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Protein

Heat shock protein 60A

Gene

Hsp60A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MoonProtiO02649

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60AImported
Gene namesi
Name:Hsp60AImported
Synonyms:hsp601 Publication
ORF Names:CG12101Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015245 Hsp60A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 57Mitochondrion1 PublicationAdd BLAST57
ChainiPRO_000000503158 – 573Heat shock protein 60AAdd BLAST516

Proteomic databases

PaxDbiO02649
PRIDEiO02649

Expressioni

Gene expression databases

BgeeiFBgn0015245 Expressed in 45 organ(s), highest expression level in embryo
ExpressionAtlasiO02649 baseline and differential
GenevisibleiO02649 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi58460, 60 interactors
DIPiDIP-20404N
STRINGi7227.FBpp0073290

Structurei

3D structure databases

ProteinModelPortaliO02649
SMRiO02649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000005727
InParanoidiO02649
KOiK04077
OMAiTDTDKME
OrthoDBiEOG091G04JM
PhylomeDBiO02649

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O02649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRLPVSLAR SSISRQLAMR GYAKDVRFGP EVRAMMLQGV DVLADAVAVT
60 70 80 90 100
MGPKGRNVII EQSWGSPKIT KDGVTVAKSI ELKDKFQNIG AKLVQDVANN
110 120 130 140 150
TNEEAGDGTT TATVLARAIA KEGFEKISKG ANPVEIRRGV MLAVETVKDN
160 170 180 190 200
LKTMSRPVST PEEIAQVATI SANGDQAIGN LISEAMKKVG RDGVITVKDG
210 220 230 240 250
KTLTDELEVI EGMKFDRGYI SPYFINSSKG AKVEFQDALL LLSEKKISSV
260 270 280 290 300
QSIIPALELA NAQRKPLVII AEDIDGEALS TLVVNRLKIG LQVAAVKAPG
310 320 330 340 350
FGDNRKSTLT DMAIASGGIV FGDDADLVKL EDVKVSDLGQ VGEVVITKDD
360 370 380 390 400
TLLLKGKGKK DDVLRRANQI KDQIEDTTSE YEKEKLQERL ARLASGVALL
410 420 430 440 450
RVGGSSEVEV NEKKDRVHDA LNATRAAVEE GIVPGGGTAL LRCIEKLEGV
460 470 480 490 500
ETTNEDQKLG VEIVRRALRM PCMTIAKNAG VDGAMVVAKV ENQAGDYGYD
510 520 530 540 550
ALKGEYGNLI EKGIIDPTKV VRTAITDASG VASLLTTAEA VVTEIPKEDG
560 570
APAMPGMGGM GGMGGMGGMG GMM
Length:573
Mass (Da):60,809
Last modified:December 1, 2000 - v3
Checksum:i7A3792C1D2F3BE4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261 – 262NA → KS in CAA67720 (Ref. 1) Curated2
Sequence conflicti318 – 321GIVF → ARVG in CAA70287 (PubMed:10071211).Curated4
Sequence conflicti371 – 373KDQ → RTK in CAA67720 (Ref. 1) Curated3
Sequence conflicti414K → E in CAA67720 (Ref. 1) Curated1
Sequence conflicti439 – 443ALLRC → RLVRL in CAA67720 (Ref. 1) Curated5
Sequence conflicti468L → S in CAA67720 (Ref. 1) Curated1
Sequence conflicti492N → T in AAQ23524 (Ref. 4) Curated1
Sequence conflicti492N → T in CAA70287 (PubMed:10071211).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99341 mRNA Translation: CAA67720.1
AE014298 Genomic DNA Translation: AAF47998.1
AE014298 Genomic DNA Translation: AAF47999.1
BT010206 mRNA Translation: AAQ23524.1
Y09066 mRNA Translation: CAA70287.1
RefSeqiNP_511115.2, NM_078560.3
NP_727489.1, NM_167266.1
UniGeneiDm.313

Genome annotation databases

EnsemblMetazoaiFBtr0073434; FBpp0073290; FBgn0015245
FBtr0073435; FBpp0073291; FBgn0015245
GeneIDi32045
KEGGidme:Dmel_CG12101

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99341 mRNA Translation: CAA67720.1
AE014298 Genomic DNA Translation: AAF47998.1
AE014298 Genomic DNA Translation: AAF47999.1
BT010206 mRNA Translation: AAQ23524.1
Y09066 mRNA Translation: CAA70287.1
RefSeqiNP_511115.2, NM_078560.3
NP_727489.1, NM_167266.1
UniGeneiDm.313

3D structure databases

ProteinModelPortaliO02649
SMRiO02649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58460, 60 interactors
DIPiDIP-20404N
STRINGi7227.FBpp0073290

Protein family/group databases

MoonProtiO02649

Proteomic databases

PaxDbiO02649
PRIDEiO02649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073434; FBpp0073290; FBgn0015245
FBtr0073435; FBpp0073291; FBgn0015245
GeneIDi32045
KEGGidme:Dmel_CG12101

Organism-specific databases

CTDi32045
FlyBaseiFBgn0015245 Hsp60A

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000005727
InParanoidiO02649
KOiK04077
OMAiTDTDKME
OrthoDBiEOG091G04JM
PhylomeDBiO02649

Miscellaneous databases

ChiTaRSiHsp60 fly
GenomeRNAii32045
PROiPR:O02649

Gene expression databases

BgeeiFBgn0015245 Expressed in 45 organ(s), highest expression level in embryo
ExpressionAtlasiO02649 baseline and differential
GenevisibleiO02649 DM

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCH60A_DROME
AccessioniPrimary (citable) accession number: O02649
Secondary accession number(s): A4V4A0
, P35380, Q6NR71, Q95026, Q9VZ31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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