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Protein

Nuclear hormone receptor family member nhr-14

Gene

nhr-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 92Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri20 – 40NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri56 – 80NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO02151

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-14
Gene namesi
Name:nhr-14
ORF Names:T01B10.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01B10.4a ; CE33818 ; WBGene00003613 ; nhr-14
T01B10.4b ; CE33819 ; WBGene00003613 ; nhr-14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537671 – 435Nuclear hormone receptor family member nhr-14Add BLAST435

Proteomic databases

PaxDbiO02151
PRIDEiO02151

Expressioni

Gene expression databases

BgeeiWBGene00003613 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

BioGridi46023, 1 interactor
STRINGi6239.T01B10.4a.2

Structurei

3D structure databases

ProteinModelPortaliO02151
SMRiO02151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 355NR LBDPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 40NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri56 – 80NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215 Eukaryota
ENOG410XQT8 LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000022323
InParanoidiO02151
OMAiNIDKDHR
OrthoDBiEOG091G0A89
PhylomeDBiO02151

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: O02151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFLISTSLS ESTSTSADFC VVCGDKAIGK HYGAVACNGC KGFFRRSVWQ
60 70 80 90 100
NLQYTCRFNK QCNIDKDHRN ACRYCRFQKC LADGMKPEAI QNERDRIGST
110 120 130 140 150
KRRKRSGANS ENNSDSEGTP SPKIEVMGNS VSRKLIEMLL DIEHRLASNQ
160 170 180 190 200
SMNALLRDES EMKNSRQRAV NYLIGWTNML HPLPEVPLAD KVLLLKKFSS
210 220 230 240 250
AFTLLGTLQR SMALPHFVLP NDQVLSISAS HPPELFEALT RIIDELLTPL
260 270 280 290 300
RRLRTDHAEF SCLKALLLLN PDVVGISNNT RERIREARDA LLKTLFAYMS
310 320 330 340 350
NTQNSIDASL RVSSLLMIIP SLISVSSSIM EFPALSDLFG LGDVIKRDTI
360 370 380 390 400
SPKIETPPLE MKPMMPKIAQ PPVTSAPTVP TNIMMNKDLI SQIMNNPQLF
410 420 430
PLLPMPQTAS PPMSFMGQSE FGCHLQSMPV KVILS
Length:435
Mass (Da):48,560
Last modified:March 1, 2004 - v3
Checksum:iF0F6E770ED804536
GO
Isoform b (identifier: O02151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-435: EFGCHLQSMPVKVILS → YNRNSDVIFSQCPSK

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):48,530
Checksum:iD633A0F96D5CDACC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007344420 – 435EFGCH…KVILS → YNRNSDVIFSQCPSK in isoform b. CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081164 Genomic DNA Translation: CCD69597.1
FO081164 Genomic DNA Translation: CCD69598.1
AF083229 mRNA Translation: AAD03687.1
PIRiT43353
RefSeqiNP_741860.2, NM_171742.3 [O02151-1]
NP_741861.2, NM_171743.3 [O02151-2]
UniGeneiCel.630

Genome annotation databases

EnsemblMetazoaiT01B10.4a.1; T01B10.4a.1; WBGene00003613 [O02151-1]
T01B10.4a.2; T01B10.4a.2; WBGene00003613 [O02151-1]
GeneIDi181102
KEGGicel:CELE_T01B10.4
UCSCiT01B10.4b c. elegans [O02151-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNHR14_CAEEL
AccessioniPrimary (citable) accession number: O02151
Secondary accession number(s): Q8MPT6, Q9UAN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 1, 2004
Last modified: September 12, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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