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Protein

Heat shock protein 83

Gene

Hsp83

Organism
Drosophila auraria (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATPBy similarity1
Binding sitei81ATPBy similarity1
Binding sitei100ATPBy similarity1
Binding sitei126ATP; via amide nitrogenBy similarity1
Binding sitei384ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 83
Alternative name(s):
HSP 82
Gene namesi
Name:Hsp83
Synonyms:Hsp82
OrganismiDrosophila auraria (Fruit fly)
Taxonomic identifieri47315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020208 Daur\Hsp83

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629291 – 716Heat shock protein 83Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO02192

Interactioni

Subunit structurei

Homodimer. Interacts with shu (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO02192
SMRiO02192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi712 – 716TPR repeat-binding5

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

O02192-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEEAETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNA SDALDKIRYE
60 70 80 90 100
SLTDPSKLDS GKELYIKLIP NKTAGTLTII DTGIGMTKSD LVNNLGTIAK
110 120 130 140 150
SGTKAFMEAL QAGADISMIG QFGVGFYSAY LVADKVTVTS KNNDDEQYIW
160 170 180 190 200
ESSAGGSFTV RADNSEPLGR GTKIVLYIKE DQTDYLEESK IKEIVNKHSQ
210 220 230 240 250
FIGYPIKLLV EKEREKEVSD DEADDDKKED EKKEMDTDEP KIEDVGEDED
260 270 280 290 300
ADKKDKDAKK KKTIKEKYTE DEELNKTKPI WTRNPDDISQ EEYGEFYKSL
310 320 330 340 350
TNDWEDHLAV KHFSVEGQLE FRALLFIPRR TPFDLFENQK KRNNIKLYVR
360 370 380 390 400
RVFIMDNCED LIPEYLNFIK GVVDSEDLPL NISREMLQQN KVLKVIRKNL
410 420 430 440 450
VKKTMELIEE LTEDKENYKK FYDQFSKNLK LGVHEDSNNR AKLADFLRFH
460 470 480 490 500
TSASGDDFCS LSDYVSRMKE NQKHVYFITG ESKDQVSNSA FVERVKARGF
510 520 530 540 550
EVVYMTEPID EYVIQHLKEY KGKQLVSVTK EGLELPEDDA EKKKREEDKA
560 570 580 590 600
KFESLCKLMN AILDNKVEKV VVSNRLVDSP CCIVTSQFGW SANMERIMKA
610 620 630 640 650
QALRDTATMG YMAGKKQLEI NPDHPIVETL RQKADADKND KAVKDLVILL
660 670 680 690 700
FETSLLSSGF SLDSPQVHAS RIYRMIKLGL GIDEDEPMTT EDAQSAGDAP
710
SLVEDTEDAS HMEEVD
Length:716
Mass (Da):81,760
Last modified:July 1, 1997 - v1
Checksum:i9EC59F027C4DFCD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75687 Genomic DNA Translation: AAB58358.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75687 Genomic DNA Translation: AAB58358.1

3D structure databases

ProteinModelPortaliO02192
SMRiO02192
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO02192

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0020208 Daur\Hsp83

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP83_DROAV
AccessioniPrimary (citable) accession number: O02192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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