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UniProtKB - O02626 (MADD_CAEEL)

Entry version 146 (23 Feb 2022)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
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Protein

MAP kinase-activating death domain protein

Gene

aex-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity).

Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release (PubMed:9136770, PubMed:10970871).

Is also a regulator of the cab-1 synaptic transmission pathway (PubMed:10970871).

Probably by converting rab-3 to its GTP-bound active form, plays a role in the recruitment of endophilin unc-57 to synaptic vesicles (PubMed:21029864).

Probably by activating rab-3 and thus regulating the trafficking of dense-core vesicles, plays a role in AVG neuron-mediated formation of the right axon tract of the ventral nerve cord (PubMed:27116976).

Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:18852466).

Probably by regulating DMP, required for fatty acid uptake by intestinal cells (PubMed:25849533).

By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAP kinase-activating death domain protein
Alternative name(s):
Aboc, expulsion defective protein 3
Regulator of presynaptic activity aex-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aex-3
ORF Names:C02H7.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...WormBasei		C02H7.3a ; CE16806 ; WBGene00000086 ; aex-3
C02H7.3b ; CE30850 ; WBGene00000086 ; aex-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit pleiotropic behavioral defects that are suggestive of reduced synaptic transmission (PubMed:9136770). RNAi-mediated knockdown in the intestine causes a mild defect in the expulsion step of the defecation cycle (PubMed:18852466).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000644691 – 1409MAP kinase-activating death domain proteinAdd BLAST1409

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O02626

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O02626

PeptideAtlas

More...PeptideAtlasi		O02626

PRoteomics IDEntifications database

More...PRIDEi		O02626

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in nearly all neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00000086, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cab-1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		45373, 1 interactor

STRING: functional protein association networks

More...STRINGi		6239.C02H7.3a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 230uDENNPROSITE-ProRule annotationAdd BLAST205
Domaini251 – 390cDENNPROSITE-ProRule annotationAdd BLAST140
Domaini392 – 496dDENNPROSITE-ProRule annotationAdd BLAST105
Domaini1109 – 1184DeathAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni654 – 701DisorderedSequence analysisAdd BLAST48
Regioni761 – 784DisorderedSequence analysisAdd BLAST24
Regioni902 – 1008DisorderedSequence analysisAdd BLAST107
Regioni1015 – 1034DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi654 – 692Polar residuesSequence analysisAdd BLAST39
Compositional biasi902 – 916Polar residuesSequence analysisAdd BLAST15
Compositional biasi936 – 959Polar residuesSequence analysisAdd BLAST24
Compositional biasi962 – 1005Pro residuesSequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MADD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3570, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156718

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001270_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O02626

Identification of Orthologs from Complete Genome Data

More...OMAi		ETFSMSK

Database of Orthologous Groups

More...OrthoDBi		162625at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O02626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR039980, MADD
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

The PANTHER Classification System

More...PANTHERi		PTHR13008, PTHR13008, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211, DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: O02626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNDKEKEICP RLIDFLVVVG KRNRTRGASQ SSPDATTDTT VTYPEILRRY 
        60         70         80         90        100
PTDDHKDFIL PTDVTVFCQP EGCTTTSARL RKNARNDPQF FVFMLTEKDS 
       110        120        130        140        150
AKVRYGICLN FYQSFDRRST PKDEIKKVPD DAHHKKRDSH VSLTSLCFIS 
       160        170        180        190        200
HHPFVSIFHQ VLLLLKRIID SSNHRAAQRT GLKDVVWAIL TGHYNEPIVP 
       210        220        230        240        250
EVMKEIKEIE TWILMLLSSP VPVPGKTKVQ IEVMPMDLSQ VFEFALPDHT 
       260        270        280        290        300
RFTLIDFPLH IPFEILGIDM ALRVLTAAML EFKIVIQSRN YNAVSMCILS 
       310        320        330        340        350
IVALLYPLEY MFPVIPLLPA YMPSAEQLLL APTPFLIGVP SSFFHHRKIR 
       360        370        380        390        400
ELPSDVILVD LDTNCLQVPD DLYIPDLPEP DATHLKERLK NAINKMTTMT 
       410        420        430        440        450
VDNETSVTDA DFGIDIDSVD VACRVAMVQF FNSANVFGNF SEHTRTLRLY 
       460        470        480        490        500
PRPVVSLQTD SFLRSRPQCT QLITDLCRTQ AVEYFAECCL CPKNETFVRV 
       510        520        530        540        550
QAGIESAEQV GDKPKWFSES LMPVHFMVYP NNSTLDSAIR VYNAEIDNDD 
       560        570        580        590        600
YEDDSATSTE NSNSIDDLVF DENQVTDAGG EVTKPLAEVN YIYKEPMTLE 
       610        620        630        640        650
LPQSESVVSI DSSLSSGRSS PDSSLSTSAV DSEADFARLA DNLALKSNSQ 
       660        670        680        690        700
GAFSFDHGSD SEYESTPVSQ RRKTIHNPGS DASDTPTSRG SIKSGLRMKG 
       710        720        730        740        750
LTTLTDSGEK VLGPSLMNAI NGYAEKSQSV FSQVINKTAP KAQALKERTM 
       760        770        780        790        800
KPLANRIEQS QHIVRSKTQP NPTSQQTANQ QSKNQQTVKE FCDQALVGQS 
       810        820        830        840        850
VGMFSAPKLK RLMEDESLRE LVCSKLNLGL EVKLSEDEYV KEVQLTKGQF 
       860        870        880        890        900
KAYVKILKAC LEGIEVSFNT PGCCGFASVF HVLEIAHTHY WAMGGGEVIT 
       910        920        930        940        950
PSSSAPSTMT TPSEHSNDIL KESRPKLPAS TIDLRTPTKP LGQNVTPTST 
       960        970        980        990       1000
NNHEIAQSTR SPALPPPVPP REAPPIPKRN PPPLGAPPKV PEGARAPPPL 
      1010       1020       1030       1040       1050
PPRPKVKTTA VDETPQNLVP NNQPAQPSSP SFLADADEQT KPLLKPAPPT 
      1060       1070       1080       1090       1100
TLPVGKQEPC KVLPTPNEPV RHYIYQELIL AVQHQIWQNL QFWENAFVDL 
      1110       1120       1130       1140       1150
VAQEREIVGM DQEPSEMIDR YSALNDSEKK RLELEEDRLL STLLHNMTAY 
      1160       1170       1180       1190       1200
MIMCGTGQKA LQQKVRRLLG KAHIGLVCSK EINKLLDELP STQGNFIPLK 
      1210       1220       1230       1240       1250
PLGSRLVQKQ SFTVCPGQSS DGQMMFMEVC DDAVVLRSIT GAATERWWYE 
      1260       1270       1280       1290       1300
RLVNITYSPK TKILCLWRRH DDKVHMHKFH TKKCRELYQC MKAAMERAAA 
      1310       1320       1330       1340       1350
RGKVNVEGRA LGGEFPVHDT ETNQGGLLQV RCDGVAVIFA HNQIFIGLSN 
      1360       1370       1380       1390       1400
IKKCNTFGGN VFLLEEFDRK KGEIIQRRYF SQMADQICYA VLCVFSLAAA 

