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Protein

Uncharacterized RNA pseudouridine synthase ML1370

Gene

ML1370

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase ML1370 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:ML1370
ORF Names:MLCB1351.03c, u0247g
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1370

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001000281 – 256Uncharacterized RNA pseudouridine synthase ML1370Add BLAST256

Proteomic databases

PRIDEiO05668

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1370

Structurei

3D structure databases

ProteinModelPortaliO05668
SMRiO05668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 83S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated

Phylogenomic databases

eggNOGiENOG4105FE9 Bacteria
COG1187 LUCA
HOGENOMiHOG000044954
OMAiSQGFGTR
OrthoDBiPOG091H02IO

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR000748 PsdUridine_synth_RsuA/RluB/E/F
IPR018496 PsdUridine_synth_RsuA/RluB_CS
IPR006145 PsdUridine_synth_RsuA/RluD
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR21600 PTHR21600, 1 hit
PfamiView protein in Pfam
PF00849 PseudoU_synth_2, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM00363 S4, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00093 TIGR00093, 1 hit
PROSITEiView protein in PROSITE
PS01149 PSI_RSU, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

O05668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEIHDSRMD RGAGAVRLQK ILSRAGIASR RAAEKLIIEG RVEVDGQLVR
60 70 80 90 100
ELGTRVDPDV SVVRVDGVKV VVDDSLVYLA LNKPRGMYST MSDDRGRPCV
110 120 130 140 150
GDLIERRVRG NKKLFHVGRL DADTEGLILL TNDGELAHRL MHPSHEVSKT
160 170 180 190 200
YLATVKGAVP RGLGKKLSVG LELDDGPAHV DDFAVVDAIP GKTLVRLTLH
210 220 230 240 250
EGRKRIVRRL LTAAGFPVEM LVRTDIGAVS LGDQRPGCLR ALLRDEIRQL

YKEVGL
Length:256
Mass (Da):28,114
Last modified:July 1, 1997 - v1
Checksum:i686746EF490FB695
GO

Sequence cautioni

The sequence CAC31751 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95117 Genomic DNA Translation: CAB08276.1
AL583921 Genomic DNA Translation: CAC31751.1 Different initiation.
U00021 Genomic DNA Translation: AAA50926.1
PIRiD87080
S72955
RefSeqiWP_010908299.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31751; CAC31751; CAC31751

Similar proteinsi

Entry informationi

Entry nameiY1370_MYCLE
AccessioniPrimary (citable) accession number: O05668
Secondary accession number(s): Q49886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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