UniProtKB - O08522 (GOSR1_CRIGR)
Golgi SNAP receptor complex member 1
GOSR1
Functioni
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
1 PublicationCaution
GO - Molecular functioni
- SNAP receptor activity Source: UniProtKB
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- intra-Golgi vesicle-mediated transport Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi SNAP receptor complex member 1Alternative name(s): 28 kDa Golgi SNARE protein 28 kDa cis-Golgi SNARE p28 Short name: GOS-28 |
Gene namesi | Name:GOSR1 Synonyms:GS28 |
Organismi | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) |
Taxonomic identifieri | 10029 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Cricetidae › Cricetinae › Cricetulus |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Single-pass type IV membrane protein 1 Publication
Note: Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi (By similarity).By similarity
Golgi apparatus
- cis-Golgi network Source: InterPro
- Golgi membrane Source: UniProtKB-SubCell
- Golgi trans cisterna Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 229 | CytoplasmicSequence analysisAdd BLAST | 228 | |
Transmembranei | 230 – 250 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000212541 | 2 – 250 | Golgi SNAP receptor complex member 1Add BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 141 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Component of several multiprotein Golgi SNARE complexes.
Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3.
Interacts with GABARAPL2 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10029.NP_001233674.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 38 – 59 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 9 – 30 | Sequence analysisAdd BLAST | 22 | |
Coiled coili | 68 – 95 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3208, Eukaryota |
GeneTreei | ENSGT00390000008688 |
OMAi | QAYAVND |
OrthoDBi | 1319902at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR023601, Golgi_SNAP_su1 |
PANTHERi | PTHR21094, PTHR21094, 1 hit |
PIRSFi | PIRSF027109, Golgi_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAAGTSNYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS SARDGGRDRY
60 70 80 90 100
SSDTTPLLNG SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTNSAGVPSL
110 120 130 140 150
NAALMHTLQR HRDILQDYTH EFHKTKANFM AIRERENLMG SVRKDIESYK
160 170 180 190 200
SGSGVNNRRT ELFLKEHDHL RNSDRLIEET ISIAMATKEN MTSQRGMLKS
210 220 230 240 250
IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49841 mRNA Translation: AAB51019.1 |
RefSeqi | NP_001233674.1, NM_001246745.1 |
Genome annotation databases
Ensembli | ENSCGRT00001017728; ENSCGRP00001013491; ENSCGRG00001014609 |
GeneIDi | 100689312 |
KEGGi | cge:100689312 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U49841 mRNA Translation: AAB51019.1 |
RefSeqi | NP_001233674.1, NM_001246745.1 |
3D structure databases
SMRi | O08522 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10029.NP_001233674.1 |
Genome annotation databases
Ensembli | ENSCGRT00001017728; ENSCGRP00001013491; ENSCGRG00001014609 |
GeneIDi | 100689312 |
KEGGi | cge:100689312 |
Organism-specific databases
CTDi | 9527 |
Phylogenomic databases
eggNOGi | KOG3208, Eukaryota |
GeneTreei | ENSGT00390000008688 |
OMAi | QAYAVND |
OrthoDBi | 1319902at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR023601, Golgi_SNAP_su1 |
PANTHERi | PTHR21094, PTHR21094, 1 hit |
PIRSFi | PIRSF027109, Golgi_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GOSR1_CRIGR | |
Accessioni | O08522Primary (citable) accession number: O08522 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | July 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families