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Protein

Alpha-1A adrenergic receptor

Gene

ADRA1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:ADRA1A
Synonyms:ADRA1C
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularBy similarityAdd BLAST25
Transmembranei26 – 51Helical; Name=1By similarityAdd BLAST26
Topological domaini52 – 63CytoplasmicBy similarityAdd BLAST12
Transmembranei64 – 89Helical; Name=2By similarityAdd BLAST26
Topological domaini90 – 99ExtracellularBy similarity10
Transmembranei100 – 122Helical; Name=3By similarityAdd BLAST23
Topological domaini123 – 143CytoplasmicBy similarityAdd BLAST21
Transmembranei144 – 168Helical; Name=4By similarityAdd BLAST25
Topological domaini169 – 181ExtracellularBy similarityAdd BLAST13
Transmembranei182 – 205Helical; Name=5By similarityAdd BLAST24
Topological domaini206 – 272CytoplasmicBy similarityAdd BLAST67
Transmembranei273 – 297Helical; Name=6By similarityAdd BLAST25
Topological domaini298 – 304ExtracellularBy similarity7
Transmembranei305 – 329Helical; Name=7By similarityAdd BLAST25
Topological domaini330 – 466CytoplasmicBy similarityAdd BLAST137

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3637

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690651 – 466Alpha-1A adrenergic receptorAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi345S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Expressioni

Tissue specificityi

Abundant in liver, vas deferens, brain, and aorta, but not in heart.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018013

Chemistry databases

BindingDBiO02824

Structurei

3D structure databases

ProteinModelPortaliO02824
SMRiO02824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi334 – 349Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiO02824
KOiK04135

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001004 ADRA1A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00557 ADRENRGCA1AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O02824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFLSGNASD SSNCTHPPAP VNISKAILLG VILGGLILFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIISLCVI SIDRYIGVSY PLRYPTIVTQ RRGLRALLCV
160 170 180 190 200
WAFSLVISVG PLFGWRQPAP DDETICQINE EPGYVLFSAL GSFYVPLTII
210 220 230 240 250
LAMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN APAGGSGVAS
260 270 280 290 300
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
310 320 330 340 350
FKPPETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LKIQCLRRKQ
360 370 380 390 400
SSKHALGYTL HAPSQALEGQ HKDMVRIPVG SGETFYKISK TDGVCEWKFF
410 420 430 440 450
SSMPRGSARI TVPKDQSACT TARVRSKSFL QVCCCVGPST PNPGENHQVP
460
TIKIHTISLS ENGEEV
Length:466
Mass (Da):51,365
Last modified:July 1, 1997 - v1
Checksum:i9446D356B50FCDE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81982 mRNA Translation: AAB61334.1
RefSeqiNP_001075849.1, NM_001082380.1
UniGeneiOcu.2154

Genome annotation databases

GeneIDi100009237
KEGGiocu:100009237

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81982 mRNA Translation: AAB61334.1
RefSeqiNP_001075849.1, NM_001082380.1
UniGeneiOcu.2154

3D structure databases

ProteinModelPortaliO02824
SMRiO02824
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018013

Chemistry databases

BindingDBiO02824
ChEMBLiCHEMBL3637

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009237
KEGGiocu:100009237

Organism-specific databases

CTDi148

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiO02824
KOiK04135

Miscellaneous databases

PROiPR:O02824

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001004 ADRA1A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00557 ADRENRGCA1AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA1A_RABIT
AccessioniPrimary (citable) accession number: O02824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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