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Protein

Alpha-tectorin

Gene

Tecta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: MGI

GO - Biological processi

  • cell-matrix adhesion Source: InterPro
  • sensory perception of sound Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-tectorin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tecta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109575 Tecta

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004173725 – 2091Alpha-tectorinAdd BLAST2067
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000417382092 – 2155Removed in mature formSequence analysisAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi506N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi843N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi949N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1064N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1565N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1717 ↔ 1775By similarity
Disulfide bondi1741 ↔ 1784By similarity
Glycosylationi1756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1772N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1786 ↔ 1818By similarity
Glycosylationi1794N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1806 ↔ 1898By similarity
Disulfide bondi1837 ↔ 1857By similarity
Glycosylationi1851N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1864N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1880N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1939N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1980 ↔ 2040PROSITE-ProRule annotation
Disulfide bondi2001 ↔ 2056By similarity
Disulfide bondi2045 ↔ 2052By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2091GPI-anchor amidated asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

3 products of tectorin seem to exist: HMM, MMM and LMM. They may be generated by active processing or the result of proteolysis occurring between intrachain disulfide bonds.
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O08523

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08523

PRoteomics IDEntifications database

More...
PRIDEi
O08523

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08523

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cochlea-specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037705 Expressed in 50 organ(s), highest expression level in epithelium of cochlear duct

CleanEx database of gene expression profiles

More...
CleanExi
MM_TECTA

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O08523 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16 (By similarity).By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O08523, 1 interactor

Molecular INTeraction database

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MINTi
O08523

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000040262

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O08523

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O08523

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 252NIDOPROSITE-ProRule annotationAdd BLAST155
Domaini260 – 314VWFCAdd BLAST55
Domaini321 – 540VWFD 1PROSITE-ProRule annotationAdd BLAST220
Domaini597 – 650TIL 1Add BLAST54
Domaini712 – 929VWFD 2PROSITE-ProRule annotationAdd BLAST218
Domaini984 – 1036TIL 2Add BLAST53
Domaini1099 – 1317VWFD 3PROSITE-ProRule annotationAdd BLAST219
Domaini1372 – 1425TIL 3Add BLAST54
Domaini1486 – 1694VWFD 4PROSITE-ProRule annotationAdd BLAST209
Domaini1805 – 2059ZPPROSITE-ProRule annotationAdd BLAST255

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Zona pellucida domain may enable to form filaments.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1216 Eukaryota
KOG4291 Eukaryota
ENOG410YR2E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154874

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168220

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079244

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O08523

KEGG Orthology (KO)

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KOi
K18273

Identification of Orthologs from Complete Genome Data

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OMAi
SCNELQY

Database of Orthologous Groups

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OrthoDBi
22053at2759

TreeFam database of animal gene trees

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TreeFami
TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003886 NIDO_dom
IPR036084 Ser_inhib-like_sf
IPR033026 TECTA
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR001507 ZP_dom
IPR017977 ZP_dom_CS

