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Protein

Thylakoidal processing peptidase 1, chloroplastic

Gene

TPP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves the thylakoid-transfer domain from a chloroplast protein.1 Publication

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184By similarity1

GO - Molecular functioni

  • endopeptidase activity Source: TAIR
  • serine-type peptidase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.008

Names & Taxonomyi

Protein namesi
Recommended name:
Thylakoidal processing peptidase 1, chloroplastic (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I-1
Gene namesi
Name:TPP1
Ordered Locus Names:At2g30440
ORF Names:T6B20.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G30440
TAIRilocus:2064337 AT2G30440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 340Lumenal, thylakoidSequence analysisAdd BLAST165

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000310734? – 340Thylakoidal processing peptidase 1, chloroplastic
Transit peptidei1 – 52ChloroplastSequence analysisAdd BLAST52
Transit peptidei53 – ?ThylakoidSequence analysis

Proteomic databases

PaxDbiO04348
PRIDEiO04348

Expressioni

Gene expression databases

ExpressionAtlasiO04348 baseline and differential
GenevisibleiO04348 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G30440.1

Structurei

3D structure databases

ProteinModelPortaliO04348
SMRiO04348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 135Poly-Asp5

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0171 Eukaryota
COG0681 LUCA
HOGENOMiHOG000243179
InParanoidiO04348
KOiK03100
OMAiFLQTAKW
OrthoDBiEOG09360HO1
PhylomeDBiO04348

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR019533 Peptidase_S26
PfamiView protein in Pfam
PF10502 Peptidase_S26, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O04348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIRITFTYS THVARNLVGT RVGPGGYCFE SLVRPRFFSH KRDFDRSPRN
60 70 80 90 100
RPASMYGSIA RELIGEGSQS PLVMGLISIL KSTTGHESST MNVLGVSSFK
110 120 130 140 150
ASSIIPFLQG SKWIKNPPVI DDVDKGGTVC DDDDDKESRN GGSGWVNKLL
160 170 180 190 200
SVCSEDAKAA FTAVTVSILF RSALAEPKSI PSTSMYPTLD KGDRVMAEKV
210 220 230 240 250
SYFFRKPEVS DIVIFKAPPI LLEYPEYGYS SNDVFIKRIV ASEGDWVEVR
260 270 280 290 300
DGKLFVNDIV QEEDFVLEPM SYEMEPMFVP KGYVFVLGDN RNKSFDSHNW
310 320 330 340
GPLPIENIVG RSVFRYWPPS KVSDTIYHDQ AITRGPVAVS
Length:340
Mass (Da):37,853
Last modified:November 1, 1998 - v2
Checksum:iF6763EBFC1DAA2E1
GO

Sequence cautioni

The sequence AAB63091 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10477 mRNA Translation: CAA71502.1
U93215 Genomic DNA Translation: AAB63091.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08389.1
AY128354 mRNA Translation: AAM91557.1
BT020607 mRNA Translation: AAW80880.1
PIRiE84708
RefSeqiNP_180603.2, NM_128597.3
UniGeneiAt.10032

Genome annotation databases

EnsemblPlantsiAT2G30440.1; AT2G30440.1; AT2G30440
GeneIDi817595
GrameneiAT2G30440.1; AT2G30440.1; AT2G30440
KEGGiath:AT2G30440

Similar proteinsi

Entry informationi

Entry nameiTPP1_ARATH
AccessioniPrimary (citable) accession number: O04348
Secondary accession number(s): Q7DM64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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