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UniProtKB - O02639 (RL19_CAEEL)

Entry version 138 (25 May 2022)
Sequence version 1 (01 Jul 1997)
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Protein

60S ribosomal protein L19

Gene

rpl-19

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • translation Source: InterPro
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339, SRP-dependent cotranslational protein targeting to membrane
R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-CEL-72689, Formation of a pool of free 40S subunits
R-CEL-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O02639

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpl-19
ORF Names:C09D4.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...WormBasei		C09D4.5 ; CE08034 ; WBGene00004431 ; rpl-19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001311761 – 19860S ribosomal protein L19Add BLAST198

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O02639

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O02639

PeptideAtlas

More...PeptideAtlasi		O02639

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O02639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00004431, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		37659, 99 interactors

Database of interacting proteins

More...DIPi		DIP-25603N

Protein interaction database and analysis system

More...IntActi		O02639, 3 interactors

STRING: functional protein association networks

More...STRINGi		6239.C09D4.5.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O02639

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O02639

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 85DisorderedSequence analysisAdd BLAST20
Regioni150 – 177DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eL19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1696, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_083919_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O02639

Identification of Orthologs from Complete Genome Data

More...OMAi		NRVWIDP

Database of Orthologous Groups

More...OrthoDBi		1437042at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O02639

Family and domain databases

Conserved Domains Database

More...CDDi		cd01417, Ribosomal_L19e_E, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1650.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01475, Ribosomal_L19e, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035970, 60S_ribosomal_L19/L19e_sf
IPR000196, Ribosomal_L19/L19e
IPR023638, Ribosomal_L19/L19e_CS
IPR015972, Ribosomal_L19/L19e_dom1
IPR033935, Ribosomal_L19_euka
IPR039547, RPL19

The PANTHER Classification System

More...PANTHERi		PTHR10722, PTHR10722, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01280, Ribosomal_L19e, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01416, Ribosomal_L19e, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48140, SSF48140, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00526, RIBOSOMAL_L19E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O02639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNLRLQKRL ASAVLKCGKH RVWLDPNEVS EISGANSRQS IRRLVNDGLI 
        60         70         80         90        100
IRKPVTVHSR FRAREYEEAR RKGRHTGYGK RRGTANARMP EKTLWIRRMR 
       110        120        130        140        150
VLRNLLRRYR DAKKLDKHLY HELYLRAKGN NFKNKKNLIE YIFKKKTENK 
       160        170        180        190 
RAKQLADQAQ ARRDKNKESR KRREERQVVK RAELLRKISQ SEKVIAGK
Length:198
Mass (Da):23,652
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03876B70136D0479
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FO080461 Genomic DNA Translation: CCD63892.1

Protein sequence database of the Protein Information Resource

More...PIRi		T29135

NCBI Reference Sequences

More...RefSeqi		NP_491608.1, NM_059207.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		C09D4.5.1; C09D4.5.1; WBGene00004431
C09D4.5.2; C09D4.5.2; WBGene00004431
C09D4.5.3; C09D4.5.3; WBGene00004431
C09D4.5.4; C09D4.5.4; WBGene00004431

Database of genes from NCBI RefSeq genomes

More...GeneIDi		172201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_C09D4.5

UCSC genome browser

More...UCSCi		C09D4.5.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080461 Genomic DNA Translation: CCD63892.1
PIRiT29135
RefSeqiNP_491608.1, NM_059207.5

3D structure databases

AlphaFoldDBiO02639
SMRiO02639
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi37659, 99 interactors
DIPiDIP-25603N
IntActiO02639, 3 interactors
STRINGi6239.C09D4.5.1

PTM databases

iPTMnetiO02639

Proteomic databases

EPDiO02639
PaxDbiO02639
PeptideAtlasiO02639

Genome annotation databases

EnsemblMetazoaiC09D4.5.1; C09D4.5.1; WBGene00004431
C09D4.5.2; C09D4.5.2; WBGene00004431
C09D4.5.3; C09D4.5.3; WBGene00004431
C09D4.5.4; C09D4.5.4; WBGene00004431
GeneIDi172201
KEGGicel:CELE_C09D4.5
UCSCiC09D4.5.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		172201
WormBaseiC09D4.5 ; CE08034 ; WBGene00004431 ; rpl-19

Phylogenomic databases

eggNOGiKOG1696, Eukaryota
GeneTreeiENSGT00390000012628
HOGENOMiCLU_083919_0_1_1
InParanoidiO02639
OMAiNRVWIDP
OrthoDBi1437042at2759
PhylomeDBiO02639

Enzyme and pathway databases

ReactomeiR-CEL-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-1799339, SRP-dependent cotranslational protein targeting to membrane
R-CEL-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-CEL-72689, Formation of a pool of free 40S subunits
R-CEL-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-CEL-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-CEL-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiO02639

Miscellaneous databases

Protein Ontology

More...PROi		PR:O02639

Gene expression databases

BgeeiWBGene00004431, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

CDDicd01417, Ribosomal_L19e_E, 1 hit
Gene3Di1.10.1650.10, 1 hit
HAMAPiMF_01475, Ribosomal_L19e, 1 hit
InterProiView protein in InterPro
IPR035970, 60S_ribosomal_L19/L19e_sf
IPR000196, Ribosomal_L19/L19e
IPR023638, Ribosomal_L19/L19e_CS
IPR015972, Ribosomal_L19/L19e_dom1
IPR033935, Ribosomal_L19_euka
IPR039547, RPL19
PANTHERiPTHR10722, PTHR10722, 1 hit
PfamiView protein in Pfam
PF01280, Ribosomal_L19e, 1 hit
SMARTiView protein in SMART
SM01416, Ribosomal_L19e, 1 hit
SUPFAMiSSF48140, SSF48140, 1 hit
PROSITEiView protein in PROSITE
PS00526, RIBOSOMAL_L19E, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL19_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O02639
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 25, 2022
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families
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