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Protein

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Gene

sucl-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.UniRule annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (suca-1), Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (sucl-1), Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (sucl-2), Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (sucg-1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69Coenzyme AUniRule annotation1
Binding sitei186Substrate; shared with subunit betaUniRule annotation1
Active sitei278Tele-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processTricarboxylic acid cycleUniRule annotation
LigandNucleotide-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223; UER00999

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialUniRule annotation (EC:6.2.1.4UniRule annotation, EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit alphaUniRule annotation
Short name:
SCS-alphaUniRule annotation
Gene namesi
Name:sucl-2Imported
ORF Names:CELE_F23H11.3Imported, F23H11.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF23H11.3 ; CE09611 ; WBGene00017759 ; sucl-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

EPDiO02642
PaxDbiO02642
PeptideAtlasiO02642

Expressioni

Gene expression databases

BgeeiWBGene00017759

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).UniRule annotation

Protein-protein interaction databases

DIPiDIP-25090N
STRINGi6239.F23H11.3.1

Structurei

3D structure databases

ProteinModelPortaliO02642
SMRiO02642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 126CoA_bindingInterPro annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 46Coenzyme A bindingUniRule annotation4
Regioni122 – 124Coenzyme A bindingUniRule annotation3

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1255 Eukaryota
COG0074 LUCA
GeneTreeiENSGT00530000063275
HOGENOMiHOG000239685
InParanoidiO02642
KOiK01899
OMAiIIFVPPA
OrthoDBiEOG091G0D9C
PhylomeDBiO02642

Family and domain databases

Gene3Di3.40.50.261, 1 hit
HAMAPiMF_01988 Succ_CoA_alpha, 1 hit
InterProiView protein in InterPro
IPR017440 Cit_synth/succinyl-CoA_lig_AS
IPR033847 Citrt_syn/SCS-alpha_CS
IPR003781 CoA-bd
IPR005810 CoA_lig_alpha
IPR005811 CoA_ligase
IPR036291 NAD(P)-bd_dom_sf
IPR016102 Succinyl-CoA_synth-like
PfamiView protein in Pfam
PF02629 CoA_binding, 1 hit
PF00549 Ligase_CoA, 1 hit
PIRSFiPIRSF001553 SucCS_alpha, 1 hit
SMARTiView protein in SMART
SM00881 CoA_binding, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52210 SSF52210, 1 hit
TIGRFAMsiTIGR01019 sucCoAalpha, 1 hit
PROSITEiView protein in PROSITE
PS01216 SUCCINYL_COA_LIG_1, 1 hit
PS00399 SUCCINYL_COA_LIG_2, 1 hit

Sequencei

Sequence statusi: Complete.

O02642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTLASAAR AATRAAVTRS VYNDTRNNLM INKSTKVIVQ GFTGRQGTFH
60 70 80 90 100
SKQMLEYNTN LVGGVSPNKA GQTHLGLPVF GSVAEAKDRT GADATVIYVP
110 120 130 140 150
AAGAARAIHE AMDAEIGLIV AITEGIPQQD MVRVKNRLLK QNKSRLLGPN
160 170 180 190 200
CPGIIASGDC KIGIMPGHIH KKGCIGIVSR SGTLTYEAVH QTTTVGLGQT
210 220 230 240 250
RCIGIGGDPF NGTNFIDCLE VFLEDEQTKG IILIGEIGGQ AEEQAAEFLK
260 270 280 290 300
SRNSGSNAKP VVSFIAGVTA PPGRRMGHAG AIIAGGKGTA GDKIEALRNA
310 320
NVVVTDSPAK LGVAMQKALL G
Length:321
Mass (Da):33,366
Last modified:July 1, 1997 - v1
Checksum:iFBE0AEEA412EF4F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD69944.1
PIRiT34065
RefSeqiNP_497288.1, NM_064887.5
UniGeneiCel.37553

Genome annotation databases

EnsemblMetazoaiF23H11.3.1; F23H11.3.1; WBGene00017759
F23H11.3.2; F23H11.3.2; WBGene00017759
GeneIDi175252
KEGGicel:CELE_F23H11.3
UCSCiF23H11.3.1 c. elegans

Entry informationi

Entry nameiO02642_CAEEL
AccessioniPrimary (citable) accession number: O02642
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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