UniProtKB - O07550 (YHEI_BACSU)
Protein
Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI
Gene
yheI
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation.1 Publication
Miscellaneous
Overexpression reduces the sporulation efficiency possibly by modulating the function of KinA.
Activity regulationi
Inhibited by ortho-vanadate.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 371 – 378 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Antibiotic resistance, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU09710-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.106.8, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (EC:7.6.2.-) |
Gene namesi | Name:yheI Ordered Locus Names:BSU09710 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
- Cell membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 57 – 77 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 127 – 147 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 249 – 269 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 279 – 299 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376079 | 1 – 585 | Probable multidrug resistance ABC transporter ATP-binding/permease protein YheIAdd BLAST | 585 |
Proteomic databases
PaxDbi | O07550 |
PRIDEi | O07550 |
Expressioni
Inductioni
Induced by several classes of structurally unrelated antibiotics, such as erythromycin, fusidic acid or linezolid.1 Publication
Interactioni
Subunit structurei
Heterodimer composed of YheH and YheI.
1 PublicationProtein-protein interaction databases
STRINGi | 224308.BSU09710 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 304 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 286 | |
Domaini | 337 – 572 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 236 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1132, Bacteria |
InParanoidi | O07550 |
OMAi | TITAYQR |
PhylomeDBi | O07550 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O07550-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSVLKKLGW FFKAYWLRYT IAIVLLLAVN VIEMFPPKLL GNAIDDMKAG
60 70 80 90 100
AFTAEGLLFY IGIFFVLTAA VYIMSYFWMH QLFGGANLME KILRTKLMGH
110 120 130 140 150
LLTMSPPFYE KNRTGDLMAR GTNDLQAVSL TTGFGILTLV DSTMFMMTIF
160 170 180 190 200
LTMGFLISWK LTFAAIIPLP VMAIAISLYG SKIHERFTEA QNAFGALNDR
210 220 230 240 250
VLESVSGVRV IRAYVQETND VRRFNEMTAD VYQKNMKVAF IDSLFEPTVK
260 270 280 290 300
LLVGASYLIG LGYGAFLVFR NELTLGELVS FNVYLGMMIW PMFAIGELIN
310 320 330 340 350
VMQRGNASLD RVNETLSYET DVTDPKQPAD LKEPGDIVFS HVSFTYPSST
360 370 380 390 400
SDNLQDISFT VRKGQTVGIA GKTGSGKTTI IKQLLRQYPP GEGSITFSGV
410 420 430 440 450
PIQQIPLDRL RGWIGYVPQD HLLFSRTVKE NILYGKQDAT DKEVQQAIAE
460 470 480 490 500
AHFEKDLHML PSGLETMVGE KGVALSGGQK QRISIARALM ANPEILILDD
510 520 530 540 550
SLSAVDAKTE AAIIKNIREN RKGKTTFILT HRLSAVEHAD LILVMDGGVI
560 570 580
AERGTHQELL ANNGWYREQY ERQQLFTAEE GGAGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14080 Genomic DNA Translation: CAA74450.1 AL009126 Genomic DNA Translation: CAB12810.1 |
PIRi | A69829 |
RefSeqi | NP_388852.1, NC_000964.3 WP_003245157.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB12810; CAB12810; BSU09710 |
GeneIDi | 936278 |
KEGGi | bsu:BSU09710 |
PATRICi | fig|224308.179.peg.1044 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14080 Genomic DNA Translation: CAA74450.1 AL009126 Genomic DNA Translation: CAB12810.1 |
PIRi | A69829 |
RefSeqi | NP_388852.1, NC_000964.3 WP_003245157.1, NZ_JNCM01000035.1 |
3D structure databases
SMRi | O07550 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU09710 |
Protein family/group databases
TCDBi | 3.A.1.106.8, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | O07550 |
PRIDEi | O07550 |
Genome annotation databases
EnsemblBacteriai | CAB12810; CAB12810; BSU09710 |
GeneIDi | 936278 |
KEGGi | bsu:BSU09710 |
PATRICi | fig|224308.179.peg.1044 |
Phylogenomic databases
eggNOGi | COG1132, Bacteria |
InParanoidi | O07550 |
OMAi | TITAYQR |
PhylomeDBi | O07550 |
Enzyme and pathway databases
BioCyci | BSUB:BSU09710-MONOMER |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YHEI_BACSU | |
Accessioni | O07550Primary (citable) accession number: O07550 Secondary accession number(s): Q796W6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families