Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 119 (05 Jun 2019)
Sequence version 2 (17 Feb 2016)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Phosphatidylinositol 4-kinase alpha

Gene

PI4KA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Triton X-100, insensitive to inhibition by adenosine and inhibited by wortmannin. The PI4K complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis (By similarity). Interaction with TMEM150A regulates PtdIns4P synthesis (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase alpha (EC:2.7.1.67By similarity)
Short name:
PI4-kinase alpha
Short name:
PI4K-alpha
Short name:
PtdIns-4-kinase alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PI4KA
Synonyms:PIK4CA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3185

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002260471 – 2102Phosphatidylinositol 4-kinase alphaAdd BLAST2102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei257PhosphoserineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei260PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei429PhosphoserineBy similarity1
Modified residuei1154PhosphotyrosineBy similarity1
Modified residuei1436PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O02811

PRoteomics IDEntifications database

More...
PRIDEi
O02811

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000013971 Expressed in 9 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B).

Interacts with TMEM150A; regulating recruitment to the plasma membrane.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000018572

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O02811

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1530 – 1718PIK helicalPROSITE-ProRule annotationAdd BLAST189
Domaini1846 – 2079PI3K/PI4KPROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0902 Eukaryota
COG5032 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O02811

KEGG Orthology (KO)

More...
KOi
K00888

Database of Orthologous Groups

More...
OrthoDBi
1147978at2759

TreeFam database of animal gene trees

More...
TreeFami
TF102041

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O02811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAARGGG GGGGGGSFGS GAGGGASRGF YFNTVLSLAR SLAVQRPASL
60 70 80 90 100
EKVQKLLCMC PVDFHGIFQL DERRRDAVIA LGIFLIESDL QHKDSVVPYL
110 120 130 140 150
LRLLKGLPKV YWVEESTARK GRGTLPVAES FSFCLVTLLS DVAYRDPSLR
160 170 180 190 200
GEILEALLQV LHVLLGMCQA LEIQEKEYLC KHAVPCLLGI VRAFGRHSSS
210 220 230 240 250
EDSILSRLFP RAPAHSPRVP EELEGVRRRS FNDFRSILPS SLLTVCQEGS
260 270 280 290 300
LKRKASSASS VAQVSPERGA PPPSPPGGSA FHCLEASYSP NGSTSESDYY
310 320 330 340 350
FSAVSSSFSV SPLFNGVTYK EFSIPLEMLR ELLNLVKKIV EEPVLKSLDA
360 370 380 390 400
VVTGVIEASP SADLCYGAFS DPLYVAVLRM LRDTLYYMRD LPTSFVKEVH
410 420 430 440 450
DFVLEQFNSS QGELQKILHD ADRAHSELSP LKLRCQASAA CVDLMVWAVK
460 470 480 490 500
DEQGAENLCV KLSEKLQSKT SSKVIIAHLP LLICCLQGLG RLCERFPVVV
510 520 530 540 550
HSVTPSLRDF LVVPSPVLVK LYKCHSQYHT VAGNDIKISV TNEHAESTLN
560 570 580 590 600
VASGKKSQPS MYEQLRDIAI DNVCRCLKAG LTVDPVIVEA FLASLSNRLY
610 620 630 640 650
ISQESDKDAH LIPDHTIRAL GHIAVALRDT PKVMEPILQI LQQKFCQPPS
660 670 680 690 700
PLDVLIIDQL GCLVITGNQY IYQEVWNLFQ QISVKASSVV YSATKDYKDH
710 720 730 740 750
GYRHCSLAVI NALANIAANI QDEHLVDELL MNLLELFVQL GLEGKRASER
760 770 780 790 800
ASEKGPALKA SSSAGNLGVL IPVIAVLTRR LPPIKEPKPR LQKLFRDFWL
810 820 830 840 850
YSVLMGFAVE GSGLWPEEWY EGVCEIATKS PLLTFPSKEP LRSVLQYNSA
860 870 880 890 900
MKNDTVTPAE LSELRSTIVN LLDPAPEVSA LIGKLDFAMS TYLLSVYRLE
910 920 930 940 950
YMRVLRSSDP ARFQVMFCYF EDKAIQKDKS GMMQCVIAVA DKVFDAFLNM
960 970 980 990 1000
MAEKAKTKEN EEELERHAQF LLVSFNHVHK RIRRVADKYL SGLVDKFPHL
1010 1020 1030 1040 1050
LWSGTVLKTM LDILQTLSLS LSADIHKDQP YYDIPDVPYR ITVPDTYEAR
1060 1070 1080 1090 1100
ESIVKDFAAR CGMILQEAMK WAPTVTKSHL QEYLSKHQNW VSGLSQHTGL
1110 1120 1130 1140 1150
AMATESVLHY AGYNKQSTSL GATQLTERPA CVKKDYSNFM ASLNLRNRYA
1160 1170 1180 1190 1200
GEVYGMIRFS DATGHTSDLN KMMVQELKAA LGAGDAQQYT QAMFKLTAML
1210 1220 1230 1240 1250
ISSRDCDPQL LHHLCWGPLQ MFNEHGMETA LACWEWLLAG KNGVEVPFMR
1260 1270 1280 1290 1300
EMAGAWQMTV EQKFGLFSAE MKEADPLAAS EASQPKPCAP EVTPHYIWID
1310 1320 1330 1340 1350
FLVQRFEIAK YCSSDQVEIF CSLLQRSLSL SIGGTAGSMN RHVAAIGPRF
1360 1370 1380 1390 1400
KLLTLGLSLL HADVLPNATI RNVLREKIYS TAFDYFSCPP RFPTQGEKRL
1410 1420 1430 1440 1450
REDISVMIKF WTAMFSDKKY LTASQLVPPD NQDTRSNLDI AVGSRQQATQ
1460 1470 1480 1490 1500
GWINTYPLSS GMSTISKKSG MSKKTNRGSQ LHKYYMKRRT LLLSLLATEI
1510 1520 1530 1540 1550
ERLITWYNPL SAPELELDQA GESSVANWRS KYISLSEKQW KDNVNLAWSI
1560 1570 1580 1590 1600
SPHLAVQLPA RFKNTEAIGN EVTRLVRLDP GAVSDVPEAI KFLVTWHTID
1610 1620 1630 1640 1650
ADAPELSHVL CWAPADPPTG LSYFSSMYPP HPLTAQYGVK VLRSFPPDAI
1660 1670 1680 1690 1700
LFYIPQIVQA LRYDKMGYVR EYILWAASQS QLLAHQFIWN MKTNIYVDEE
1710 1720 1730 1740 1750
GHQKDPDIGD LLEQLVEEIT GSLSGPAKDF YQREFDFFNK ITNVSAIIKP
1760 1770 1780 1790 1800
YPKGDERKKA CLSALSEVKV QPGCYLPSNP EAIVLDIDYK SGTPMQSAAK
1810 1820 1830 1840 1850
APYLAKFKVK RCGVSELEKE GLRCRSDPEE EGSMQEADGQ KISWQAAIFK
1860 1870 1880 1890 1900
VGDDCRQDML ALQIIDLFKN IFQLVGLDLF VFPYRVVATA PGCGVIECIP
1910 1920 1930 1940 1950
DCTSRDQLGR QTDFGMYDYF TRQYGDESTL AFQQARYNFI RSMAAYSLLL
1960 1970 1980 1990 2000
FLLQIKDRHN GNIMLDKKGH LIHIDFGFMF ESSPGGNLGW EPDIKLTDEM
2010 2020 2030 2040 2050
VMIMGGKMEA TPFKWFMEMC VRGYLAVRPY MDAVVSLVTL MLDTGLPCFR
2060 2070 2080 2090 2100
GQTIKLLKHR FSPNMTEREA ANFILKVIQN CFLSNRSRTY DMIQYYQNDI

