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Entry version 151 (16 Oct 2019)
Sequence version 1 (01 Jul 1997)
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Protein

Coronatine-insensitive protein 1

Gene

COI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity. Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. Involved in the regulation of plant gene expression during plant-pathogen interactions with Pseudomonas syringae and Alternaria brassicicola.9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei85JasmonateCombined sources1 Publication1
Binding sitei348JasmonateCombined sources1 Publication1
Binding sitei386JasmonateCombined sources1 Publication1
Binding sitei409JasmonateCombined sources1 Publication1
Binding sitei496JasmonateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processJasmonic acid signaling pathway, Plant defense, Ubl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coronatine-insensitive protein 1
Alternative name(s):
COI-1
F-box/LRR-repeat protein 2
Short name:
AtCOI1
Short name:
AtFBL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COI1
Synonyms:FBL2
Ordered Locus Names:At2g39940
ORF Names:T28M21.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT2G39940

The Arabidopsis Information Resource

More...
TAIRi
locus:2061136 AT2G39940

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants coi1-1 to coi1-14 are male sterile, insensitive to MeJA and coronatine, and exhibit enhanced resistance to Pseudomonas syringae atropurpurea (coronatine producing strain). Mutant coi1-16 has reduced sensitivity to jasmonate, but is male fertile when grown below 22 degrees Celsius and male sterile otherwise.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11L → A: No effects on interactions. 1 Publication1
Mutagenesisi22E → A: Abrogates SFC(COI1) complexes formation, loss of response to jasmonate. 1 Publication1
Mutagenesisi44W → A: Abrogates SFC(COI1) complexes formation and of interactions with RBCS-1B and RPD3B, loss of response to jasmonate. 1 Publication1
Mutagenesisi85R → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi88M → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi89F → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi121R → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi245L → F in coi1-16; abrogates interactions with RBCS-1B and RPD3B (coi1-16). 2 Publications1
Mutagenesisi301L → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi302Y → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi326R → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi348R → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi351R → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi386Y → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi409R → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi444Y → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi469L → A: Loss of interaction with TIFY10A. 1 Publication1
Mutagenesisi496R → A: Loss of interaction with TIFY10A. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199601 – 592Coronatine-insensitive protein 1Add BLAST592

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O04197

PRoteomics IDEntifications database

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PRIDEi
O04197

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O04197 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O04197 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of SCF(COI1) E3 ubiquitin ligase complexes at least composed of ASK1 or ASK2, CUL1, RBX1A or RBX1B and COI1.

Interacts with ASK1 and ASK2, but separately, Binds also to ASK11 and ASK12.

Interacts with RBCS-1B and HDA6. SCF complexes interact with the COP9 signalosome (CSN).

Interacts with TIFY10A.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
3919, 21 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1339 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1429 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1430 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1431 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1432 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1433 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1434 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1435 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1436 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1437 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1438 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1439 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1440 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1441 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1442 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1443 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1444 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1445 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1446 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1447 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1448 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1449 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1A
CPX-1450 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1B
CPX-1451 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK3
CPX-1452 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1453 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK5
CPX-1454 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK6
CPX-1455 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK7
CPX-1456 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK8
CPX-1457 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK9
CPX-1458 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK10
CPX-1459 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK11
CPX-1460 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK12
CPX-1461 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK13
CPX-1462 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK14
CPX-1463 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK15
CPX-1464 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK16
CPX-1465 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17
CPX-1466 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK18
CPX-1467 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK19
CPX-1468 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK20
CPX-1469 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK21
CPX-1471 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
CPX-1472 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
CPX-1473 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
CPX-1474 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1475 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5
CPX-1476 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6
CPX-1477 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7
CPX-1478 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8
CPX-1479 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9
CPX-1480 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10
CPX-1481 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11
CPX-1482 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12
CPX-1483 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13
CPX-1484 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14
CPX-1485 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15
CPX-1486 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16
CPX-1487 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17
CPX-1488 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18
CPX-1489 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19
CPX-1490 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20
CPX-1491 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21
CPX-1492 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1A
CPX-1493 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1B
CPX-1494 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK3
CPX-1495 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4
CPX-1496 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK5
CPX-1497 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK6
CPX-1498 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK7
CPX-1499 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK8
CPX-1502 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK9
CPX-1503 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK10
CPX-1504 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK11
CPX-1505 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK12
CPX-1506 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK13
CPX-1507 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK14
CPX-1508 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK15
CPX-1509 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK16
CPX-1510 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK17
CPX-1511 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK18
CPX-1512 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK19
CPX-1513 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK20
CPX-1514 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK21

