UniProtKB - O04291 (ATB14_ARATH)
Protein
Homeobox-leucine zipper protein ATHB-14
Gene
ATHB-14
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Probable transcription factor involved in the determination of adaxial-abaxial polarity in ovule primordium. Specifies adaxial leaf fates.3 Publications
Activity regulationi
Inhibited by ZPR3.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 22 – 85 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 64 |
GO - Molecular functioni
- DNA binding Source: TAIR
- DNA-binding transcription factor activity Source: TAIR
- lipid binding Source: InterPro
GO - Biological processi
- adaxial/abaxial pattern specification Source: TAIR
- cell differentiation Source: UniProtKB-KW
- determination of bilateral symmetry Source: TAIR
- integument development Source: TAIR
- meristem initiation Source: TAIR
- polarity specification of adaxial/abaxial axis Source: TAIR
- primary shoot apical meristem specification Source: TAIR
Keywordsi
Molecular function | DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox-leucine zipper protein ATHB-14Alternative name(s): HD-ZIP protein ATHB-14 Homeodomain transcription factor ATHB-14 Protein PHABULOSA |
Gene namesi | Name:ATHB-14 Synonyms:PHB Ordered Locus Names:At2g34710 ORF Names:T29F13.8 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G34710 |
TAIRi | locus:2061544, AT2G34710 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: TAIR
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 202 | G → D in phb-3d, phb-4d and phb-5d; constitutively active. Transformation of abaxial leaf fates into adaxial leaf fates. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331660 | 1 – 852 | Homeobox-leucine zipper protein ATHB-14Add BLAST | 852 |
Proteomic databases
PaxDbi | O04291 |
PRIDEi | O04291 |
ProteomicsDBi | 246717 |
PTM databases
iPTMneti | O04291 |
Expressioni
Tissue specificityi
Expressed in the center of the meristem and on the adaxial side of the leaves.1 Publication
Developmental stagei
Expressed at the youngest stages of ovule development, predominantly to the adaxial side of the ovule primordium. Later, expression becomes restricted to a region in the distal chalaza. When the integuments initiate, expressed in the inner integument, with highest expression in the inner layer of the inner integument. Expressed in the vegetative shoot apical meristem (SAM) and initially throughout the presumptive cotyledons. At the globular stage, just before cotyledon outgrowth, expressed at high levels in cotyledon adaxial domains. Expression is lost from the SAM of torpedo stage embryos but is regained late in embryogenesis, extending to young primordia after germination, and becoming progressively restricted to the adaxial domain and the vasculature. Preferentially expressed in the adaxial domain of the developing leaf. Expressed throughout the plastochron 0 (P0) leaf primordium and expression increases in P1 to become preferentially localized to the adaxial leaf domain by the P2 stage (polar expression).2 Publications
Inductioni
Repressed by miR165 and miR166.3 Publications
Gene expression databases
ExpressionAtlasi | O04291, baseline and differential |
Genevisiblei | O04291, AT |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 3382, 5 interactors |
IntActi | O04291, 3 interactors |
STRINGi | 3702.AT2G34710.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 164 – 392 | STARTPROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 80 – 130 | ZIP domain1 PublicationAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 80 – 122 | Sequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 12 | Met-richPROSITE-ProRule annotationAdd BLAST | 12 | |
Compositional biasi | 149 – 162 | Gln-richPROSITE-ProRule annotationAdd BLAST | 14 |
Domaini
The ZIP domain (80-130) is necessary and sufficient for the interaction with ZPR3 (PubMed:18408069).1 Publication
Sequence similaritiesi
Keywords - Domaini
Coiled coil, HomeoboxPhylogenomic databases
eggNOGi | ENOG502QPKR, Eukaryota |
HOGENOMi | CLU_012517_0_0_1 |
InParanoidi | O04291 |
OMAi | QNPNPQH |
OrthoDBi | 146876at2759 |
PhylomeDBi | O04291 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR013978, MEKHLA IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF08670, MEKHLA, 1 hit PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00234, START, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit PS50848, START, 1 hit |
i Sequence
Sequence statusi: Complete.
