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Entry version 113 (02 Jun 2021)
Sequence version 1 (01 Jul 1997)
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Protein

Protein EARLY FLOWERING 4

Gene

ELF4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. Increases ELF3 nuclear distribution and localization in nuclear bodies. Required for responsiveness to continuous red, by regulating phytochrome B (phyB) signaling (including during seedling de-etiolation) and gene expression. Mediates both entrainment to an environmental cycle and circadian rhythm sustainability under constant conditions. Controls flowering time. Necessary for light-induced expression of both CCA1 and LHY.

9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms, Flowering, Phytochrome signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein EARLY FLOWERING 4
Alternative name(s):
Protein ARRHYTHMIC 44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELF4
Synonyms:ARR08, ARR16, ARR19, ARR44, ARR80
Ordered Locus Names:At2g40080
ORF Names:T28M21.24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G40080

The Arabidopsis Information Resource

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TAIRi
locus:2061226, AT2G40080

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impaired in their ability to sense day length leading to early flowering in non-inductive photoperiods (probably through the misexpression of CO), and elongated hypocotyls and petioles in short days (SD). Attenuated light-regulated expression of CCA1 and LHY, central oscillator components. Transient output rhythms with highly variable period lengths before becoming arrhythmic. Reduced responsiveness to continuous red, but not continuous far-red light, suggesting a role in phyB signaling but not phyA signaling.8 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15E → K in elf4-201; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1
Mutagenesisi18E → K in elf4-202; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1
Mutagenesisi23P → L in elf4-208; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1
Mutagenesisi31R → Q in elf4-210; reduced homodimer stability associated with an impaired circadian gene regulation. 1 Publication1
Mutagenesisi31R → W in elf4-203; reduced homodimer stability associated with a strongly impaired circadian rhythm (short-period phenotype). 1 Publication1
Mutagenesisi34R → K in elf4-204; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1
Mutagenesisi44R → K in elf4-205; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1
Mutagenesisi45S → L in elf4-211; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1
Mutagenesisi59A → V in elf4-212; reduced homodimer stability associated with a strongly impaired circadian rhythm (short-period phenotype). 1 Publication1
Mutagenesisi74G → R in elf4-213; reduced homodimer stability associated with a slightly impaired circadian gene regulation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004085021 – 111Protein EARLY FLOWERING 4Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O04211

PRoteomics IDEntifications database

More...
PRIDEi
O04211

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
221942

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O04211

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
O04211

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Follows a light-dependent circadian-regulated expression with a peak in the evening, about 12 hours after dawn. Induced in seedlings and roots by continuous far-red light (FRc) via the phyA signaling pathway and by continuous red light (Rc) via the phyB signaling pathway. This light-mediated induction is repressed by ELF3, CCA1 and LHY.6 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O04211, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O04211, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ELF3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
3934, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1291, Evening Complex

Protein interaction database and analysis system

More...
IntActi
O04211, 9 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G40080.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O04211

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni90 – 111DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EARLY FLOWERING 4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S43Z, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_119738_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O04211

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTDFTNM

Database of Orthologous Groups

More...
OrthoDBi
1527684at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O04211

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040462, EARLY_FLOWERING_4
IPR009741, EARLY_FLOWERING_4_dom

The PANTHER Classification System

More...
PANTHERi
PTHR33469, PTHR33469, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07011, Elf4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O04211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRNGETKRR RNVAEEAEQG EDPAMWENLD RNFRQVQSVL DRNRSLIQQV
60 70 80 90 100
NDNHQSRMAD NMSKNVALIQ ELNGNISKVV NMYSDLNTSF SSGFHGGKNG
110
HDGGGAAGTR A
Length:111
Mass (Da):12,376
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79CBE01F1D410891
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF002109 Genomic DNA Translation: AAB95293.1
CP002685 Genomic DNA Translation: AEC09773.1
AY035183 mRNA Translation: AAK59687.1
AY062963 mRNA Translation: AAL33809.1
AY088748 mRNA Translation: AAM67064.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A84825

NCBI Reference Sequences

More...
RefSeqi
NP_565922.1, NM_129566.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G40080.1; AT2G40080.1; AT2G40080

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
818596

Gramene; a comparative resource for plants

More...
Gramenei
AT2G40080.1; AT2G40080.1; AT2G40080

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G40080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002109 Genomic DNA Translation: AAB95293.1
CP002685 Genomic DNA Translation: AEC09773.1
AY035183 mRNA Translation: AAK59687.1
AY062963 mRNA Translation: AAL33809.1
AY088748 mRNA Translation: AAM67064.1
PIRiA84825
RefSeqiNP_565922.1, NM_129566.2

3D structure databases

SMRiO04211
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi3934, 19 interactors
ComplexPortaliCPX-1291, Evening Complex
IntActiO04211, 9 interactors
STRINGi3702.AT2G40080.1

PTM databases

iPTMnetiO04211
MetOSiteiO04211

Proteomic databases

PaxDbiO04211
PRIDEiO04211
ProteomicsDBi221942

Genome annotation databases

EnsemblPlantsiAT2G40080.1; AT2G40080.1; AT2G40080
GeneIDi818596
GrameneiAT2G40080.1; AT2G40080.1; AT2G40080
KEGGiath:AT2G40080

Organism-specific databases

AraportiAT2G40080
TAIRilocus:2061226, AT2G40080

Phylogenomic databases

eggNOGiENOG502S43Z, Eukaryota
HOGENOMiCLU_119738_2_1_1
InParanoidiO04211
OMAiNTDFTNM
OrthoDBi1527684at2759
PhylomeDBiO04211

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O04211

Gene expression databases

ExpressionAtlasiO04211, baseline and differential
GenevisibleiO04211, AT

Family and domain databases

InterProiView protein in InterPro
IPR040462, EARLY_FLOWERING_4
IPR009741, EARLY_FLOWERING_4_dom
PANTHERiPTHR33469, PTHR33469, 1 hit
PfamiView protein in Pfam
PF07011, Elf4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELF4_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O04211
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 1, 1997
Last modified: June 2, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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