Database of interacting proteins

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DIPi
DIP-31324N

Protein interaction database and analysis system

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IntActi
O04197, 14 interactors

STRING: functional protein association networks

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STRINGi
3702.AT2G39940.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1592
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O04197

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O04197

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 57F-boxAdd BLAST42
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 82LRR 1Add BLAST25
Repeati83 – 102LRR 2Add BLAST20
Repeati103 – 120LRR 3Add BLAST18
Repeati121 – 154LRR 4Add BLAST34
Repeati155 – 182LRR 5Add BLAST28
Repeati183 – 210LRR 6Add BLAST28
Repeati211 – 236LRR 7Add BLAST26
Repeati237 – 264LRR 8Add BLAST28
Repeati265 – 283LRR 8Add BLAST19
Repeati284 – 308LRR 10Add BLAST25
Repeati309 – 332LRR 11Add BLAST24
Repeati333 – 368LRR 12Add BLAST36
Repeati369 – 393LRR 13Add BLAST25
Repeati394 – 426LRR 14Add BLAST33
Repeati427 – 456LRR 15Add BLAST30
Repeati457 – 478LRR 16Add BLAST22
Repeati479 – 500LRR 17Add BLAST22
Repeati501 – 524LRR 18Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi102 – 517Leu-richAdd BLAST416

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The F-box domain is essential for the formation of SFC(COI1) complexes.1 Publication
The Leu-rich domain is involved in the interactions with RBCS-1B and RPD3B.1 Publication

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1947 Eukaryota
ENOG410XQ54 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000238474

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O04197

KEGG Orthology (KO)

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KOi
K13463

Identification of Orthologs from Complete Genome Data

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OMAi
RVPEVNQ

Database of Orthologous Groups

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OrthoDBi
444688at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O04197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041567 COI1_F-box
IPR032675 LRR_dom_sf
IPR041101 Transp_inhibit

