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Protein

Probable phosphoadenosine phosphosulfate reductase

Gene

yitB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.By similarity

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Probable sulfate adenylyltransferase (yitA), Sulfate adenylyltransferase (sat)
  2. Probable adenylyl-sulfate kinase (yisZ), Probable adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH), Probable phosphoadenosine phosphosulfate reductase (yitB)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

  • phosphoadenylyl-sulfate reductase (thioredoxin) activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciBSUB:BSU10930-MONOMER
UniPathwayi
UPA00140;UER00206

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoadenosine phosphosulfate reductase (EC:1.8.4.8)
Alternative name(s):
3'-phosphoadenylylsulfate reductase
PAPS reductase, thioredoxin dependent
PAPS sulfotransferase
PAdoPS reductase
Gene namesi
Name:yitB
Ordered Locus Names:BSU10930
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001006271 – 236Probable phosphoadenosine phosphosulfate reductaseAdd BLAST236

Proteomic databases

PaxDbiO06737
PRIDEiO06737

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100006036

Structurei

3D structure databases

ProteinModelPortaliO06737
SMRiO06737
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105ET3 Bacteria
COG0175 LUCA
HOGENOMiHOG000249397
InParanoidiO06737
KOiK00390
OMAiKTECGLW
PhylomeDBiO06737

Family and domain databases

CDDicd01713 PAPS_reductase, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00063 CysH, 1 hit
InterProiView protein in InterPro
IPR011798 APS_reductase
IPR004511 PAPS/APS_Rdtase
IPR002500 PAPS_reduct
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01507 PAPS_reduct, 1 hit
PIRSFiPIRSF000857 PAPS_reductase, 1 hit
TIGRFAMsiTIGR02055 APS_reductase, 1 hit
TIGR00434 cysH, 1 hit

Sequencei

Sequence statusi: Complete.

O06737-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNETITYDTW NDMLSKQITD QLIDELDVLK WAYRTYGEKI VYACSFGAEG
60 70 80 90 100
MVLLDLISKI NKNAHIIFLD TGLHFQETYE LIETVKERYP GFAIQMLEPE
110 120 130 140 150
LSLTEQGTKY GGELWKHNPN LCCQLRKIEP LKKHLSGMTA WISGLRRDQS
160 170 180 190 200
PTRKHIQYVN LDQKFELIKI CPLIHWTWDD VWTYIRLHNL PYNKLHDQHY
210 220 230
PSIGCEMCTL PSPDPNDERA GRWAGREKTE CGLHQE
Length:236
Mass (Da):27,671
Last modified:May 30, 2000 - v2
Checksum:i83B792372CC431C6
GO

Sequence cautioni

The sequence CAA70657 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09476 Genomic DNA Translation: CAA70657.1 Different initiation.
AL009126 Genomic DNA Translation: CAB12933.2
PIRiC69839
RefSeqiNP_388974.2, NC_000964.3
WP_003244757.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB12933; CAB12933; BSU10930
GeneIDi939787
KEGGibsu:BSU10930
PATRICifig|224308.179.peg.1175

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09476 Genomic DNA Translation: CAA70657.1 Different initiation.
AL009126 Genomic DNA Translation: CAB12933.2
PIRiC69839
RefSeqiNP_388974.2, NC_000964.3
WP_003244757.1, NZ_JNCM01000035.1

3D structure databases

ProteinModelPortaliO06737
SMRiO06737
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100006036

Proteomic databases

PaxDbiO06737
PRIDEiO06737

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12933; CAB12933; BSU10930
GeneIDi939787
KEGGibsu:BSU10930
PATRICifig|224308.179.peg.1175

Phylogenomic databases

eggNOGiENOG4105ET3 Bacteria
COG0175 LUCA
HOGENOMiHOG000249397
InParanoidiO06737
KOiK00390
OMAiKTECGLW
PhylomeDBiO06737

Enzyme and pathway databases

UniPathwayi
UPA00140;UER00206

BioCyciBSUB:BSU10930-MONOMER

Family and domain databases

CDDicd01713 PAPS_reductase, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00063 CysH, 1 hit
InterProiView protein in InterPro
IPR011798 APS_reductase
IPR004511 PAPS/APS_Rdtase
IPR002500 PAPS_reduct
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01507 PAPS_reduct, 1 hit
PIRSFiPIRSF000857 PAPS_reductase, 1 hit
TIGRFAMsiTIGR02055 APS_reductase, 1 hit
TIGR00434 cysH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYSH2_BACSU
AccessioniPrimary (citable) accession number: O06737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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Main funding by: National Institutes of Health

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