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Entry version 128 (23 Feb 2022)
Sequence version 2 (15 May 2007)
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Protein

Putative nucleolar protein 5-3

Gene

NOP5-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for 60S ribosomal subunit biogenesis.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • snoRNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative nucleolar protein 5-3
Alternative name(s):
Nucleolar protein 58-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOP5-3
Synonyms:NOP58-3
Ordered Locus Names:At5g27140
ORF Names:T21B4_50, TM021B04.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G27140

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002190321 – 450Putative nucleolar protein 5-3Add BLAST450

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O04656

PRoteomics IDEntifications database

More...
PRIDEi
O04656

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
251070

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O04656, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O04656, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
18046, 37 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT5G27140.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O04656

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini252 – 370NopPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni375 – 423DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi381 – 423Basic and acidic residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2572, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015495_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O04656

Database of Orthologous Groups

More...
OrthoDBi
632707at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O04656

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.246.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR045056, Nop56/Nop58
IPR012974, NOP5_N
IPR042239, Nop_C
IPR002687, Nop_dom
IPR036070, Nop_dom_sf
IPR012976, NOSIC

The PANTHER Classification System

More...
PANTHERi
PTHR10894, PTHR10894, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01798, Nop, 1 hit
PF08156, NOP5NT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00931, NOSIC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89124, SSF89124, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51358, NOP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O04656-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVLFETSGG FALFKVLDEG KLSNVEDLGT EFYSAESARR MGLHKFLKNN
60 70 80 90 100
CDDGEILAVA DPKLGDIITE KLDIECVHND AVMELLRGVR SQLTELLSGL
110 120 130 140 150
DDNDLAPVSL ELSHILARYK LKITSDKVET MIILSISLLD DLDKELNTYT
160 170 180 190 200
TSVCELYGLH FPELANIVQD NILYAKVVKL MGNRINAATL DFSEILADEV
210 220 230 240 250
EAELKEASMV STRTEVSDLD LMHIQELCDQ VLSIAEDKTL LCDDLKNKMN
260 270 280 290 300
KIAPNLTALV GELVGARLIS HCGSLWNLSK LPWSTIQILG AEKTLYKALK
310 320 330 340 350
TKQATPKYGL IYHAPLVRQA APENKGKIAR SLAAKSALAI RCDAFGNGQD
360 370 380 390 400
NTMGVESRLK LEARLRNLEG GDLGACEEEE EVNDKDTKKE ADDEEEPKTE
410 420 430 440 450
ECSKKRKKEA ELETVEDPAK KSKQEGVTGL LLLMLLISLI YFFSVNQLLW
Length:450
Mass (Da):49,935
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i388773BE16346912
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB61074 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AED93654 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007271 Genomic DNA Translation: AAB61074.1 Sequence problems.
CP002688 Genomic DNA Translation: AED93654.1 Sequence problems.
CP002688 Genomic DNA Translation: ANM68536.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T01805

NCBI Reference Sequences

More...
RefSeqi
NP_001330282.1, NM_001343993.1
NP_198066.1, NM_122596.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G27140.2; AT5G27140.2; AT5G27140

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
832772

Gramene; a comparative resource for plants

More...
Gramenei
AT5G27140.2; AT5G27140.2; AT5G27140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G27140

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007271 Genomic DNA Translation: AAB61074.1 Sequence problems.
CP002688 Genomic DNA Translation: AED93654.1 Sequence problems.
CP002688 Genomic DNA Translation: ANM68536.1
PIRiT01805
RefSeqiNP_001330282.1, NM_001343993.1
NP_198066.1, NM_122596.1

3D structure databases

SMRiO04656
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi18046, 37 interactors
STRINGi3702.AT5G27140.1

Proteomic databases

PaxDbiO04656
PRIDEiO04656
ProteomicsDBi251070

Genome annotation databases

EnsemblPlantsiAT5G27140.2; AT5G27140.2; AT5G27140
GeneIDi832772
GrameneiAT5G27140.2; AT5G27140.2; AT5G27140
KEGGiath:AT5G27140

Organism-specific databases

AraportiAT5G27140

Phylogenomic databases

eggNOGiKOG2572, Eukaryota
HOGENOMiCLU_015495_5_2_1
InParanoidiO04656
OrthoDBi632707at2759
PhylomeDBiO04656

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O04656

Gene expression databases

ExpressionAtlasiO04656, baseline and differential
GenevisibleiO04656, AT

Family and domain databases

Gene3Di1.10.246.90, 1 hit
InterProiView protein in InterPro
IPR045056, Nop56/Nop58
IPR012974, NOP5_N
IPR042239, Nop_C
IPR002687, Nop_dom
IPR036070, Nop_dom_sf
IPR012976, NOSIC
PANTHERiPTHR10894, PTHR10894, 2 hits
PfamiView protein in Pfam
PF01798, Nop, 1 hit
PF08156, NOP5NT, 1 hit
SMARTiView protein in SMART
SM00931, NOSIC, 1 hit
SUPFAMiSSF89124, SSF89124, 1 hit
PROSITEiView protein in PROSITE
PS51358, NOP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOP5C_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O04656
Secondary accession number(s): F4K2U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 15, 2007
Last modified: February 23, 2022
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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