Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable zinc-binding alcohol dehydrogenase Rv1895

Gene

Rv1895

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi59Zinc 1; catalyticBy similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable zinc-binding alcohol dehydrogenase Rv1895 (EC:1.1.1.1)
Gene namesi
Ordered Locus Names:Rv1895
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1895

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004155041 – 384Probable zinc-binding alcohol dehydrogenase Rv1895Add BLAST384

Proteomic databases

PaxDbiO07737
PRIDEiO07737

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1895

Structurei

3D structure databases

ProteinModelPortaliO07737
SMRiO07737
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E2A Bacteria
COG1063 LUCA
HOGENOMiHOG000294694
InParanoidiO07737
OMAiIAGPNEK
PhylomeDBiO07737

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

O07737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVVIDGAG SVRVNTQPDP ALPGPDGVVV AVTAAGICGS DLHFYEGEYP
60 70 80 90 100
FTEPVALGHE AVGTIVEAGP QVRTVGVGDL VMVSSVAGCG VCPGCETHDP
110 120 130 140 150
VMCFSGPMIF GAGVLGGAQA DLLAVPAADF QVLKIPEGIT TEQALLLTDN
160 170 180 190 200
LATGWAAAQR ADISFGSAVA VIGLGAVGLC ALRSAFIHGA ATVFAVDRVK
210 220 230 240 250
GRLQRAATWG ATPIPSPAAE TILAATRGRG ADSVIDAVGT DASMSDALNA
260 270 280 290 300
VRPGGTVSVV GVHDLQPFPV PALTCLLRSI TLRMTMAPVQ RTWPELIPLL
310 320 330 340 350
QSGRLDVDGI FTTTLPLDEA AKGYATARAR SGEELRFCLR PDSRDVLGAH
360 370 380
ETVDLYVHVR RCQSVADLQL EGAADGVDGP SMLN
Length:384
Mass (Da):39,479
Last modified:July 1, 1997 - v1
Checksum:iDAD02DD880B3131A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44662.1
PIRiD70517
RefSeqiNP_216411.1, NC_000962.3
WP_003911674.1, NC_000962.3

Genome annotation databases

EnsemblBacteriaiCCP44662; CCP44662; Rv1895
GeneIDi885148
KEGGimtu:Rv1895
mtv:RVBD_1895
PATRICifig|83332.111.peg.2109

Similar proteinsi

Entry informationi

Entry nameiY1895_MYCTU
AccessioniPrimary (citable) accession number: O07737
Secondary accession number(s): L0T807
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health