GHKKEEHSK
Length:1,409
Mass (Da):157,459
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DDE6395AC963313
GO
Isoform b (identifier: O02626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1409: DQICYAVLCVFSLAAAGHKKEEHSK → VDIAWAMHRVFSVQFAISCQKDTN

Show »
Length:1,408
Mass (Da):157,478
Checksum:i16BBDA4252C87C29
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0155551385 – 1409DQICY…EEHSK → VDIAWAMHRVFSVQFAISCQ KDTN in isoform b. CuratedAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U93842 mRNA Translation: AAB52421.1
FO080298 Genomic DNA Translation: CCD62710.1
FO080298 Genomic DNA Translation: CCD62711.1

Protein sequence database of the Protein Information Resource

More...PIRi		T37188

NCBI Reference Sequences

More...RefSeqi		NP_001024342.1, NM_001029171.3 [O02626-2]
NP_741710.1, NM_171618.3 [O02626-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		C02H7.3a.1; C02H7.3a.1; WBGene00000086 [O02626-1]
C02H7.3b.1; C02H7.3b.1; WBGene00000086 [O02626-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		180420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_C02H7.3

UCSC genome browser

More...UCSCi		C02H7.3a, c. elegans [O02626-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93842 mRNA Translation: AAB52421.1
FO080298 Genomic DNA Translation: CCD62710.1
FO080298 Genomic DNA Translation: CCD62711.1
PIRiT37188
RefSeqiNP_001024342.1, NM_001029171.3 [O02626-2]
NP_741710.1, NM_171618.3 [O02626-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi45373, 1 interactor
STRINGi6239.C02H7.3a

Proteomic databases

EPDiO02626
PaxDbiO02626
PeptideAtlasiO02626
PRIDEiO02626

Genome annotation databases

EnsemblMetazoaiC02H7.3a.1; C02H7.3a.1; WBGene00000086 [O02626-1]
C02H7.3b.1; C02H7.3b.1; WBGene00000086 [O02626-2]
GeneIDi180420
KEGGicel:CELE_C02H7.3
UCSCiC02H7.3a, c. elegans [O02626-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		180420
WormBaseiC02H7.3a ; CE16806 ; WBGene00000086 ; aex-3
C02H7.3b ; CE30850 ; WBGene00000086 ; aex-3

Phylogenomic databases

eggNOGiKOG3570, Eukaryota
GeneTreeiENSGT00940000156718
HOGENOMiCLU_001270_0_0_1
InParanoidiO02626
OMAiETFSMSK
OrthoDBi162625at2759
PhylomeDBiO02626

Enzyme and pathway databases

ReactomeiR-CEL-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Protein Ontology

More...PROi		PR:O02626

Gene expression databases

BgeeiWBGene00000086, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

Gene3Di3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR039980, MADD
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PANTHERiPTHR13008, PTHR13008, 1 hit
PfamiView protein in Pfam
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMADD_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O02626
Secondary accession number(s): Q27467, Q8MQF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: February 23, 2022
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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