The PANTHER Classification System

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PANTHERi
PTHR11339:SF235 PTHR11339:SF235, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF06119 NIDO, 1 hit
PF01826 TIL, 3 hits
PF12714 TILa, 2 hits
PF00094 VWD, 4 hits
PF00100 Zona_pellucida, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00539 NIDO, 1 hit
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SM00241 ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51220 NIDO, 1 hit
PS51233 VWFD, 4 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O08523-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYSSLLRIW VSFIFALVRH QAQPRELMYP FWQNDTRTPK VDDGSSSEIK
60 70 80 90 100
LAIPVFFFGV PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFIAPFW
110 120 130 140 150
ADVHNGIRGE IYYRETMDPA ILRRATKDIR KYFKDMTTFS ATWVFIVTWE
160 170 180 190 200
EVTFYGGSST TPVNTFQAVL VSDGSYTFTL FNYYEINWTT GTASGGDPLT
210 220 230 240 250
GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN VPGRWAFKVD
260 270 280 290 300
GKEIDPANGC TSRGQFLRRG EVFWDDLNCT IKCRCLDFNN EIYCQEASCS
310 320 330 340 350
PYEVCEPKGR FFYCSPVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR
360 370 380 390 400
QCLQTSSLPF FSVEAKNEHR GGSAVSWVKE LSVEVNGYKI LIPKGSYGKV
410 420 430 440 450
KVNDLVTSLP VTLELGAVKI YQSGMSTAVE TDFGLLVTFD GQHYASISIP
460 470 480 490 500
GSYINSTCGL CGNYNKNPLD DFLRPDGRPA MSVLDLGESW RVYHADWKCG
510 520 530 540 550
SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV VDATAFVHSC
560 570 580 590 600
VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRIQTG CVSTVRCPSF
610 620 630 640 650
SHYSVCTSSC PDTCSDLTAS QNCATPCTEG CECNEGFVLS TSQCVPLHKC
660 670 680 690 700
GCDFDGHYYT MGEFFWATAN CTVQCLCEEG GDVYCFNKTC RSGEVCAVED
710 720 730 740 750
GYQGCFPKRE TVCLLSQNQV LHTFDGAAYA FPSELSYTLL KTCPERPEYL
760 770 780 790 800
EIDINKKKPD AGPAWLRGVR ILVADQEVKI GGVGALEVKL NGQDVELPFF
810 820 830 840 850
HPSGRLEIHR NKNSTTVESK GVVSVQYSDV GLLYIRLSTM YFNCTGGLCG
860 870 880 890 900
FFNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS
910 920 930 940 950
ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE
960 970 980 990 1000
SELCDSVARY ASACKNADVE VGPWRTYDFC PLECPENSHF EECMTCTETC
1010 1020 1030 1040 1050
ETLALGPICV DSCSEGCQCD EGYALQGSQC VPRSECGCNF EGHQLATNET
1060 1070 1080 1090 1100
FWVDQDCQIF CYCNGTDNSV HCETIPCRDD EYCMEESGLY YCQPRTDASC
1110 1120 1130 1140 1150
IVSGYGHYLT FDGYPFDFQT SCPLILCTTG SRPISDSFPK FIVTAKNEDR
1160 1170 1180 1190 1200
DPSLALWVKQ VDVNVFGYSI VIHRAYKHTV LVNNERLYLP LKLGQGKINI
1210 1220 1230 1240 1250
FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNGTYGL CGRYNGNPDD
1260 1270 1280 1290 1300
DLEMPMGLPA LSINEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL
1310 1320 1330 1340 1350
CSLIPNQNAG FAKCHSKVNP TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS
1360 1370 1380 1390 1400
TCQTQGIAVT GWRNYTSCSV TCPPNSHYES CVSVCQPRCA AIRLKSDCNH
1410 1420 1430 1440 1450
YCVEGCQCDA GYVLNGKSCI LPHNCGCYSD GKYYEPKQLF WNGDCTRRCR
1460 1470 1480 1490 1500
CFRRNLIQCD PRQCKSDEEC ALRSGVRGCF STKTSYCLAA GGGVFRTFDG
1510 1520 1530 1540 1550
AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSSPNLT IISPVYFYIN
1560 1570 1580 1590 1600
EEQILINDRN TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY
1610 1620 1630 1640 1650
NGFNVIKISI SERLQNKVCG LCGNFNGDMT DDYVTLRGKP VVSSVVLAQS
1660 1670 1680 1690 1700
WKTNGMQKRP LAPSCNELQF SQYAATCDNV HIQAMQGDGY CLKLTDMKGF
1710 1720 1730 1740 1750
FQPCYGLLDP LPFYESCYLD GCYNHKKFQL CGSLAAYGEA CRSFGILSTE
1760 1770 1780 1790 1800
WIEKENCSGV VEDPCVGADC PNRTCELDNG GELCGCIEPP PYGNNSHDII
1810 1820 1830 1840 1850
DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCSGI EGEDFISFQI
1860 1870 1880 1890 1900
NNTKGNCGNI VQSNGTHIMY KNTIWIESAN NTGNIITRDR TINVEFSCAY
1910 1920 1930 1940 1950
ELDIKISLDS VVKPMLSVIN LTVPTQEGSF TTKMALYKNA SYKHPYRQGE
1960 1970 1980 1990 2000
VVLTTRDVLY VGVFVVGADS THLILTLNKC YATPSRDSND KLRYFIIEGG
2010 2020 2030 2040 2050
CQNIKDNTIG IEENGVSLTC RFHVTVFKFI GDYDEVHLHC AVSLCDSEKY
2060 2070 2080 2090 2100
SCKINCPQNS RIATDYSKEH KEQIISVGPI RRKRLDWCED NGGCEQICTS
2110 2120 2130 2140 2150
RVDGPLCSCV TGSLQEDGRS CRASNSSVEL QVWTLLLIMT QISLWHLIYK

SGATS
Length:2,155
Mass (Da):239,433
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F93E76E0FFB2C23
GO
Isoform 2 (identifier: O08523-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1659-1663: Missing.

