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Protein

Acetate kinase

Gene

ackA

Organism
Chlorante-Aster yellows phytoplasma
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Active sitei145Proton donor/acceptorUniRule annotation1
Sitei177Transition state stabilizerUniRule annotation1
Sitei236Transition state stabilizerUniRule annotation1
Metal bindingi379MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 207ATPUniRule annotation5
Nucleotide bindingi278 – 280ATPUniRule annotation3
Nucleotide bindingi326 – 330ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
OrganismiChlorante-Aster yellows phytoplasma
Taxonomic identifieri54389 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075431 – 410Acetate kinaseAdd BLAST410

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO05278
SMRiO05278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O05278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIMSVNSGS SSLKFQLLEM PQQEVIVSGL VERIGSNQAV FTMKTKDKKD
60 70 80 90 100
KQVLEVLNHQ TAVELLLDAL IQKKVINTLE EIEGVGHRVV QGGEIFSDSA
110 120 130 140 150
VLTEKTLAQI ESLCDLAPLH NPANIISIKA FQKVLPQVFQ VAVFDTTFHQ
160 170 180 190 200
SMPAVNFLYA TPYYWYQKYQ IRKYGAHGTS YKYITEQMQQ ILGKKNAKII
210 220 230 240 250
ICHAGNGVSL CAVDSGKSVD TSMGFTPLEG VPMGTRSGNI DPAVVKFIAE
260 270 280 290 300
KENKTVACVI DDLNKKSGYL GVSGISNDTR DILASIKEGN QQAILSHDIQ
310 320 330 340 350
VKRIVDYIAS YYVLLKGVDA LVFTAGIGEN SSFFRSEIIK RLSVLGIKLD
360 370 380 390 400
EEKNKVQGKQ ELITTFDSAI KAFVVPTNEE LAIAQDVLRL QQNQTNQDKD
410
DQQECFCCCG
Length:410
Mass (Da):45,313
Last modified:July 1, 1997 - v1
Checksum:i1B22784809F6C210
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77617 Genomic DNA Translation: AAB51345.1

Similar proteinsi

Entry informationi

Entry nameiACKA_CHAYP
AccessioniPrimary (citable) accession number: O05278
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: July 1, 1997
Last modified: March 15, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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