Pfam protein domain database

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Pfami
View protein in Pfam
PF18511 F-box_5, 1 hit
PF18791 Transp_inhibit, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O04197-1 [UniParc]FASTAAdd to basket
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        10         20         30         40         50
MEDPDIKRCK LSCVATVDDV IEQVMTYITD PKDRDSASLV CRRWFKIDSE
60 70 80 90 100
TREHVTMALC YTATPDRLSR RFPNLRSLKL KGKPRAAMFN LIPENWGGYV
110 120 130 140 150
TPWVTEISNN LRQLKSVHFR RMIVSDLDLD RLAKARADDL ETLKLDKCSG
160 170 180 190 200
FTTDGLLSIV THCRKIKTLL MEESSFSEKD GKWLHELAQH NTSLEVLNFY
210 220 230 240 250
MTEFAKISPK DLETIARNCR SLVSVKVGDF EILELVGFFK AAANLEEFCG
260 270 280 290 300
GSLNEDIGMP EKYMNLVFPR KLCRLGLSYM GPNEMPILFP FAAQIRKLDL
310 320 330 340 350
LYALLETEDH CTLIQKCPNL EVLETRNVIG DRGLEVLAQY CKQLKRLRIE
360 370 380 390 400
RGADEQGMED EEGLVSQRGL IALAQGCQEL EYMAVYVSDI TNESLESIGT
410 420 430 440 450
YLKNLCDFRL VLLDREERIT DLPLDNGVRS LLIGCKKLRR FAFYLRQGGL
460 470 480 490 500
TDLGLSYIGQ YSPNVRWMLL GYVGESDEGL MEFSRGCPNL QKLEMRGCCF
510 520 530 540 550
SERAIAAAVT KLPSLRYLWV QGYRASMTGQ DLMQMARPYW NIELIPSRRV
560 570 580 590
PEVNQQGEIR EMEHPAHILA YYSLAGQRTD CPTTVRVLKE PI
Length:592
Mass (Da):67,665
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DDCF04990144C06
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF036340 mRNA Translation: AAC17498.1
EF470606 Genomic DNA Translation: ABR45936.1
EF470607 Genomic DNA Translation: ABR45937.1
EF470608 Genomic DNA Translation: ABR45938.1
EF470609 Genomic DNA Translation: ABR45939.1
EF470610 Genomic DNA Translation: ABR45940.1
EF470611 Genomic DNA Translation: ABR45941.1
EF470612 Genomic DNA Translation: ABR45942.1
EF470613 Genomic DNA Translation: ABR45943.1
EF470614 Genomic DNA Translation: ABR45944.1
EF470615 Genomic DNA Translation: ABR45945.1
EF470616 Genomic DNA Translation: ABR45946.1
EF470617 Genomic DNA Translation: ABR45947.1
EF470619 Genomic DNA Translation: ABR45949.1
EF470620 Genomic DNA Translation: ABR45950.1
EF470621 Genomic DNA Translation: ABR45951.1
EF470622 Genomic DNA Translation: ABR45952.1
EF470623 Genomic DNA Translation: ABR45953.1
EF470624 Genomic DNA Translation: ABR45954.1
AF002109 Genomic DNA Translation: AAB95279.1
CP002685 Genomic DNA Translation: AEC09753.1
AY045625 mRNA Translation: AAK73983.1
AY133556 mRNA Translation: AAM91386.1

Protein sequence database of the Protein Information Resource

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PIRi
T52139

NCBI Reference Sequences

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RefSeqi
NP_565919.1, NM_129552.4

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT2G39940.1; AT2G39940.1; AT2G39940

