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Protein

Phospholipase D alpha 1

Gene

PLD1

Organism
Vigna unguiculata (Cowpea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes.

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei331PROSITE-ProRule annotation1
Active sitei333PROSITE-ProRule annotation1
Active sitei338PROSITE-ProRule annotation1
Active sitei660PROSITE-ProRule annotation1
Active sitei662PROSITE-ProRule annotation1
Active sitei667PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium

Enzyme and pathway databases

BRENDAi3.1.4.4 6657

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D alpha 1 (EC:3.1.4.4)
Short name:
PLD alpha 1
Alternative name(s):
Choline phosphatase 1
Phosphatidylcholine-hydrolyzing phospholipase D 1
Gene namesi
Name:PLD1
OrganismiVigna unguiculata (Cowpea)
Taxonomic identifieri3917 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeindigoferoid/millettioid cladePhaseoleaeVigna

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188241 – 809Phospholipase D alpha 1Add BLAST809

Proteomic databases

PRIDEiO04865

Structurei

3D structure databases

ProteinModelPortaliO04865
SMRiO04865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109C2Add BLAST109
Domaini326 – 365PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST40
Domaini655 – 682PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Domaini

C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. A lower affinity toward calcium can be anticipated for PLD alpha due to the absence of two potential calcium ligands.

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001736 PLipase_D/transphosphatidylase
IPR024632 PLipase_D_C
IPR015679 PLipase_D_fam
IPR011402 PLipase_D_pln
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12357 PLD_C, 1 hit
PF00614 PLDc, 2 hits
PIRSFiPIRSF036470 PLD_plant, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

O04865-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQILLHGTL HATIYEVDEL HGGGGGNFFS KLKQNIEETV GIGKGVTKLY
60 70 80 90 100
ATIDLEKARV GRTRIIENET TNPKWNESFH IYCGHLASNI IFTVKDDNPI
110 120 130 140 150
GATLIGRAYV PVSEVLDGHE IDKWVEILDT EKNPIEGGSK IHVRLQYFDV
160 170 180 190 200
LKDRNWARGI RSPKYPGVPY TFFSQRQGCK VFLYQDAHVP DNFVPKIPLA
210 220 230 240 250
GGKNYEAHRC WEDIFDAITN AKHLIYITGW SVYTEISLIR DSRRPKAGGD
260 270 280 290 300
QTIGELLKKK ASEGVRVLML VWDDRTSVGL LKKDGLMATH DEETEQFFRD
310 320 330 340 350
TDVHCVLCPR NPDDGGSIVQ DLQISTMFTH HQKIVVVDSA LPGGGGSDKR
360 370 380 390 400
RIVSFVGGLD LCDGRYDTAF HSLFRTLDTA HHDDFHQPNF PGAAITKGGP
410 420 430 440 450
REPWHDIHSR VEGPIAWDVL FNFEQRWRKQ GGKDILAPLR ELEDVIIPPS
460 470 480 490 500
PVTFPDDHET WNVQLFRSID GGAAFGFPDT PEDAAKAGLV SGKDNIIDRS
510 520 530 540 550
IQDAYIHAIR RAKNFIYIEN QYFLGSSFSW NNDDIKREEI GALHLIPKEL
560 570 580 590 600
SLKIVSKIEA GERFAVYVVV PMWPEGIPES SSVQAILDWQ KRTIEMMYKD
610 620 630 640 650
VVQALRAKGS DEDPRNYLTF FCLGNREVKK SGEYEPAEQP EPDSDYQRAQ
660 670 680 690 700
EARRFMIYVH TKMMIVDDEY IIIGSANINQ RSMDGARDSE IAMGGYQPYH
710 720 730 740 750
LANTQPARGQ VYGFRMSLWY EHLGMLHDTF QRPESEECIN KVNQIADKYW
760 770 780 790 800
DLYSSESLER DLPGHLLRYP IGVASEGEVT ELPGFEFFPD TKARILGAKA

DYLPPILTT
Length:809
Mass (Da):91,565
Last modified:July 1, 1997 - v1
Checksum:i4EFE00B634DDD946
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92656 mRNA Translation: AAB51392.1
PIRiT11695

Similar proteinsi

Entry informationi

Entry nameiPLDA1_VIGUN
AccessioniPrimary (citable) accession number: O04865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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