UniProtKB - O07779 (VPB27_MYCTU)
Protein
Antitoxin VapB27
Gene
vapB27
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Antitoxin component of a type II toxin-antitoxin (TA) system. Cognate toxin is VapC27. Upon expression in E.coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Toxin-antitoxin system |
Names & Taxonomyi
Protein namesi | Recommended name: Antitoxin VapB27 |
Gene namesi | Name:vapB27 Synonyms:vapB-mt24 Ordered Locus Names:Rv0599c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0599c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000408044 | 1 – 78 | Antitoxin VapB27Add BLAST | 78 |
Proteomic databases
PaxDbi | O07779 |
Interactioni
Subunit structurei
Interacts with cognate toxin VapC27 and non-cognate toxins MazF6 and VapC40. Interaction with MazF6 and MazF9 partially neutralizes the toxins.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv0599c |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 45 | SpoVT-AbrBPROSITE-ProRule annotationAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the VapB family.Curated
Phylogenomic databases
eggNOGi | COG2002, Bacteria |
InParanoidi | O07779 |
OMAi | TDEMMFA |
PhylomeDBi | O07779 |
Family and domain databases
InterProi | View protein in InterPro IPR007159, SpoVT-AbrB_dom IPR037914, SpoVT-AbrB_sf |
Pfami | View protein in Pfam PF04014, MazE_antitoxin, 1 hit |
SMARTi | View protein in SMART SM00966, SpoVT_AbrB, 1 hit |
SUPFAMi | SSF89447, SSF89447, 1 hit |
TIGRFAMsi | TIGR01439, lp_hng_hel_AbrB, 1 hit |
PROSITEi | View protein in PROSITE PS51740, SPOVT_ABRB, 1 hit |
i Sequence
Sequence statusi: Complete.
O07779-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAVVDAAGR IVVPKPLREA LGLQPGSTVE ISRYGAGLHL IPTGRTARLE
60 70
EENGVLVATG ETTIDDEVVF GLIDSGRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43338.1 |
PIRi | B70909 |
RefSeqi | NP_215113.1, NC_000962.3 WP_003403139.1, NZ_NVQJ01000033.1 |
Genome annotation databases
EnsemblBacteriai | CCP43338; CCP43338; Rv0599c |
GeneIDi | 23493301 887856 |
KEGGi | mtu:Rv0599c mtv:RVBD_0599c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43338.1 |
PIRi | B70909 |
RefSeqi | NP_215113.1, NC_000962.3 WP_003403139.1, NZ_NVQJ01000033.1 |
3D structure databases
SMRi | O07779 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0599c |
Proteomic databases
PaxDbi | O07779 |
Genome annotation databases
EnsemblBacteriai | CCP43338; CCP43338; Rv0599c |
GeneIDi | 23493301 887856 |
KEGGi | mtu:Rv0599c mtv:RVBD_0599c |
Organism-specific databases
TubercuListi | Rv0599c |
Phylogenomic databases
eggNOGi | COG2002, Bacteria |
InParanoidi | O07779 |
OMAi | TDEMMFA |
PhylomeDBi | O07779 |
Family and domain databases
InterProi | View protein in InterPro IPR007159, SpoVT-AbrB_dom IPR037914, SpoVT-AbrB_sf |
Pfami | View protein in Pfam PF04014, MazE_antitoxin, 1 hit |
SMARTi | View protein in SMART SM00966, SpoVT_AbrB, 1 hit |
SUPFAMi | SSF89447, SSF89447, 1 hit |
TIGRFAMsi | TIGR01439, lp_hng_hel_AbrB, 1 hit |
PROSITEi | View protein in PROSITE PS51740, SPOVT_ABRB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPB27_MYCTU | |
Accessioni | O07779Primary (citable) accession number: O07779 Secondary accession number(s): L0T6Z9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 3, 2011 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 7, 2020 | |
This is version 94 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families