Show »
Length:2,150
Mass (Da):238,898
Checksum:iB80D56156F66FA75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti803S → T in CAA68138 (PubMed:9079715).Curated1
Sequence conflicti1024A → R in CAA68138 (PubMed:9079715).Curated1
Sequence conflicti1032P → T in CAA68138 (PubMed:9079715).Curated1
Sequence conflicti1229V → I in CAA68138 (PubMed:9079715).Curated1
Sequence conflicti2148I → V in CAA68138 (PubMed:9079715).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0105571659 – 1663Missing in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X99805 mRNA Translation: CAA68138.1
AC156631 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS23087.1 [O08523-1]
CCDS85660.1 [O08523-2]

Protein sequence database of the Protein Information Resource

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PIRi
T30197

NCBI Reference Sequences

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RefSeqi
NP_001311477.1, NM_001324548.1 [O08523-2]
NP_033373.2, NM_009347.3 [O08523-1]
XP_017168765.1, XM_017313276.1 [O08523-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.42209

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000042190; ENSMUSP00000040262; ENSMUSG00000037705 [O08523-1]
ENSMUST00000160940; ENSMUSP00000125370; ENSMUSG00000037705 [O08523-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21683

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21683

UCSC genome browser

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UCSCi
uc009pau.1 mouse [O08523-1]
uc012grn.1 mouse [O08523-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99805 mRNA Translation: CAA68138.1
AC156631 Genomic DNA No translation available.
CCDSiCCDS23087.1 [O08523-1]
CCDS85660.1 [O08523-2]
PIRiT30197
RefSeqiNP_001311477.1, NM_001324548.1 [O08523-2]
NP_033373.2, NM_009347.3 [O08523-1]
XP_017168765.1, XM_017313276.1 [O08523-1]
UniGeneiMm.42209

3D structure databases

ProteinModelPortaliO08523
SMRiO08523
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08523, 1 interactor
MINTiO08523
STRINGi10090.ENSMUSP00000040262

PTM databases

PhosphoSitePlusiO08523

Proteomic databases

MaxQBiO08523
PaxDbiO08523
PRIDEiO08523

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042190; ENSMUSP00000040262; ENSMUSG00000037705 [O08523-1]
ENSMUST00000160940; ENSMUSP00000125370; ENSMUSG00000037705 [O08523-2]
GeneIDi21683
KEGGimmu:21683
UCSCiuc009pau.1 mouse [O08523-1]
uc012grn.1 mouse [O08523-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7007
MGIiMGI:109575 Tecta

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
KOG4291 Eukaryota
ENOG410YR2E LUCA
GeneTreeiENSGT00940000154874
HOGENOMiHOG000168220
HOVERGENiHBG079244
InParanoidiO08523
KOiK18273
OMAiSCNELQY
OrthoDBi22053at2759
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

Protein Ontology

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PROi
PR:O08523

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037705 Expressed in 50 organ(s), highest expression level in epithelium of cochlear duct
CleanExiMM_TECTA
GenevisibleiO08523 MM

Family and domain databases

InterProiView protein in InterPro
IPR003886 NIDO_dom
IPR036084 Ser_inhib-like_sf
IPR033026 TECTA
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PANTHERiPTHR11339:SF235 PTHR11339:SF235, 1 hit
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF06119 NIDO, 1 hit
PF01826 TIL, 3 hits
PF12714 TILa, 2 hits
PF00094 VWD, 4 hits
PF00100 Zona_pellucida, 1 hit
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00539 NIDO, 1 hit
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SM00241 ZP, 1 hit
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51220 NIDO, 1 hit
PS51233 VWFD, 4 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTECTA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08523
Secondary accession number(s): E9QNR3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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