Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-tectorin

Gene

Tectb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: MGI

GO - Biological processi

  • sensory perception of sound Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-tectorin
Gene namesi
Name:Tectb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:109574 Tectb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004174318 – 305Beta-tectorinAdd BLAST288
PropeptideiPRO_0000041744306 – 329Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 264By similarity
Lipidationi305GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO08524
PRIDEiO08524

Expressioni

Gene expression databases

BgeeiENSMUSG00000024979 Expressed in 33 organ(s), highest expression level in epithelium of cochlear duct
CleanExiMM_TECTB
ExpressionAtlasiO08524 baseline and differential
GenevisibleiO08524 MM

Interactioni

Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025936

Structurei

3D structure databases

ProteinModelPortaliO08524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 283ZPPROSITE-ProRule annotationAdd BLAST265

Domaini

Zona pellucida domain may enable to form filaments.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJKZ Eukaryota
ENOG410XSHJ LUCA
GeneTreeiENSGT00530000063315
HOGENOMiHOG000124070
HOVERGENiHBG056825
InParanoidiO08524
PhylomeDBiO08524
TreeFamiTF330284

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O08524-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVRAFVLLA LFAEASAKSC TPNKADVILV FCYPKTIITK IPECPYGWEV
60 70 80 90 100
HQLALGGLCY NGVHEGGYYQ FVIPDLSPKN KSYCGTQSEY KPPIYHFYSH
110 120 130 140 150
IVSNDSTVIV KNQPVNYSFS CTYHSTYLVN QAAFDQRVAT VHVKNGSMGT
160 170 180 190 200
FESQLSLNFY TNAKFSTKKE APFVLETSEI GSDLFAGVEA KGLSVRFKVV
210 220 230 240 250
LNSCWATPSA DFMYPLQWQL INKGCPTDET VLVHENGKDH RATFQFNAFR
260 270 280 290 300
FQNIPKLSKV WLHCETFICD SEKLSCPVNC DKRKRMLRDQ TGGVLVVELS
310 320
LRSRAFSGLC DFSDVLLHLI LMLGTWAVL
Length:329
Mass (Da):36,986
Last modified:October 1, 2000 - v2
Checksum:iCC69A33EBC270AB3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3Y6D3Z3Y6_MOUSE
Beta-tectorin
Tectb
339Annotation score:
D3Z273D3Z273_MOUSE
Beta-tectorin
Tectb
195Annotation score:
F6Z818F6Z818_MOUSE
Beta-tectorin
Tectb
177Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99806 mRNA Translation: CAA68139.2
CCDSiCCDS29907.1
RefSeqiNP_033374.2, NM_009348.3
XP_006526966.1, XM_006526903.1
UniGeneiMm.42139

Genome annotation databases

EnsembliENSMUST00000025936; ENSMUSP00000025936; ENSMUSG00000024979
GeneIDi21684
KEGGimmu:21684
UCSCiuc008hxm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99806 mRNA Translation: CAA68139.2
CCDSiCCDS29907.1
RefSeqiNP_033374.2, NM_009348.3
XP_006526966.1, XM_006526903.1
UniGeneiMm.42139

3D structure databases

ProteinModelPortaliO08524
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025936

Proteomic databases

PaxDbiO08524
PRIDEiO08524

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025936; ENSMUSP00000025936; ENSMUSG00000024979
GeneIDi21684
KEGGimmu:21684
UCSCiuc008hxm.1 mouse

Organism-specific databases

CTDi6975
MGIiMGI:109574 Tectb

Phylogenomic databases

eggNOGiENOG410IJKZ Eukaryota
ENOG410XSHJ LUCA
GeneTreeiENSGT00530000063315
HOGENOMiHOG000124070
HOVERGENiHBG056825
InParanoidiO08524
PhylomeDBiO08524
TreeFamiTF330284

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

PROiPR:O08524
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024979 Expressed in 33 organ(s), highest expression level in epithelium of cochlear duct
CleanExiMM_TECTB
ExpressionAtlasiO08524 baseline and differential
GenevisibleiO08524 MM

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTECTB_MOUSE
AccessioniPrimary (citable) accession number: O08524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again