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Protein

Serine/threonine-protein phosphatase PP1 isozyme 1

Gene

NPP1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Manganese 1By similarity1
Metal bindingi77Manganese 1By similarity1
Metal bindingi103Manganese 1By similarity1
Metal bindingi103Manganese 2By similarity1
Metal bindingi135Manganese 2By similarity1
Active sitei136Proton donorBy similarity1
Metal bindingi184Manganese 2By similarity1
Metal bindingi259Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 1 (EC:3.1.3.16)
Gene namesi
Name:NPP1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588111 – 317Serine/threonine-protein phosphatase PP1 isozyme 1Add BLAST317

Proteomic databases

PRIDEiO04856

Structurei

3D structure databases

ProteinModelPortaliO04856
SMRiO04856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

KOiK06269

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

O04856-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQNNEQQQQ GQGLIEAGVL DDIINRLLEF RNARTVRQVQ LSEAEIRSLC
60 70 80 90 100
SASREIFLQQ PNLLDLKPPI KICGDIHGQY GDLLRLFEYG GFPPEANYLF
110 120 130 140 150
LGDYVDRGKQ SLETICLLLA YKIKYPENFF LLRGNHECAS INRIYGFYDE
160 170 180 190 200
CKRRFNVKLW KCFTECFNCL PVAALIDEKI LCMHGGLSPV LTNLDQIRNL
210 220 230 240 250
PRPTDVPDSG LLCDLLWSDP SREVKGWGMN DRGVSYTFGP DKVAEFLMQH
260 270 280 290 300
DMDLVCRAHQ VVEDGYEFFA ERQLVTIFSA PNYCGEFDNA GAMMSVDESL
310
MCSFQILKPT DRKPRFL
Length:317
Mass (Da):36,266
Last modified:July 1, 1997 - v1
Checksum:iC7613FE847CCDD36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93768 mRNA Translation: CAB07803.1
PIRiT03594
RefSeqiNP_001311560.1, NM_001324631.1
UniGeneiNta.4230

Genome annotation databases

GeneIDi107759089
KEGGinta:107759089

Similar proteinsi

Entry informationi

Entry nameiPP11_TOBAC
AccessioniPrimary (citable) accession number: O04856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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