Database of genes from NCBI RefSeq genomes

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GeneIDi
818581

Gramene; a comparative resource for plants

More...
Gramenei
AT2G39940.1; AT2G39940.1; AT2G39940

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G39940

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036340 mRNA Translation: AAC17498.1
EF470606 Genomic DNA Translation: ABR45936.1
EF470607 Genomic DNA Translation: ABR45937.1
EF470608 Genomic DNA Translation: ABR45938.1
EF470609 Genomic DNA Translation: ABR45939.1
EF470610 Genomic DNA Translation: ABR45940.1
EF470611 Genomic DNA Translation: ABR45941.1
EF470612 Genomic DNA Translation: ABR45942.1
EF470613 Genomic DNA Translation: ABR45943.1
EF470614 Genomic DNA Translation: ABR45944.1
EF470615 Genomic DNA Translation: ABR45945.1
EF470616 Genomic DNA Translation: ABR45946.1
EF470617 Genomic DNA Translation: ABR45947.1
EF470619 Genomic DNA Translation: ABR45949.1
EF470620 Genomic DNA Translation: ABR45950.1
EF470621 Genomic DNA Translation: ABR45951.1
EF470622 Genomic DNA Translation: ABR45952.1
EF470623 Genomic DNA Translation: ABR45953.1
EF470624 Genomic DNA Translation: ABR45954.1
AF002109 Genomic DNA Translation: AAB95279.1
CP002685 Genomic DNA Translation: AEC09753.1
AY045625 mRNA Translation: AAK73983.1
AY133556 mRNA Translation: AAM91386.1
PIRiT52139
RefSeqiNP_565919.1, NM_129552.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OGKX-ray2.80B/D/F/H/J/L/N/P1-592[»]
3OGLX-ray3.18B/D/F/H/J/L/N/P1-592[»]
3OGMX-ray3.34B/D/F/H/J/L/N/P1-592[»]
SMRiO04197
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi3919, 21 interactors
ComplexPortaliCPX-1339 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1A
CPX-1429 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-SKP1B
CPX-1430 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK3
CPX-1431 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK4
CPX-1432 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK5
CPX-1433 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK6
CPX-1434 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK7
CPX-1435 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK8
CPX-1436 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK9
CPX-1437 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK10
CPX-1438 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK11
CPX-1439 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK12
CPX-1440 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK13
CPX-1441 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK14
CPX-1442 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK15
CPX-1443 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK16
CPX-1444 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK17
CPX-1445 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK18
CPX-1446 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK19
CPX-1447 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK20
CPX-1448 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1A-ASK21
CPX-1449 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1A
CPX-1450 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-SKP1B
CPX-1451 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK3
CPX-1452 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK4
CPX-1453 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK5
CPX-1454 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK6
CPX-1455 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK7
CPX-1456 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK8
CPX-1457 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK9
CPX-1458 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK10
CPX-1459 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK11
CPX-1460 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK12
CPX-1461 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK13
CPX-1462 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK14
CPX-1463 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK15
CPX-1464 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK16
CPX-1465 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK17
CPX-1466 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK18
CPX-1467 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK19
CPX-1468 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK20
CPX-1469 SCF(COI1) ubiquitin ligase complex, variant CUL1-RBX1B-ASK21
CPX-1471 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
CPX-1472 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
CPX-1473 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
CPX-1474 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
CPX-1475 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5
CPX-1476 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK6
CPX-1477 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK7
CPX-1478 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK8
CPX-1479 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK9
CPX-1480 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK10
CPX-1481 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK11
CPX-1482 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK12
CPX-1483 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK13
CPX-1484 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK14
CPX-1485 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK15
CPX-1486 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK16
CPX-1487 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK17
CPX-1488 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK18
CPX-1489 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK19
CPX-1490 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK20
CPX-1491 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK21
CPX-1492 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1A
CPX-1493 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-SKP1B
CPX-1494 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK3
CPX-1495 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK4
CPX-1496 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK5
CPX-1497 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK6
CPX-1498 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK7
CPX-1499 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK8
CPX-1502 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK9
CPX-1503 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK10
CPX-1504 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK11
CPX-1505 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK12
CPX-1506 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK13
CPX-1507 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK14
CPX-1508 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK15
CPX-1509 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK16
CPX-1510 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK17
CPX-1511 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK18
CPX-1512 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK19
CPX-1513 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK20
CPX-1514 SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1B-ASK21
DIPiDIP-31324N
IntActiO04197, 14 interactors
STRINGi3702.AT2G39940.1

Proteomic databases

PaxDbiO04197
PRIDEiO04197

Genome annotation databases

EnsemblPlantsiAT2G39940.1; AT2G39940.1; AT2G39940
GeneIDi818581
GrameneiAT2G39940.1; AT2G39940.1; AT2G39940
KEGGiath:AT2G39940

Organism-specific databases

AraportiAT2G39940
TAIRilocus:2061136 AT2G39940

Phylogenomic databases

eggNOGiKOG1947 Eukaryota
ENOG410XQ54 LUCA
HOGENOMiHOG000238474
InParanoidiO04197
KOiK13463
OMAiRVPEVNQ
OrthoDBi444688at2759
PhylomeDBiO04197

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

EvolutionaryTraceiO04197

Protein Ontology

More...
PROi
PR:O04197

Gene expression databases

ExpressionAtlasiO04197 baseline and differential
GenevisibleiO04197 AT

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR041567 COI1_F-box
IPR032675 LRR_dom_sf
IPR041101 Transp_inhibit
PfamiView protein in Pfam
PF18511 F-box_5, 1 hit
PF18791 Transp_inhibit, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOI1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O04197
Secondary accession number(s): B2BD84
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 1, 1997
Last modified: October 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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