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Protein

Protein-arginine deiminase type-3

Gene

PADI3

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.By similarity

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.By similarity

Cofactori

Temperature dependencei

Optimum temperature is 37 degrees Celsius.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15By similarity)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene namesi
Name:PADI3
Synonyms:PAD, PAD3, PDI3
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200321 – 664Protein-arginine deiminase type-3Add BLAST664

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiO02849

Expressioni

Tissue specificityi

Found in wool follicles, keratinizing epithelia of the ruminal mucosa, empryonic hoof and tongue filiform papillae.

Structurei

3D structure databases

ProteinModelPortaliO02849
SMRiO02849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

HOVERGENiHBG053016
KOiK01481

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

O02849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQRIVRVS LEHPTSAVCV AGVETLVDVY GSVPEGTEMF EVYGTPGVDV
60 70 80 90 100
YICPSVERDR ERAVARRWHF DMGSQIVVVM NSPSNVNDTV TFKFPTIPAE
110 120 130 140 150
TPRPLAYAVL YLTCVDITLD CDLNCEGRQD RDFVDKLQWV WGPSGHGAVL
160 170 180 190 200
LVNCDRDSMS SNDQEHCDHH VRCLQDLEDM SVMILRTQGP DALFDDHKLV
210 220 230 240 250
LHTSRADAER ARVFHACGPE DSCEAYRHVL GQNKVSYEVP RFHGEEERFF
260 270 280 290 300
VEGLSFPDAG FSGLVTFHVT LLDDSNEDFS ESPIFTDTVV FRVAPWIMTP
310 320 330 340 350
STQPPLEVYV CRVRNNTCFV DAVAELARRA GCKLTVCPQA ENRNDRWIQD
360 370 380 390 400
EMELGYIQAP HKTFPVVFDS PRNGELQNFP YKRILGPDFG YATREPRDNS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILF GGNLPGSRGR RVTQVVRDFL
460 470 480 490 500
HAQKVQPPVE LFVDWLAVGH VDECLSFVPA TDGKGFRMPL ASPSACFKLF
510 520 530 540 550
QEKQKWGHGG ALLFQGVIGN QQVNTVSISQ VLSNGSLIGY NKFVQSCIDW
560 570 580 590 600
NREVLKRELG LAERDIVDIP QLFKMERRKA VAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPVINGR CCLEEKVRSL LEPLGLRCTF IDDFTPYHML HGEVHCGTNV
660
RRQPFSFKWW CMEP
Length:664
Mass (Da):74,747
Last modified:July 1, 1997 - v1
Checksum:i8FB88CE04AD0E5C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85264 mRNA Translation: AAB53205.1
RefSeqiNP_001009791.1, NM_001009791.1
UniGeneiOar.880

Genome annotation databases

GeneIDi443369
KEGGioas:443369

Similar proteinsi

Entry informationi

Entry nameiPADI3_SHEEP
AccessioniPrimary (citable) accession number: O02849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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