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Protein

Trehalose synthase

Gene

treS

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of maltose and alpha,alpha-trehalose by transglucosylation.By similarity

Catalytic activityi

Maltose = alpha,alpha-trehalose.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateBy similarity1
Metal bindingi100CalciumBy similarity1
Binding sitei101SubstrateBy similarity1
Binding sitei165SubstrateBy similarity1
Metal bindingi167CalciumBy similarity1
Binding sitei195SubstrateBy similarity1
Active sitei197NucleophileBy similarity1
Metal bindingi201Calcium; via carbonyl oxygenBy similarity1
Metal bindingi202Calcium; via carbonyl oxygenBy similarity1
Metal bindingi204CalciumBy similarity1
Active sitei240Proton donorBy similarity1
Binding sitei305SubstrateBy similarity1
Binding sitei306SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandCalcium, Metal-binding

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose synthase (EC:5.4.99.16By similarity)
Alternative name(s):
Maltose alpha-D-glucosyltransferase
Gene namesi
Name:treS
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000543441 – 963Trehalose synthaseAdd BLAST963

Proteomic databases

PRIDEiO06458

Structurei

3D structure databases

ProteinModelPortaliO06458
SMRiO06458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CG3 Bacteria
COG0366 LUCA

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR032091 Malt_amylase_C
IPR012810 TreS/a-amylase_N
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
PF16657 Malt_amylase_C, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR02456 treS_nterm, 1 hit

Sequencei

Sequence statusi: Complete.

O06458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLWYKDAV IYQLHVRSFF DANNDGYGDF EGLRRKLPYL EELGVNTLWL
60 70 80 90 100
MPFFQSPLRD DGYDISDYYQ ILPVHGTLED FTVDEAHGRG MKVIIELVLN
110 120 130 140 150
HTSIDHPWFQ EARKPNSPMR DWYVWSDTPE KYKGVRVIFK DFETSNWTFD
160 170 180 190 200
PVAKAYYWHR FYWHQPDLNW DSPEVEKAIH QVMFFWADLG VDGFRLDAIP
210 220 230 240 250
YLYEREGTSC ENLPETIEAV KRLRKALEER YGPGKILLAE VNMWPEETLP
260 270 280 290 300
YFGDGDGVHM AYNFPLMPRI FMALRREDRG PIETMLKEAE GIPETAQWAL
310 320 330 340 350
FLRNHDELTL EKVTEEEREF MYEAYAPDPK FRINLGIRRR LMPLLGGDRR
360 370 380 390 400
RYELLTALLL TLKGTPIVYY GDEIGMGDNP FLGDRNGVRT PMQWSQDRIV
410 420 430 440 450
AFSRAPYHAL FLPPVSEGPY SYHFVNVEAQ RENPHSLLSF NRRFLALRNQ
460 470 480 490 500
HAKIFGRGSL TLLPVENRRV LAYLREHEGE RVLVVANLSR YTQAFDLPLE
510 520 530 540 550
AYQGLVPVEL FSQQPFPPVE GRYRLTLGPH GFALFALKPV EAVLHLPSPD
560 570 580 590 600
WAEEPAPEEA DLPRVHMPGG PEVLLVDTLV HERGREELLN ALAQTLKEKS
610 620 630 640 650
WLALKPQKVA LLDALRFQKD PPLYLTLLQL ENHRTLQVSL PLLWSPQRRE
660 670 680 690 700
GPGLFARTHG QPGYFYELSL DPGFYRLLLA RLKEGFEGRS LRAYYRGRHP
710 720 730 740 750
GPVPEAVDLL RPGLAAGEGV WVQLGLVQDG GLDRTERVLP RLDLPWVLRP
760 770 780 790 800
EGGLFWERGA SRRVLALTGS LPPGRPQDLF AALEVRLLES LPRLRGHAPG
810 820 830 840 850
TPGLLPGALH ETEALVRLLG VRLALLHRAL GEVEGVVGGH PLLGRGLGAF
860 870 880 890 900
LELEGEVYLV ALGAEKRGTV EEDLARLAYD VERAVHLALE ALEAELWAFA
910 920 930 940 950
EEVADHLHAA FLQAYRSALP EEALEEAGWT RHMAEVAAEH LHREERPARK
960
RIHERWQAKA GKA
Length:963
Mass (Da):110,171
Last modified:July 1, 1997 - v1
Checksum:iB6CB3CED365764AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86216 Genomic DNA Translation: BAA19934.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86216 Genomic DNA Translation: BAA19934.1

3D structure databases

ProteinModelPortaliO06458
SMRiO06458
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

Proteomic databases

PRIDEiO06458

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CG3 Bacteria
COG0366 LUCA

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR032091 Malt_amylase_C
IPR012810 TreS/a-amylase_N
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
PF16657 Malt_amylase_C, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR02456 treS_nterm, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRES_THETH
AccessioniPrimary (citable) accession number: O06458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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