PY
Length:2,102
Mass (Da):235,149
Last modified:February 17, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9A5F0E9B7FD2F2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49 – 50SL → CV in AAC48730 (PubMed:9218477).Curated2
Sequence conflicti131F → L in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti204I → L in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti308F → L in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti366Y → H in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti478 – 479HL → QV in AAC48730 (PubMed:9218477).Curated2
Sequence conflicti583V → E in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti785K → E in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti917F → L in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti967 – 968HA → T in AAC48730 (PubMed:9218477).Curated2
Sequence conflicti1111A → S in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti1151G → A in AAC48730 (PubMed:9218477).Curated1
Sequence conflicti1628Y → S in AAC48730 (PubMed:9218477).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U88532 mRNA Translation: AAC48730.1
DAAA02045733 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_777002.1, NM_174577.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
282309

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:282309

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88532 mRNA Translation: AAC48730.1
DAAA02045733 Genomic DNA No translation available.
RefSeqiNP_777002.1, NM_174577.2

3D structure databases

SMRiO02811
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018572

Chemistry databases

ChEMBLiCHEMBL3185

Proteomic databases

PaxDbiO02811
PRIDEiO02811

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282309
KEGGibta:282309

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5297

Phylogenomic databases

eggNOGiKOG0902 Eukaryota
COG5032 LUCA
HOGENOMiHOG000007272
InParanoidiO02811
KOiK00888
OrthoDBi1147978at2759
TreeFamiTF102041

Gene expression databases

BgeeiENSBTAG00000013971 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI4KA_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O02811
Secondary accession number(s): F1MLV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 17, 2016
Last modified: June 5, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again