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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Methylobacillus flagellatus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. no protein annotated in this organism
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisC
Synonyms:hisH
OrganismiMethylobacillus flagellatus
Taxonomic identifieri405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesMethylophilaceaeMethylobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001533901 – 368Histidinol-phosphate aminotransferaseAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO07131
SMRiO07131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

O07131-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRLYDFAPS NIRAIAPYQP GKPITELARE MGLKPGVIIK LASNENPLGV
60 70 80 90 100
SPKAYAAMQD ALEDIARYPD GNSFALRDCV CRKFKLQPDQ LVFGNGSNDI
110 120 130 140 150
LELAARAFLT PGTEAVYAQH AFAVYALVTQ ATGASGISVP ARDFGHDLDA
160 170 180 190 200
MLAAITDKTR LFIANPNNPT GTLLSKPALR DFLAKVPRQV LVVLDEAYDE
210 220 230 240 250
YLAAELKSEA FSWLAEFDNL LISRTLSKAY GLAGLRVGFG VTSPGVADLM
260 270 280 290 300
NRVRQPFNVN SVAQAAAVAA LEDDEFVERS YALNQAGMQQ LTEGLARLGL
310 320 330 340 350
SYIPSYGNFV SFHVAQAAEV YQQLLKRGVI VRPVAAYDMP DYLRVSIGLH
360
AENARFLEVL EQILKTRT
Length:368
Mass (Da):40,134
Last modified:July 1, 1997 - v1
Checksum:iC8F47963A732B3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83322 Genomic DNA Translation: AAB58526.1

Similar proteinsi

Entry informationi

Entry nameiHIS8_METFL
AccessioniPrimary (citable) accession number: O07131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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