Apoptosis regulator BAX

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BH3 domain binding Source: UniProtKB
• channel activity Source: UniProtKB
• chaperone binding Source: Ensembl
• Hsp70 protein binding Source: Ensembl
• lipid binding Source: UniProtKB
• protein heterodimerization activity Source: GO_Central
• protein homodimerization activity Source: HGNC

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
• activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
• activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
• apoptotic mitochondrial changes Source: UniProtKB
• apoptotic process involved in blood vessel morphogenesis Source: Ensembl
• apoptotic process involved in embryonic digit morphogenesis Source: Ensembl
• apoptotic signaling pathway Source: UniProtKB
• B cell apoptotic process Source: UniProtKB
• B cell homeostasis Source: Ensembl
• B cell homeostatic proliferation Source: Ensembl
• B cell negative selection Source: Ensembl
• B cell receptor apoptotic signaling pathway Source: Ensembl
• blood vessel remodeling Source: Ensembl
• cellular response to organic substance Source: Ensembl
• cellular response to UV Source: Ensembl
• cerebral cortex development Source: Ensembl
• development of secondary sexual characteristics Source: Ensembl
• ectopic germ cell programmed cell death Source: Ensembl
• establishment or maintenance of transmembrane electrochemical gradient Source: UniProtKB
• extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
• extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
• fertilization Source: Ensembl
• germ cell development Source: Ensembl
• glycosphingolipid metabolic process Source: Ensembl
• homeostasis of number of cells within a tissue Source: Ensembl
• hypothalamus development Source: Ensembl
• intrinsic apoptotic signaling pathway Source: UniProtKB
• intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
• intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
• kidney development Source: Ensembl
• mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
• mitochondrial fusion Source: UniProtKB
• mitochondrion morphogenesis Source: Ensembl
• myeloid cell homeostasis Source: Ensembl
• negative regulation of apoptotic signaling pathway Source: Ensembl
• negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
• negative regulation of fibroblast proliferation Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of peptidyl-serine phosphorylation Source: Ensembl
• negative regulation of protein binding Source: UniProtKB
• neuron apoptotic process Source: Ensembl
• neuron migration Source: Ensembl
• odontogenesis of dentin-containing tooth Source: Ensembl
• ovarian follicle development Source: Ensembl
• positive regulation of apoptotic DNA fragmentation Source: Ensembl
• positive regulation of apoptotic process Source: UniProtKB
• positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
• positive regulation of B cell apoptotic process Source: Ensembl
• positive regulation of developmental pigmentation Source: Ensembl
• positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
• positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
• positive regulation of neuron apoptotic process Source: UniProtKB
• positive regulation of protein oligomerization Source: UniProtKB
• positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
• positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
• post-embryonic camera-type eye morphogenesis Source: Ensembl
• protein homooligomerization Source: HGNC
• protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
• regulation of cell cycle Source: Ensembl
• regulation of mammary gland epithelial cell proliferation Source: Ensembl
• regulation of mitochondrial membrane permeability involved in programmed necrotic cell death Source: Ensembl
• regulation of mitochondrial membrane potential Source: UniProtKB
• regulation of nitrogen utilization Source: Ensembl
• regulation of protein heterodimerization activity Source: Ensembl
• regulation of protein homodimerization activity Source: UniProtKB
• release of cytochrome c from mitochondria Source: UniProtKB
• release of matrix enzymes from mitochondria Source: UniProtKB
• response to axon injury Source: Ensembl
• response to gamma radiation Source: Ensembl
• response to salt stress Source: Ensembl
• response to toxic substance Source: UniProtKB
• retina development in camera-type eye Source: Ensembl
• retinal cell programmed cell death Source: Ensembl
• Sertoli cell proliferation Source: Ensembl
• spermatid differentiation Source: Ensembl
• T cell homeostatic proliferation Source: Ensembl
• thymocyte apoptotic process Source: Ensembl
• vagina development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• BH3 domain binding Source: UniProtKB
• chaperone binding Source: Ensembl
• Hsp70 protein binding Source: Ensembl
• protein heterodimerization activity Source: GO_Central
• protein homodimerization activity Source: HGNC

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG ETPELGLEQV 
        60         70         80         90        100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAAEMF 
       110        120        130        140        150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 
       160        170        180        190 
WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG         

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