O04291-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMMVHSMSRD MMNRESPDKG LDSGKYVRYT PEQVEALERV YTECPKPSSL
60 70 80 90 100
RRQQLIRECP ILSNIEPKQI KVWFQNRRCR EKQRKEAARL QTVNRKLNAM
110 120 130 140 150
NKLLMEENDR LQKQVSNLVY ENGHMKHQLH TASGTTTDNS CESVVVSGQQ
160 170 180 190 200
HQQQNPNPQH QQRDANNPAG LLSIAEEALA EFLSKATGTA VDWVQMIGMK
210 220 230 240 250
PGPDSIGIVA ISRNCSGIAA RACGLVSLEP MKVAEILKDR PSWLRDCRSV
260 270 280 290 300
DTLSVIPAGN GGTIELIYTQ MYAPTTLAAA RDFWTLRYST CLEDGSYVVC
310 320 330 340 350
ERSLTSATGG PTGPPSSNFV RAEMKPSGFL IRPCDGGGSI LHIVDHVDLD
360 370 380 390 400
AWSVPEVMRP LYESSKILAQ KMTVAALRHV RQIAQETSGE VQYGGGRQPA
410 420 430 440 450
VLRTFSQRLC RGFNDAVNGF VDDGWSPMGS DGAEDVTVMI NLSPGKFGGS
460 470 480 490 500
QYGNSFLPSF GSGVLCAKAS MLLQNVPPAV LVRFLREHRS EWADYGVDAY
510 520 530 540 550
AAASLRASPF AVPCARAGGF PSNQVILPLA QTVEHEESLE VVRLEGHAYS
560 570 580 590 600
PEDMGLARDM YLLQLCSGVD ENVVGGCAQL VFAPIDESFA DDAPLLPSGF
610 620 630 640 650
RIIPLEQKST PNGASANRTL DLASALEGST RQAGEADPNG CNFRSVLTIA
660 670 680 690 700
FQFTFDNHSR DSVASMARQY VRSIVGSIQR VALAIAPRPG SNISPISVPT
710 720 730 740 750
SPEALTLVRW ISRSYSLHTG ADLFGSDSQT SGDTLLHQLW NHSDAILCCS
760 770 780 790 800
LKTNASPVFT FANQTGLDML ETTLVALQDI MLDKTLDEPG RKALCSEFPK
810 820 830 840 850
IMQQGYAHLP AGVCASSMGR MVSYEQATVW KVLEDDESNH CLAFMFVNWS
FV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11122 Genomic DNA Translation: CAA72007.1 AJ441291 mRNA Translation: CAD29659.1 AC003096 Genomic DNA Translation: AAC16263.1 CP002685 Genomic DNA Translation: AEC09012.1 AY099791 mRNA Translation: AAM20642.1 BT000335 mRNA Translation: AAN15654.1 |
PIRi | T01364 |
RefSeqi | NP_181018.1, NM_129025.4 |
Genome annotation databases
EnsemblPlantsi | AT2G34710.1; AT2G34710.1; AT2G34710 |
GeneIDi | 818036 |
Gramenei | AT2G34710.1; AT2G34710.1; AT2G34710 |
KEGGi | ath:AT2G34710 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11122 Genomic DNA Translation: CAA72007.1 AJ441291 mRNA Translation: CAD29659.1 AC003096 Genomic DNA Translation: AAC16263.1 CP002685 Genomic DNA Translation: AEC09012.1 AY099791 mRNA Translation: AAM20642.1 BT000335 mRNA Translation: AAN15654.1 |
PIRi | T01364 |
RefSeqi | NP_181018.1, NM_129025.4 |
3D structure databases
SMRi | O04291 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 3382, 5 interactors |
IntActi | O04291, 3 interactors |
STRINGi | 3702.AT2G34710.1 |
PTM databases
iPTMneti | O04291 |
Proteomic databases
PaxDbi | O04291 |
PRIDEi | O04291 |
ProteomicsDBi | 246717 |
Genome annotation databases
EnsemblPlantsi | AT2G34710.1; AT2G34710.1; AT2G34710 |
GeneIDi | 818036 |
Gramenei | AT2G34710.1; AT2G34710.1; AT2G34710 |
KEGGi | ath:AT2G34710 |
Organism-specific databases
Araporti | AT2G34710 |
TAIRi | locus:2061544, AT2G34710 |
Phylogenomic databases
eggNOGi | ENOG502QPKR, Eukaryota |
HOGENOMi | CLU_012517_0_0_1 |
InParanoidi | O04291 |
OMAi | QNPNPQH |
OrthoDBi | 146876at2759 |
PhylomeDBi | O04291 |
Miscellaneous databases
PROi | PR:O04291 |
Gene expression databases
ExpressionAtlasi | O04291, baseline and differential |
Genevisiblei | O04291, AT |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR013978, MEKHLA IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF08670, MEKHLA, 1 hit PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00234, START, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit PS50848, START, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATB14_ARATH | |
Accessioni | O04291Primary (citable) accession number: O04291 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families