSRE in isoform 5. CuratedAdd BLAST	13
Alternative sequenceⁱVSP_042432	378 – 530	Missing in isoform 5. CuratedAdd BLAST	153

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK054290 mRNA Translation: BAC35719.1 Different initiation. AK054413 mRNA Translation: BAC35770.1 Different initiation. AC164121 Genomic DNA No translation available. BC141075 mRNA Translation: AAI41076.1 Different initiation. BC145329 mRNA Translation: AAI45330.1 Different initiation. U81451 mRNA Translation: AAB51132.1 AJ000220 Genomic DNA Translation: CAA03949.1 AY054413 mRNA Translation: AAL15175.1 Different initiation. AF067422 mRNA Translation: AAC17919.1 Different initiation. AF063853 mRNA Translation: AAC16656.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034287.3, NM_010157.3 NP_997590.1, NM_207707.1
UniGeneⁱ	Mm.2561

Genome annotation databases

Ensemblⁱ	ENSMUST00000101291; ENSMUSP00000098849; ENSMUSG00000021055 [O08537-2] ENSMUST00000110421; ENSMUSP00000106051; ENSMUSG00000021055 [O08537-1] ENSMUST00000133564; ENSMUSP00000138637; ENSMUSG00000021055 [O08537-6]
GeneIDⁱ	13983
KEGGⁱ	mmu:13983
UCSC genome browser More...UCSCⁱ	uc007nxu.1 mouse [O08537-2] uc007nxv.1 mouse [O08537-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08537	Estrogen receptor beta		MOUSE		549	UniRef100_O08537
Estrogen receptor beta		MOUSE		530
O08537-2	Estrogen receptor beta		MOUSE		567	UniRef100_A0A1W2P736
Estrogen receptor beta		MOUSE		548
Estrogen receptor beta (Fragment)		MOUSE		139
O08537-6	Estrogen receptor beta		MOUSE		343	UniRef100_S4R2G7

Protein	Similar proteins		Species	Score	Length	Source
O08537	Estrogen receptor beta	)	RAT		530	UniRef90_Q62986
Estrogen receptor beta		MOUSE		567
Estrogen receptor 2 (Beta) (Fragment)		MICOH		369
Estrogen receptor beta		CRIGR		58
UPI0004ED5BFB		NANGA		567
+17
O08537-6	Isoform 5 of Estrogen receptor beta		MOUSE		377	UniRef90_O08537-7
Estrogen receptor beta		MOUSE		343
O08537-7	Estrogen receptor beta		MOUSE		343	UniRef90_O08537-7
Isoform 4 of Estrogen receptor beta		MOUSE		343

Protein	Similar proteins		Species	Score	Length	Source
O08537	Estrogen receptor beta	)	RAT		530	UniRef50_Q62986
Estrogen receptor beta-1		CARAU		568
Estrogen receptor beta		ORENI		557
Estrogen receptor beta		ANGJA		573
Estrogen receptor gamma		MICUN		565
+242
O08537-4	estrogen receptor beta isoform X3		TARSY		458	UniRef50_O08537-4
estrogen receptor beta isoform X2		NEOSC		439
estrogen receptor beta isoform X2		ODORO		458
Uncharacterized protein		FELCA		440
estrogen receptor beta isoform X2		Enhydra lutris kenyoni		439
+53
O08537-6	Isoform 3 of Estrogen receptor beta		MOUSE		439	UniRef50_O08537-4
estrogen receptor beta isoform X3		TARSY		458
estrogen receptor beta isoform X2		NEOSC		439
estrogen receptor beta isoform X2		ODORO		458
Uncharacterized protein		FELCA		440
+53
O08537-7	Isoform 3 of Estrogen receptor beta		MOUSE		439	UniRef50_O08537-4
estrogen receptor beta isoform X3		TARSY		458
estrogen receptor beta isoform X2		NEOSC		439
estrogen receptor beta isoform X2		ODORO		458
Uncharacterized protein		FELCA		440
+53

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK054290 mRNA Translation: BAC35719.1 Different initiation. AK054413 mRNA Translation: BAC35770.1 Different initiation. AC164121 Genomic DNA No translation available. BC141075 mRNA Translation: AAI41076.1 Different initiation. BC145329 mRNA Translation: AAI45330.1 Different initiation. U81451 mRNA Translation: AAB51132.1 AJ000220 Genomic DNA Translation: CAA03949.1 AY054413 mRNA Translation: AAL15175.1 Different initiation. AF067422 mRNA Translation: AAC17919.1 Different initiation. AF063853 mRNA Translation: AAC16656.1
RefSeqⁱ	NP_034287.3, NM_010157.3 NP_997590.1, NM_207707.1
UniGeneⁱ	Mm.2561

3D structure databases

ProteinModelPortalⁱ	O08537
SMRⁱ	O08537
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199522, 3 interactors
IntActⁱ	O08537, 2 interactors
STRINGⁱ	10090.ENSMUSP00000098849

Chemistry databases

BindingDBⁱ	O08537
ChEMBLⁱ	CHEMBL2995
GuidetoPHARMACOLOGYⁱ	621

PTM databases

GlyConnectⁱ	146
iPTMnetⁱ	O08537
PhosphoSitePlusⁱ	O08537
UniCarbKBⁱ	O08537

Proteomic databases

PaxDbⁱ	O08537
PRIDEⁱ	O08537

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000101291; ENSMUSP00000098849; ENSMUSG00000021055 [O08537-2] ENSMUST00000110421; ENSMUSP00000106051; ENSMUSG00000021055 [O08537-1] ENSMUST00000133564; ENSMUSP00000138637; ENSMUSG00000021055 [O08537-6]
GeneIDⁱ	13983
KEGGⁱ	mmu:13983
UCSCⁱ	uc007nxu.1 mouse [O08537-2] uc007nxv.1 mouse [O08537-1]

Organism-specific databases

CTDⁱ	2100
MGIⁱ	MGI:109392 Esr2

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000233468
HOVERGENⁱ	HBG108344
InParanoidⁱ	O08537
KOⁱ	K08551
TreeFamⁱ	TF323751

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1257604 PIP3 activates AKT signaling R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8939211 ESR-mediated signaling

Reactomeⁱ

R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8939211 ESR-mediated signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O08537
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_ESR2
ExpressionAtlasⁱ	O08537 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR028355 ER-beta/gamma IPR021064 Estrogen_rcpt_beta_N IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR024178 Oest_rcpt/oest-rel_rcp IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF12497 ERbeta_N, 1 hit PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF500102 ER-b, 1 hit PIRSF002527 ER-like_NR, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 2 hits
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ESR2_MOUSE
Accessionⁱ	O08537Primary (citable) accession number: O08537 Secondary accession number(s): B2RUC6 , E9QKX7, O35635, O70519, Q8BG65, Q91Z86
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	March 21, 2012
	Last modified:	September 12, 2018
	This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O08537 (ESR2_MOUSE)

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Estrogen receptor beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